Processes for detecting toxic substances

ABSTRACT

Biology-based processes for detecting toxic substances are provided. The processes comprise detecting mRNA that is expressed in the presence of toxic substances by a cell comprising a yeast gene as followed, or a gene that is homologous to the yeast genes and is derived from other species, wherein the mRNA corresponds to said yeast gene or said homologous gene thereof

FILED OF THE INVENTION

This invention relates to biology-based processes for detecting toxic substances, and specifically to processes for detecting toxic substances which comprises detecting mRNA that is transcribed in the presence of test materials by a particular gene from yeast.

BACKGROUND ART

Environmental chemical fate search has been conducted every year for 24 years from 1974 through 1998 by Environment Agency, and revealed that about 40% of 775 chemical substances that have been searched so far are emitted into the environment. Chemical substances that are industrially produced at the present in Japan are estimated about 50,000, and the production scale and the kinds of chemical substances are increasing year by year. It is known that chemical substances that are accidentally produced by water treatment with chlorine and incineration pollute the environment. Although such facts allow us to predict that there are a large number of chemical substances that have been accumulated in the environment, it is extremely difficult to search and examine individually the all chemical substances.

Conventional bioassays (approaches to evaluate the harmful effects on biological materials on the basis of their responses) wherein inhibited growth and particular biological responses in individuals and cells of fishes, daphnia and shellfish are used as indicators make it possible to determine the presence or absence of the toxicity of chemical substances in the environment, but neither possible to evaluate the characters nor origins of the toxicity. The evaluation methods based on the activity of nitrite-forming bacteria or nitrate-forming bacteria (Japanese Patent Publication (kokai) No. 123705/1994, Japanese Patent Publication (kokai) No. 2000-206087) and the activity of iron bacteria have been proposed, and devices such as Acute toxiciants monitor (Fuji Electric Corporate Research and Development, Ltd. Japan) are marketed in Japan. In foreign countries, the devices for evaluation based on emission intensity of luminous bacteria are commercially available (MICROTOX, azur, Co., USA; LUMIS, drlange, Co. Germany). However, those devices still involve conventional bioassays, and never provide any detailed information of toxic chemical substances.

In Japan, the risk control of chemical substances is reconsidered every time a chemical substance pollution is newly found, and official regulations and self-imposed regulations are combined to organize the system for risk control. However, any system has not been yet organized that could quickly respond to the present complicated and diversified conditions including accidental productions and environmental emission of toxic chemical substance as typified by trihalomethane and dioxin. Animal experiments as used in the method for evaluation of toxic substance of “Law Concerning Examination and Manufacture, etc. of Chemical Substances” are expensive and time-consuming, and are not accepted across the world. Although, as such, the control system has been continuously discussed, it has not been successfully accomplished because there is no way to dissolve the problem. Thus, a method for detect readily chemical substances occurring in the environment is desired.

DISCLOSURE OF THE INVENTION

The inventors of the present application found that a toxic substance induces the expression of mRNA from particular yeast genes, and accomplished the present invention.

Specifically, the invention of the present application relates a process for detecting a toxic substance, which comprises detecting mRNA that is expressed in the presence of a test material by a cell comprising a yeast gene that is selected from a group consisting of the following, or a gene that is homologous to the yeast genes and is derived from other species, wherein the mRNA corresponds to said yeast gene or said homologous gene thereof: YBR072W, YCR102C, YCR107W, YDL218W, YDL243C, YDR453C, YDR533C, YFL014W, YFL056C, YFL057C, YGR110W, YJR155W, YKL071W, YKR076W, YLL060C, YLR460C, YMR090W, YNL331C, YNL332W, YNL335W, YOL150C, YOL165C, YPL171C, YPR167C, YBL048W, YBL064C, YBL107C, YBR008C, YBR173C, YBR256C, YBR296C, YDL021W, YFL022C, YFL024C, YFL061W, YGL121C, YGL158W, YGR043C, YHR029C, YHR112C, YHR139C, YHR179W, YHR209W, YIR030C, YJR010W, YJR048W, YKL001C, YKL107W, YKR075C, YKR097W, YLL056C, YLR297W, YLR303W, YML087C, YMR096W, YNL274C, YOL151W, YOR226C, YOR338W, YOR391C, YPL280W, YDR406W, YJL153C, YLR346C, YOR049C, YOR153W, YPL088W, YAL034C, YDL124W, YDL174C, YDR476C, YGL156W, YGR035C, YGR157W, YGR213C, YGR281W, YGR284C, YHL047C, YHR043C, YHR044C, YHR054C, YJR073C, YKL165C, YLR008C, YMR315W, YNL211C, YOL031C, YOL101C, YOR303W, YAL005C, YAR031W, YBL005W-A, YBL022C, YBL041W, YBL049W, YBL075C, YBL078C, YBR062C, YBR169C, YBR294W, YCL020W, YCL035C, YCL043C, YCL050C, YCL057W, YCR012W, YCR013C, YCR060W, YDL007W, YDL027C, YDL097C, YDL110C, YDL126C, YDL169C, YDR070C, YDR155C, YDR158W, YDR204W, YDR210W, YDR214W, YDR258C, YDR313C, YDR368W, YDR435C, YER012W, YER037W, YER091C, YER103W, YFL044C, YFR003C, YFR010W, YFR020W, YFR024C, YFR044C, YFR053C, YGL006W, YGL048C, YGL062W, YGL141W, YGL157W, YGL163C, YGL180W, YGL184C, YGR010W, YGR028W, YGR032W, YGR048W, YGR124W, YGR135W, YGR142W, YGR161C, YGR192C, YGR197C, YGR201C, YGR212W, YGR231C, YGR244C, YGR254W, YGR268C, YHL030W, YHR016C, YHR018C, YHR055C, YHR087W, YHR166C, YIL160C, YIR017C, YJL034W, YJL048C, YJL052W, YJL144W, YJL163C, YJR009C, YJR069C, YJR074W, YJR130C, YJR149W, YKL065C, YKL073W, YKL103C, YKL142W, YKL210W, YKL218C, YKR011C, YKR018C, YKR046C, YKR049C, YLL024C, YLL026W, YLR027C, YLR080W, YLR107W, YLR121C, YLR132C, YLR133W, YLR155C, YLR158C, YLR161W, YLR195C, YLR217W, YLR328W, YLR336C, YLR345W, YLR370C, YLR423C, YML004C, YML092C, YML128C, YML130C, YML131W, YMR040W, YMR118C, YMR214W, YMR251W, YMR297W, YMR322C, YNL036W, YNL055C, YNL071W, YNL094W, YNL134C, YNL155W, YNL160W, YNL239W, YNL241C, YOL005C, YOR020C, YOR027W, YOR037W, YOR059C, YOR120W, YOR134W, YOR152C, YOR173W, YOR289W, YOR362C, YPL240C, YPR030W, YAL008W, YAL023C, YAL060W, YAL062W, YAR009C, YBL101C, YBR006W, YBR046C, YBR052C, YBR053C, YBR056W, YBR099C, YBR137W, YBR139W, YBR149W, YBR170C, YBR177C, YBR203W, YBR207W, YBR212W, YBR239C, YBR284W, YBR293W, YCL018W, YCL033C, YCL040W, YCL049C, YCR062W, YCR067C, YCR082W, YDL010W, YDL020C, YDL024C, YDL054C, YDL095W, YDL100C, YDL115C, YDL144C, YDL198C, YDL223C, YDL245C, YDL246C, YDR001C, YDR032C, YDR058C, YDR072C, YDR127W, YDR168W, YDR169C, YDR188W, YDR231C, YDR261C, YDR264C, YDR272W, YDR293C, YDR304C, YDR330W, YDR403W, YDR411C, YDR427W, YDR436W, YDR497C, YDR511W, YDR516C, YDR519W, YDR545W, YEL012W, YEL030W, YER004W, YER009W, YER021W, YER035W, YER053C, YER079W, YER094C, YER096W, YER125W, YER158C, YER163C, YER175C, YER177W, YER178W, YER185W, YFL006W, YFL010C, YFL016C, YFL029C, YFL030W, YFL031W, YFL032W, YFL038C, YFL041W, YFR004W, YFR047C, YFR050C, YFR052W, YGL011C, YGL013C, YGL037C, YGL047W, YGL053W, YGL091C, YGL094C, YGL127C, YGL150C, YGL199C, YGL207W, YGL248W, YGR008C, YGR037C, YGR055W, YGR101W, YGR130C, YGR154C, YGR194C, YGR221C, YGR232W, YGR248W, YGR253C, YGR256W, YHL008C, YHR027C, YHR053C, YHR057C, YHR111W, YHR138C, YHR161C, YHR164C, YHR169W, YHR174W, YHR176W, YHR199C, YIL010W, YIL034C, YIL041W, YIL045W, YIL087C, YIL107C, YIL142W, YIL155C, YIR034C, YIR036C, YIR037W, YIR038C, YIR039C, YJL001W, YJL031C, YJL035C, YJL053W, YJL057C, YJL066C, YJL068C, YJL082W, YJL099W, YJL102W, YJL151C, YJL152W, YJL161W, YJL164C, YJL171C, YJL172W, YJL210W, YJL219W, YJR008W, YJR045C, YJR046W, YJR106W, YJR117W, YJR137C, YKL007W, YKL026C, YKL035W, YKL091C, YKL104C, YKL117W, YKL145W, YKL146W, YKL151C, YKL152C, YKL153W, YKL193C, YKL195W, YKL213C, YKL215C, YLL028W, YLL039C, YLL058W, YLR054C, YLR103C, YLR120C, YLR136C, YLR149C, YLR152C, YLR178C, YLR259C, YLR299W, YLR324W, YLR327C, YLR348C, YLR350W, YLR356W, YLR362W, YLR387C, YLR429W, YML054C, YML070W, YML100W, YML117W, YML125C, YMR004W, YMR008C, YMR009W, YMR020W, YMR067C, YMR089C, YMR097C, YMR102C, YMR105C, YMR107W, YMR152W, YMR180C, YMR184W, YMR191W, YMR219W, YMR271C, YMR275C, YMR295C, YMR314W, YMR316W, YNL006W, YNL007C, YNL012W, YNL044W, YNL045W, YNL074C, YNL092W, YNL093W, YNL104C, YNL115C, YNL156C, YNL231C, YNL234W, YNL237W, YNL281W, YNL305C, YNL333W, YNR010W, YNR019W, YNR033W, YNR059W, YNR068C, YNR069C, YOL032W, YOL036W, YOL047C, YOL071W, YOL082W, YOL083W, YOL117W, YOL119C, YOL126C, YOL131W, YOL153C, YOL162W, YOL163W, YOL164W, YOR019W, YOR035C, YOR036W, YOR099W, YOR117W, YOR124C, YOR130C, YOR132W, YOR157C, YOR185C, YOR197W, YOR259C, YOR261C, YOR273C, YOR288C, YOR332W, YOR336W, YOR347C, YPL017C, YPL087W, YPL106C, YPL109C, YPL149W, YPL154C, YPL196W, YPL206C, YPL222W, YPR023C, YPR024W, YPR026W, YPR067W, YPR103W, YPR108W, YPR151C, YAL012W, YBR029C, YBR222C, YCL009C, YCL027W, YCL064C, YCR098C, YDL222C, YDR055W, YDR077W, YDR502C, YEL001C, YEL042W, YER026C, YER106W, YGR136W, YGR138C, YHR137W, YHR142W, YIL023C, YIL153W, YJL073W, YJR004C, YJR054W, YKL039W, YKL086W, YKL163W, YKR091W, YLR109W, YLR194C, YLR250W, YMR095C, YMR189W, YNL106C, YNL169C, YNL322C, YOR181W, YOR198C, YOR208W, YOR247W, YPL089C, YAL038W, YAL053W, YBR023C, YBR214W, YBR295W, YCR048W, YDL072C, YDL204W, YDR085C, YDR098C, YDR259C, YDR380W, YDR388W, YDR391C, YDR432W, YDR481C, YDR510W, YER069W, YGL022W, YGL126W, YGL209W, YGL255W, YGR189C, YGR282C, YHL035C, YHR030C, YIL022W, YIL024C, YIL117C, YIL123W, YIL140W, YIL154C, YJL088W, YJL108C, YJL149W, YJL159W, YJL186W, YJR148W, YKL096W, YLR180W, YLR273C, YLR300W, YLR307W, YLR378C, YLR391W, YMR094W, YMR104C, YMR276W, YMR296C, YNL190W, YNL208W, YNL300W, YNR064C, YOL013C, YOL058W, YOR248W, YOR355W, YPL052W, YPL163C, YPR079W, YAR028W, YBR146W, YBR183W, YCL038C, YCR071C, YDL008W, YDR019C, YDR031W, YDR115W, YDR486C, YER038C, YER130C, YFL054C, YGL136C, YGR146C, YGR207C, YHL040C, YIL167W, YJL020C, YKR039W, YLR031W, YLR205C, YMR072W, YMR140W, YMR173W, YMR195W, YMR226C, YNL037C, YNR002C, YOL143C, YOR136W, YOR215C, YOR382W, YOR383C, YPL054W, YPL271W, YPR127W, YAL044C, YAL054C, YAR010C, YAR027W, YAR071W, YBL001C, YBL043W, YBL057C, YBR014C, YBR024W, YBR035C, YBR068C, YBR111C, YBR116C, YBR147W, YBR168W, YBR246W, YBR273C, YCR004C, YCR021C, YCR037C, YCR088W, YDL022W, YDL128W, YDL238C, YDR003W, YDR009W, YDR033W, YDR084C, YDR104C, YDR270W, YDR315C, YDR340W, YDR357C, YDR358W, YDR396W, YDR405W, YDR410C, YDR434W, YDR482C, YDR487C, YDR520C, YDR534C, YDR539W, YEL011W, YEL065W, YEL066W, YER039C, YER044C, YER067W, YER080W, YER107C, YFL020C, YFL028C, YFL043C, YFR015C, YGL001C, YGL008C, YGL068W, YGL073W, YGL104C, YGL113W, YGL154C, YGL167C, YGL229C, YGL242C, YGL249W, YGL253W, YGR052W, YGR060W, YGR065C, YGR106C, YGR111W, YGR220C, YGR257C, YHL023C, YHL048W, YHR004C, YHR037W, YHR071W, YHR092C, YHR190W, YIL007C, YIL033C, YIL070C, YIL088C, YIL111W, YIR002C, YIR016W, YIR035C, YIR043C, YJL012C, YJL083W, YJL089W, YJL116C, YJL131C, YJL132W, YJL196C, YJR061W, YJR086W, YJR142W, YJR161C, YKL008C, YKL013C, YKL041W, YKL067W, YKL138C, YKL139W, YKL150W, YKL175W, YKR006C, YKR014C, YKR070W, YLL023C, YLR023C, YLR093C, YLR118C, YLR142W, YLR225C, YLR241W, YLR251W, YLR252W, YLR270W, YML030W, YML110C, YMR021C, YMR027W, YMR148W, YMR181C, YMR262W, YMR272C, YMR298W, YNL011C, YNL130C, YNL214W, YNL259C, YOL129W, YOR042W, YOR052C, YOR137C, YOR149C, YOR165W, YOR270C, YOR285W, YOR367W, YPL018W, YPL156C, YPL186C, YPL203W, YPL216W, YPL255W, YPR006C, YPR073C, YPR098C, YBR050C, YBR145W, YBR299W, YDR518W, YEL020C, YFL062W, YGL039W, YGL134W, YJL217W, YJR159W, YLR126C, YNL249C, YNL284C, YNL336W, YOL157C, YOR344C, YOR381W, YPL265W, YPR124W, YBR074W, YBR109C, YBR126C, YBR201W, YCR005C, YDL248W, YDR041W, YDR105C, YDR268W, YDR452W, YEL075C, YER046W, YER050C, YER136W, YER159C, YGL250W, YGR019W, YGR042W, YGR053C, YGR066C, YGR247W, YGR255C, YGR295C, YHL044W, YHR145C, YIL058W, YIL065C, YIL083C, YIL098C, YIL172C, YJL030W, YJL185C, YJL213W, YJR029W, YJR099W, YJR122W, YJR125C, YKL190W, YKR020W, YLL025W, YLL051C, YLR043C, YLR090W, YLR100W, YLR108C, YLR290C, YML068W, YMR051C, YMR139W, YMR178W, YMR193W, YNL015W, YNL079C, YNL122C, YNL223W, YNL285W, YNL293W, YNR007C, YNR035C, YNR061C, YOL016C, YOL104C, YOR220W, YOR221C, YOR374W, YPL123C, YPR077C, YPR107C, YPR147C, YBR093C, YBR196C, YEL041W, YEL047C, YER023W, YER119C, YFL055W, YGR209C, YIL124W, YKL187C, YLL055W, YMR318C, YOL152W, YAL007C, YBR067C, YBR115C, YBR285W, YBR292C, YDL043C, YDL123W, YDL131W, YDL168W, YDL212W, YDR056C, YDR132C, YDR154C, YDR183W, YDR216W, YDR253C, YDR295C, YDR494W, YDR513W, YEL072W, YER045C, YER061C, YER181C, YFL052W, YFL058W, YFR030W, YGL089C, YGL096W, YGL114W, YGL193C, YGL202W, YGL204C, YGL259W, YGR006W, YGR070W, YGR088W, YHL034C, YHL036W, YHR048W, YHR104W, YHR163W, YIL060W, YIL136W, YIR024C, YJL036W, YJL045W, YJL060W, YJL101C, YJL155C, YJR085C, YJR109C, YJR156C, YKL070W, YKL161C, YKL221W, YKR071C, YLL009C, YLL050C, YLR092W, YLR145W, YLR156W, YLR163C, YLR220W, YLR280C, YLR311C, YLR390W, YML116W, YMR034C, YMR038C, YMR081C, YMR250W, YNL240C, YNL260C, YNL277W, YNR074C, YOL044W, YOL084W, YOL147C, YOL159C, YOR184W, YOR228C, YOR255W, YPL223C, YPR160W, YDL182W, YBR047W, YBR054W, YBR291C, YDR069C, YER124C, YER131W, YGR044C, YIL094C, YKR007W, YMR240C, YNR050C, YOR007C, YAL015C, YBL065W, YBR105C, YBR182C, YBR186W, YBR244W, YBR272C, YCL069W, YDL025C, YDL059C, YDL085W, YDL113C, YDL244W, YDR018C, YDR054C, YDR202C, YDR223W, YDR350C, YDR353W, YDR374C, YDR512C, YEL052W, YEL070W, YER098W, YFR017C, YGL046W, YGL067W, YGL098W, YGL117W, YGL146C, YGL240W, YGR011W, YGR067C, YGR133W, YGR153W, YGR223C, YHR116W, YHR124W, YIL097W, YIL168W, YJL103C, YJL221C, YJR036C, YJR095W, YKL085W, YKL133C, YKL162C, YKL188C, YKL217W, YKR061W, YKR105C, YLL062C, YLR174W, YLR216C, YLR247C, YLR260W, YLR267W, YLR389C, YML007W, YMR041C, YMR177W, YMR253C, YNL009W, YNL117W, YNL128W, YNL183C, YNR073C, YOL133W, YOL158C, YOR133W, YOR225W, YOR227W, YPL161C, YPL166W, YPL202C, YPL224C, YPR015C, YPR086W, YPR201W, YAL061W, YAL067C, YAR007C, YBL033C, YBL056W, YBL086C, YBR026C, YBR073W, YBR101C, YBR117C, YBR123C, YBR213W, YBR269C, YBR280C, YCR036W, YDL132W, YDL149W, YDL200C, YDL234C, YDL242W, YDR099W, YDR177W, YDR256C, YDR392W, YDR394W, YDR531W, YEL071W, YER014W, YER042W, YER090W, YER184C, YFL059W, YFR042W, YFR046C, YFR049W, YGL026C, YGL058W, YGL185C, YGL227W, YGL252C, YGL254W, YGR089W, YGR112W, YGR134W, YGR276C, YHL019C, YHR012W, YHR017W, YHR028C, YHR106W, YHR109W, YHR156C, YIL036W, YIL046W, YIL143C, YIL152W, YIL159W, YIL164C, YJL071W, YJL094C, YJL154C, YJR056C, YJR072C, YJR110W, YJR139C, YKL025C, YKL034W, YKL064W, YKL171W, YKL196C, YKR012C, YKR068C, YKR069W, YLL001W, YLL057C, YLL061W, YLR064W, YLR070C, YLR099C, YLR144C, YLR157C, YLR160C, YLR164W, YLR364W, YLR421C, YML032C, YML042W, YML112W, YML118W, YMR114C, YMR115W, YMR258C, YNL181W, YNL191W, YNL212W, YNL213C, YNL250W, YNL265C, YNL312W, YNR032W, YOL038W, YOL049W, YOL064C, YOR088W, YOR155C, YOR257W, YOR265W, YOR377W, YOR386W, YPL031C, YPL113C, YPL124W, YPL151C, YPL249C, YPL260W, YPL274W, YPR048W, YPR061C, YPR093C, YPR125W, YPR158W, YPR168W, YPR169W, YPR174C, YPR180W, YPR193C, YPR200C, YAL014C, YAL017W, YAL049C, YBL019W, YBL058W, YBR001C, YBR013C, YBR018C, YBR037C, YBR045C, YBR051W, YBR063C, YBR128C, YBR129C, YBR204C, YBR241C, YBR255W, YBR281C, YCL044C, YCL055W, YCR014C, YCR019W, YCR024C, YCR105W, YDL065C, YDL089W, YDL143W, YDL173W, YDL193W, YDL197C, YDL206W, YDL230W, YDL233W, YDR040C, YDR071C, YDR078C, YDR109C, YDR140W, YDR194C, YDR212W, YDR221W, YDR257C, YDR271C, YDR287W, YDR294C, YDR316W, YDR329C, YDR338C, YDR369C, YDR421W, YDR425W, YDR485C, YDR488C, YDR504C, YDR505C, YDR506C, YDR515W, YEL005C, YEL037C, YEL044W, YER017C, YER048C, YER052C, YER078C, YER089C, YER092W, YER100W, YER162C, YER182W, YFL021W, YFL042C, YFR045W, YFR051C, YFR056C, YGL040C, YGL041C, YGL045W, YGL057C, YGL093W, YGL105W, YGL125W, YGL166W, YGL181W, YGL183C, YGL215W, YGL216W, YGL221C, YGL223C, YGR007W, YGR029W, YGR155W, YGR156W, YGR186W, YGR198W, YGR210C, YGR211W, YGR237C, YGR250C, YGR258C, YGR266W, YGR270W, YGR274C, YGR277C, YHL021C, YHL037C, YHL038C, YHR082C, YHR083W, YHR134W, YHR160C, YHR171W, YHR180W, YHR205W, YIL062C, YIL072W, YIL075C, YIL099W, YIL108W, YIL165C, YIL170W, YIR009W, YIR018W, YIR031C, YIR032C, YJL032W, YJL049W, YJL128C, YJL165C, YJR044C, YJR052W, YJR090C, YJR091C, YJR103W, YJR104C, YJR153W, YKL059C, YKL079W, YKL090W, YKL094W, YKL192C, YKL209C, YKR052C, YKR102W, YKR106W, YLL054C, YLR025W, YLR097C, YLR200W, YLR226W, YLR248W, YLR266C, YLR392C, YLR427W, YML013W, YML029W, YML041C, YML051W, YML078W, YML079W, YML088W, YML099C, YMR056C, YMR068W, YMR091C, YMR110C, YMR160W, YMR186W, YMR255W, YNL005C, YNL026W, YNL039W, YNL063W, YNL064C, YNL077W, YNL083W, YNL147W, YNL176C, YNL194C, YNL253W, YNL257C, YNL261W, YNL264C, YNL276C, YNR006W, YNR034W, YNR047W, YNR051C, YNR071C, YOL065C, YOL067C, YOR005C, YOR008C, YOR022C, YOR023C, YOR058C, YOR069W, YOR087W, YOR138C, YOR229W, YOR256C, YOR267C, YPL005W, YPL020C, YPL022W, YPL105C, YPL147W, YPL150W, YPL152W, YPL164C, YPL168W, YPL180W, YPL188W, YPL194W, YPR025C, YPR047W, YPR049C, YPR066W, YPR081C, YPR134W, YPR140W, YPR148C, YPR155C, YPR172W, YPR185W, YAL018C, YAR064W, YBR012C, YBR076W, YBR287W, YDR043C, YDR250C, YDR373W, YFR014C, YGL191W, YGR180C, YHR136C, YJL026W, YJL037W, YLR038C, YNL058C, YOR031W, YGR087C, YIL166C, YHR008C, YIL129C, YGL256W, YJR030C, YMR077C, YBR264C, YPL177C, YKR040C, YGL056C, YDR128W, YGR139W, YBL101W-A, YOR253W, YOL026C, YDR278C, YHR095W, YCL042W, YNL200C, YPL221W, YLR415C, YMR058W, YPR037C, YER072W, YML028W, YOR325W, YAL039C, YMR112C, YJR107W, YGL088W, YJR058C, YNL142W, YDR090C, YMR071C, YBL093C, YGR293C, YML055W, YDL017W, YDL210W, YGL055W, YCL025C, YDR080W, YDL181W, YNR030W, YJL017W, YIL127C, YDR281C, YDR366C, YFR026C, YJL212C, YPL215W, YEL019C, YBR132C, YHL018W, YNL196C, YPL038W, YAR047C, YPL262W, YHL006C, YPL225W, YBR124W, YOR148C, YKR053C, YBL044W, YER029C, YLR360W, YCL056C, YCR007C, YGR239C, YNL256W, YPR146C, YLR377C, YKL097C, YBR066C, YLR338W, YDL229W, YBR253W, YJR027W, YKL198C, YBL030C, YBR031W, YBR118W, YBR162C, YBR221C, YCR024C-A, YCR106W, YDL046W, YDR012W, YDR133C, YDR134C, YDR276C, YDR342C, YDR343C, YEL027W, YEL034W, YGR038W, YGR243W, YGR279C, YHR094C, YHR105W, YHR175W, YHR181W, YIL056W, YIL162W, YJL059W, YJL097W, YJL158C, YJR105W, YKL051W, YKL056C, YKL097W-A, YKL100C, YKL141W, YKR066C, YLR134W, YLR258W, YLR339C, YML058W, YMR083W, YMR203W, YNL209W, YNL307C, YOL030W, YOR178C, YPL028W, YPR028W, YPR113W, YPR149W, YPR150W, YPR183W, YAL016W, YBL099W, YBL100C, YBR011C, YBR096W, YBR100W, YBR127C, YBR283C, YBR286W, YCL008C, YCL058C, YCR030C, YCR034W, YCR069W, YDL015C, YDL023C, YDL061C, YDL086W, YDR038C, YDR039C, YDR050C, YDR151C, YDR178W, YDR233C, YDR284C, YDR298C, YDR345C, YDR359C, YDR382W, YDR385W, YDR400W, YDR407C, YDR538W, YEL024W, YEL033W, YEL063C, YER057C, YER081W, YER120W, YFL011W, YGL012W, YGL206C, YGR022C, YGR026W, YGR082W, YGR107W, YGR172C, YGR191W, YGR204W, YGR260W, YHL005C, YHL046C, YHR025W, YHR026W, YHR123W, YHR126C, YHR143W, YIL011W, YIL015W, YIL018W, YIL157C, YIR041W, YJL016W, YJL121C, YJL133W, YJL138C, YJL191W, YJR018W, YJR047C, YJR077C, YJR119C, YJR121W, YJR123W, YJR143C, YJR145C, YKL060C, YKL147C, YKL148C, YKL157W, YKL164C, YKL169C, YKR033C, YLL041C, YLL064C, YLR041W, YLR044C, YLR056W, YLR058C, YLR081W, YLR089C, YLR110C, YLR177W, YLR264W, YLR284C, YLR304C, YLR340W, YLR354C, YLR372W, YLR388W, YML022W, YMR007W, YMR011W, YMR015C, YMR092C, YMR101C, YMR156C, YMR205C, YMR215W, YMR261C, YMR323W, YNL069C, YNL135C, YNL195C, YNR076W, YOL039W, YOL073C, YOL086C, YOL120C, YOL156W, YOL161C, YOR002W, YOR009W, YOR010C, YOR085W, YOR108W, YOR128C, YOR129C, YOR142W, YOR161C, YOR176W, YOR230W, YOR298W, YPL004C, YPL036W, YPL048W, YPL057C, YPL059W, YPL061W, YPL135W, YPL179W, YPL218W, YPL220W, YPL246C, YPL272C, YPR063C, YPR080W, YPR181C, YBR290W, YCR010C, YCR091W, YDL107W, YDL129W, YDR066C, YDR529C, YFL026W, YGL018C, YGL059W, YNL144C, YOR003W, YAL037W, YAR023C, YBR003W, YBR020W, YBR044C, YBR091C, YBR185C, YBR282W, YCR015C, YCR038C, YCR043C, YDL119C, YDL146W, YDL220C, YDR057W, YDR123C, YDR125C, YDR222W, YDR225W, YDR277C, YDR286C, YDR347W, YDR408C, YDR438W, YDR479C, YDR483W, YEL039C, YEL057C, YEL073C, YER066W, YER076C, YER084W, YER121W, YER189W, YFL017C, YFL046W, YFR006W, YFR008W, YGL115W, YGL208W, YGL214W, YGL218W, YGR021W, YGR023W, YGR024C, YGR064W, YGR076C, YGR096W, YGR108W, YGR174C, YGR182C, YGR236C, YGR288W, YHL042W, YHR195W, YHR210C, YIL006W, YIL012W, YIL028W, YIL050W, YIL057C, YIL089W, YIL102C, YIL113W, YIL122W, YJL100W, YJL169W, YJL199C, YJR039W, YJR050W, YJR101W, YKL003C, YKL016C, YKL061W, YKL093W, YKL121W, YKL160W, YKL170W, YKL194C, YKR034W, YKR067W, YLR006C, YLR016C, YLR030W, YLR036C, YLR112W, YLR125W, YLR128W, YLR204W, YLR211C, YLR233C, YLR257W, YLR288C, YLR326W, YLR334C, YLR395C, YLR408C, YLR414C, YLR444C, YML050W, YML107C, YML120C, YMR031C, YMR053C, YMR073C, YMR162C, YMR204C, YMR206W, YMR284W, YNL010W, YNL025C, YNL127W, YNL139C, YNL217W, YOL116W, YOL118C, YOR053W, YOR100C, YOR103C, YOR122C, YOR150W, YOR187W, YOR251C, YOR312C, YOR327C, YOR348C, YOR352W, YOR388C, YOR394W, YPL001W, YPL033C, YPL066W, YPL148C, YPL230W, YPL275W, YPL276W, YPR005C, YPR014C, YPR192W, YPR194C, YBR005W, YER025W, YFL027C, YGL080W, YGL205W, YHL028W, YHR185C, YIL076W, YJL166W, YLR046C, YMR035W, YMR238W, YMR252C, YNL192W, YNL202W, YOL108C, YOR385W, YPR165W, YAR033W, YBL038W, YBR009C, YBR010W, YBR151W, YCL067C, YCR096C, YDL137W, YDL192W, YDR073W, YDR086C, YDR224C, YDR377W, YDR378C, YER015W, YGL187C, YHR162W, YJL167W, YJL216C, YKR009C, YLR165C, YMR197C, YNL157W, YOL002C, YOL109W, YOR180C, YPL010W, YPL233W, YBR036C, YDR297W, YGR149W, YGR224W, YNL043C, YPL067C, YPL170W, YCR046C, YDR387C, YFL050C, YGL051W, YHR132C, YIL112W, YJL141C, YKR098C, YLR052W, YLR206W, YML129C, YNL203C, YNR014W, YOL043C, YOL096C, YPR184W, YAL028W, YAL055W, YAR062W, YBL095W, YBL102W, YBR122C, YBR157C, YBR161W, YBR251W, YBR298C, YCR039C, YCR083W, YDL018C, YDL067C, YDL078C, YDL091C, YDL215C, YDL216C, YDR022C, YDR067C, YDR079W, YDR181C, YDR186C, YDR196C, YDR262W, YDR306C, YDR319C, YER188W, YGL004C, YGL035C, YGR036C, YGR062C, YGR120C, YGR131W, YGR141W, YGR167W, YGR287C, YHL024W, YHR080C, YHR097C, YIL077C, YJL046W, YJL070C, YJL096W, YJL113W, YJL146W, YJL180C, YJR019C, YJR049C, YKR058W, YLL005C, YLR078C, YLR151C, YLR271W, YLR295C, YLR351C, YLR375W, YMR023C, YMR025W, YMR135C, YMR210W, YMR267W, YMR278W, YMR293C, YNL073W, YNR037C, YNR040W, YNR072W, YOR028C, YOR316C, YOR328W, YOR363C, YPL039W, YPL040C, YPL099C, YPL107W, YPL134C, YPL138C, and YPL140C.

The base sequences of those yeast genes and the amino acid sequences of the corresponding protein are disclosed in public databases such as MIPS in Germany: Munich Information Center for Protein Sequence, and SGD in USA: Saccharomyces Genome Database, and are known via the internet.

In addition to the yeast genes as described above, genes that are homologous to the yeast genes and are derived from other species may be used in the invention. In this context, “a gene(s) that is (are) homologous to the yeast genes” means genes that comprise a base sequence having a homology of 50% or more, preferably 80% or more to the base sequences of yeast genes, and that encode a protein having the same functions as the proteins encoded by the yeast genes.

Cells as used herein may be either eukaryotic or prokaryotic cells as long as they comprise the genes as described above. Preferred cells are yeast cells.

Methods for detecting mRNA have been previously known, and any one of those methods may be used in the present invention.

As an embodiment of the invention, mRNA is detected through reverse transcription-PCR. Reverse transcription-PCR is well known in the art. See, for example, NAKABEPPU Yusaku, et al.: Cell Technology, suppl. Tips series, Modified PCR Tips, Shujunsha Co.Ltd., 1999, pp 25-43. For example, the invention comprises:

-   (1) adding a test material to the cell, and incubating the mixture; -   (2) extracting mRNA from the cell; -   (3) preparing cDNA from the mRNA via reverse transcription using     labeled nucleotides; and -   (4) hybridizing the cDNA as used as probe with the gene as described     above.

Incubation of cells may be conducted using usual media and usual temperatures. Test materials comprising a chemical substance to be tested are added to the medium, and the cells are incubated further for several hours. Concentrations of the test materials are selected to not lead to cell death. Test materials may comprise one or more chemical substances.

For methods of extraction of mRNA, it is well known that a polynucleotide having a poly T structure which is immobilized on the surface of magnetic beads or latex beads is used to trap the mRNA, and then the mRNA is washed and eluted with spine column in view of the fact that a poly A chain is attached to the 3′ terminus of mRNA, which is readily conducted using a commercially available kit such as Oligotex-dT30<Super>mRNA Purification Kit, Takara. The mRNA is reverse-transcribed with a reverse transcriptase (Super Script II Reverse Transcriptase; catalogue No. 18064-014, GibcoBRL) using fluorescence-labeled nucleotides. As such, labeled cDNAs that are introduced with fluorescence-labeled nucleotides during the reverse transcription are obtained. Reverse transcriptases and nucleotides that are labeled with Cy3-dUTP or Cy5-dUTP are also commercially available (for example, Super Script II Reverse Transcriptase; catalogue No. 18064-014, GibcoBRL). Fluorescence-labeled cDNAs are detected with a fluorophotometer.

RT-PCR is a procedure for detection and quantitative determination of an intended RNA in a form of the amplified cDNA, which comprises reverse-transcribing mRNA into cDNA with a reverse transcriptase, and conducting PCR using the cDNA as a starting material as well as specific primer sets and a thermostable DNA polymerase.

In the present step, a microarray containing the gene as described above (DNA tip) may be prepared to hybridize them with the cDNAs, thereby facilitating the efficient detections, which is a preferred embodiment of the present invention.

As another embodiment of the invention, the mRNA is detected by northern blotting. Northern blotting is well-known in the art (OGATA Nobukuni, NOJIMA Hiroshi: Genetic Engineering Keywords Book, revised 2nd ed., Yodosha, co.jp, 2000, pp 299-301). For example, the process comprises

-   (1) adding a test material to the cell, and incubating the mixture; -   (2) extracting mRNA from the cell; and -   (3) hybridizing the mRNA with the gene as described above.

Procedures of northern blotting comprises electrophoresing the RNA, transferring the pattern to a filter, and hybridizing it with a specific probe labeled with an isotope, thereby analyzing the presences and the amount of the mRNA in a sample as well as the length of the same.

In the present step, a microarray containing the gene as described above (DNA tip) may be prepared to hybridize them with the cDNAs, thereby facilitating the efficient detections.

In further another embodiment of the present invention, the detection of mRNA is conducted by detecting the production of a polypeptide encoded by the yeast gene as described above. The production of a polypeptide may be detected for example using an antibody directed to the polypeptide.

Toxic substances to be detected according to the present invention include arsenic, cadmium, mercury, 4-nitroquinolin-N-oxide, 2,4,5-trichlorophenol, γ-hexachlorocyclohexane, manganese ethylenebis(dithiocarbamate), 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile, tetramethylthiuram disulfide, Zinc N,N′-ethylenebis(dithiocarbamate), gingerol, acrolein, and dimethylsulfoxide, all of which are mutagenic.

The following examples are presented for purpose of further illustration of the invention, and such examples are not intended to be limiting the invention in any respect.

EXAMPLES Example 1

Yeast (Saccharomyces cerevisiae S288C (a SUC2mal mel gap2 CUP1)) were incubated at 25° C. on YPD medium (yeast extract 1%, polypepton 2%, glucose 2%). One of toxic chemical substances was added to the cells at logarithmic growth phase, and the cells were further incubated for two hours. Cells were cultured without any chemical substance in the same condition, and were used as control. Concentrations of the chemical substances were defined to inhibit the growth of the yeast but not lead to death.

Chemical Substances Concentrations (1) Na₂As 0.3 mM (2) CdCl₂ 0.3 mM (3) HgCl₂ 0.7 mM (4) PbCl₂ 2 mM (5) 4-nitroquinolin-N-oxide 0.2 μM (6) 2,4,5-trichlorophenol 16 μM (7) γ-hexachlorocyclohexane 1.3 mM (8) manganese ethylenebis(dithiocarbamate) 2 ppm (9) 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile 10 μM (10) Tetramethylthiuram disulfide 75 μM (11) zinc N,N′-ethylenebis(dithiocarbamate) 2 ppm (12) 8-methyl-N-vanillyl-6-nonenamide 0.82 mM (13) gingerol 1.36 mM (14) acrolein 0.20 mM (15) dimethylsulfoxide 1.41 M (16) Roundup (trademark, herbicide)¹⁾ 1500-fold dilution (17) sodium dodecylbenzosulfonate 0.02% (18) sodium lauryl sulfate 0.01% ¹⁾N-(phosphomethyl) glycinate ammonium 41.0%, surfactant 59.0%

After completion of the incubation, the culture was centrifuged to collect the cells. To the cells, sodium acetate buffer (50 mM sodium acetate, 10 mM EDTA, 1% SDS) was added, and the mixture was shaken at 65° C. for five minutes, followed by returning to room temperature, and obtaining the supernatant, of which the procedures were repeated two times. To the supernatant, ½ amount of a solution of phenol/chloroform was added, and the mixture was centrifuged to give a supernatant, which was added with an equal amount of chloroform, and the mixture was centrifuged to give a supernatant. To the supernatant, an equal amount of isopropanol containing 0.3 M sodium acetate was added, and the mixture was allowed to stand at room temperature for 30 minutes, after which the mixture was centrifuged to give a sediment of the whole RNAs. Seventy % ethanol was added to the sediment, and the mixture was again centrifuged to give a sediment, which was then dried and dissolved in water. mRNA was isolated from the whole RNAs as followings. In view of the fact that a poly A chain is attached to the 3′ terminus of mRNA, a polynucleotide having a poly T structure which was immobilized on the surface of latex beads was used to trap the mRNA, and then the mRNA was washed and eluted with spine column (Oligotex-dT30<Super>mRNA Purification Kit, Takara). Reverse transcription of the mRNA was conducted with a reverse transcriptase (Super Script II Reverse Transcriptase; catalogue No. 18064-014, GibcoBRL) using fluorescence-labeled nucleotides to give cDNAs that were introduced with Cy3-dUTP or Cy5-dUTP during the reverse transcription.

The labeled cDNAs were dissolved in TE buffer (10mM Tris-HCl/1 mM EDTA, pH8.0), and the solution was dropped on the DNA chip containing the whole genes of yeast (DNA Chip Research Inc. Japan) so that the cDNAs were hybridized on the DNA chip at 65° C. for over 12 hours. The fluoresces intensity of the DNA chip was read with a scanner, and the ratio relative to the fluorescence intensity resulting from the absence of chemical substance was estimated as the following, which is shown in Tables 1 to 9:

The level of expressed mRNA in the presence of chemical substance

The level of expressed mRNA in the absence of chemical substance

TABLE 1 Unknown protein yeast genes The level of expressed mRNA in the presence of chemical substance/The level of expressed mRNA in the absence of chemical substance Inten- yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) sity YCR102C 3.4 3.2 2.4 1.1 0.7 0.4 1.1 4.9 9.8 61.5 13.5 0.5 1.1 4.1 0.9 1.2 1.1 1.2 0.53 YDL218W 3.5 1.2 2.6 1.4 0.7 0.9 1.1 1.5 72.5 12.6 5.7 0.9 1.1 4.8 1.1 3.5 1.1 0.9 0.42 YDR533C 3.4 4.9 3.5 1.8 1.3 2.2 1.7 5.4 7.3 12.7 7.7 1.4 3.0 2.9 2.5 6.7 2.3 2.7 1.82 YGR110W 1.6 3.1 2.2 5.9 0.9 0.9 1.7 1.5 6.4 4.8 0.5 1.4 3.6 2.8 1.2 17.1 0.9 2.1 0.19 YKL071W 8.3 3.8 5.4 2.8 1.1 18.6 3.7 24.7 162.2 109.2 40.3 1.0 8.4 21.9 1.7 2.2 1.0 0.9 0.31 YLR460C 2.1 2.1 2.0 1.1 1.3 0.6 1.1 8.1 13.9 31.6 14.3 0.4 0.7 3.5 0.7 1.8 1.0 1.1 0.48 YMR090W 6.9 9.5 2.3 3.5 0.7 3.8 2.7 3.9 16.7 6.1 8.8 2.2 6.9 6.5 1.9 5.1 1.8 2.8 1.30 YOL150C 4.1 3.7 9.9 0.9 1.0 5.2 2.4 3.7 10.8 8.3 9.4 2.9 8.9 5.7 1.8 3.1 2.7 2.2 0.47 YBL048W 2.0 7.9 2.3 2.8 1.3 2.0 1.9 1.2 7.2 4.4 2.0 1.2 2.7 2.0 4.1 5.7 1.3 1.0 0.29 YBL107C 1.4 1.1 0.4 1.5 1.2 1.1 2.1 1.9 1.0 3.1 2.9 1.4 2.6 2.5 1.4 1.5 0.9 1.4 1.03 YFL024C 1.0 1.1 1.1 0.7 1.1 2.0 3.3 0.9 0.5 0.5 0.6 0.8 0.9 3.3 0.9 1.1 0.9 0.8 0.37 YGL121C 2.6 5.0 1.4 4.2 0.9 9.8 4.7 3.0 7.0 15.0 6.1 1.6 7.8 5.8 1.6 8.5 2.7 3.5 0.60 YHR029C 2.8 1.8 1.8 1.8 1.0 2.7 2.0 2.7 13.6 8.6 3.8 1.5 4.7 3.5 1.0 1.0 2.1 2.1 0.87 YHR209W 2.8 1.1 0.8 4.5 1.8 3.2 5.0 2.0 2.9 6.4 3.3 1.0 2.0 2.2 5.0 3.5 2.6 2.6 0.56 YKL107W 2.4 2.5 0.5 0.8 1.1 2.0 1.1 0.9 28.2 8.3 2.0 1.0 1.9 3.4 1.7 3.5 1.6 0.9 0.17 YKR075C 1.5 0.7 2.7 4.5 1.2 1.5 1.4 2.0 0.2 0.6 1.3 2.3 3.8 2.7 0.4 4.3 2.4 1.9 1.15 YLL056C 2.1 2.3 3.0 2.0 1.1 0.6 1.0 1.3 58.8 8.8 1.7 1.3 6.8 11.0 1.5 4.8 5.3 2.5 0.32 YLR297W 2.4 2.1 3.5 1.7 1.3 0.8 1.1 1.3 2.1 5.5 3.5 0.8 0.8 2.3 0.7 1.8 0.7 1.0 0.81 YOR338W 1.8 1.8 0.5 1.7 1.6 2.6 1.3 2.2 0.6 3.5 0.8 1.2 1.4 2.5 1.8 1.0 1.1 0.5 0.52 YOR391C 2.1 2.0 0.9 1.2 1.3 1.6 2.0 2.8 18.8 18.1 3.2 1.1 2.3 2.4 5.8 2.2 1.0 0.9 0.22 YPL280W 1.7 1.9 1.9 2.0 1.4 1.9 1.8 2.3 49.8 14.0 1.9 0.9 2.4 2.4 4.3 1.5 1.2 0.9 0.22 YLR346C 4.4 2.0 2.1 4.5 1.4 5.5 5.6 1.3 8.6 6.6 0.5 4.2 6.2 2.2 1.0 2.4 10.6 7.8 0.53 YOR049C 2.5 0.9 12.8 1.4 1.3 8.4 4.2 0.9 1.1 1.9 1.1 6.7 7.1 1.5 1.3 4.3 2.6 2.9 0.22 YAL034C 1.1 1.8 2.8 1.1 1.0 1.5 1.8 1.0 3.0 3.3 1.5 2.8 4.9 1.2 1.4 1.0 1.2 1.3 0.52 YDR476C 0.7 1.8 6.0 1.2 0.5 3.1 1.5 1.3 1.7 3.4 1.6 2.1 2.8 1.1 2.2 2.0 2.4 1.5 0.58 YGR035C 1.6 0.6 1.2 0.6 1.3 3.3 1.1 0.9 1.1 0.5 0.4 3.3 2.1 0.8 0.3 1.9 2.5 4.3 1.04 YGR284C 1.0 2.0 4.0 1.4 1.2 1.4 2.2 1.1 4.3 1.8 1.7 2.1 3.6 1.2 3.9 1.9 1.3 2.1 2.57 YHR054C 1.7 0.9 2.2 1.0 1.0 2.9 1.6 1.8 2.6 7.7 0.9 3.6 5.8 1.0 0.8 2.2 5.1 3.4 0.80 YLR008C 0.9 0.5 0.7 0.9 1.3 2.7 2.0 1.0 0.4 0.7 0.8 3.5 6.2 1.6 0.7 1.7 5.4 4.9 2.00 YMR315W 4.3 1.8 1.7 4.2 2.9 2.0 2.4 2.6 3.2 2.0 2.5 1.3 2.5 1.6 2.1 2.8 1.76 YNL211C 1.2 1.0 0.8 1.0 1.0 7.4 3.1 1.1 0.8 1.1 1.1 3.2 9.9 1.1 0.8 9.3 4.2 6.8 0.52 YOL031C 0.9 1.9 1.0 1.7 1.2 1.0 2.5 2.1 2.3 1.4 1.3 2.1 2.4 1.1 4.4 1.5 1.2 1.9 1.20 YOL101C 0.9 0.8 0.4 1.7 1.6 0.5 0.7 0.9 0.1 0.3 0.9 2.4 0.2 0.8 0.6 3.5 0.6 0.6 1.37 YAR031W 1.5 1.1 1.1 1.7 1.1 2.9 1.6 1.2 2.7 1.6 1.4 1.2 3.3 1.4 0.9 3.5 1.6 2.5 1.00 YBL049W 2.9 11.8 2.1 2.9 1.1 1.7 1.9 5.2 5.2 2.2 0.7 3.9 1.5 7.2 6.4 1.1 1.1 0.47 YBR062C 1.3 1.7 0.4 1.2 1.4 1.9 1.5 1.9 5.4 2.2 2.3 1.2 2.8 2.6 0.7 2.2 1.4 1.6 0.93 YCR013C 1.3 1.4 5.0 1.1 1.1 1.8 1.6 0.7 0.8 1.3 2.4 1.4 3.9 1.5 1.6 1.6 1.1 1.3 2.80 YDL027C 1.2 2.0 1.7 1.7 1.2 2.1 2.9 1.5 2.0 2.3 1.7 1.7 3.2 1.1 1.4 1.8 1.4 2.0 0.69 YDL110C 1.5 1.4 1.1 2.1 0.8 1.7 2.5 1.8 3.0 2.3 1.9 1.5 2.7 2.7 1.3 3.6 2.0 4.4 1.27 YDL169C 1.7 1.7 1.1 1.3 1.1 2.6 2.1 1.3 7.3 4.7 1.2 1.2 3.7 2.7 2.2 3.8 1.5 1.6 0.42 YDR070C 2.2 6.4 3.6 3.5 0.9 6.2 1.4 1.9 13.9 6.0 4.1 4.3 6.6 2.0 2.1 15.1 1.2 3.1 0.44 YDR210W 1.1 1.0 0.9 1.0 2.0 1.2 1.5 1.4 0.5 1.0 1.0 1.0 2.3 1.1 1.0 1.5 1.9 1.9 1.82 YDR214W 1.3 4.0 4.5 1.3 1.1 1.7 1.5 1.5 5.5 2.4 1.9 1.1 5.3 1.2 1.1 0.7 1.2 1.0 1.07 YDR435C 1.2 1.1 1.2 1.4 1.2 2.5 2.1 1.2 0.8 2.1 1.3 1.1 2.5 1.3 0.6 2.0 1.3 2.0 1.30 YER037W 2.0 2.1 0.8 1.1 1.3 3.2 2.6 1.0 1.0 5.5 1.5 1.2 3.0 1.7 0.8 1.8 1.7 2.6 1.17 YFL044C 1.0 1.5 0.8 2.3 1.6 1.3 1.6 1.4 5.2 3.7 2.2 1.2 4.7 1.2 1.0 1.8 1.3 1.4 0.50 YFR003C 1.2 1.5 0.8 1.6 1.0 2.2 1.4 1.4 8.3 3.1 1.4 0.9 2.5 2.1 1.0 1.4 1.3 1.8 1.01 YFR020W 1.0 0.9 1.2 1.0 0.9 1.4 1.1 0.9 3.7 3.5 1.4 0.9 2.3 1.8 2.6 1.0 1.2 0.9 0.61 YFR044C 0.9 1.3 3.8 1.1 0.9 2.1 1.2 0.8 2.1 2.2 1.9 1.2 3.1 0.8 1.5 1.2 1.0 1.0 1.99 YGR010W 1.2 1.6 0.9 1.2 0.8 1.2 1.7 1.6 13.6 8.9 1.5 0.9 5.2 1.9 1.3 1.4 0.8 1.3 0.55 YGR142W 2.7 6.2 15.3 1.3 1.3 0.9 1.4 1.5 36.8 12.2 2.3 2.0 8.9 0.9 1.3 0.3 1.9 1.5 1.28 YGR161C 2.0 2.2 5.4 3.8 1.0 1.4 1.4 1.3 2.0 3.8 0.8 1.7 2.8 0.9 1.7 1.1 1.5 1.8 0.65 YGR212W 1.5 1.7 1.5 1.3 1.2 1.0 1.1 3.8 0.9 1.5 10.0 1.1 1.1 2.1 3.9 2.2 0.28 YGR268C 1.1 2.3 2.0 2.5 1.1 1.1 1.0 1.1 4.1 1.6 0.8 1.0 2.8 1.0 1.5 1.2 1.5 1.4 0.48 YHR016C 0.8 1.5 1.7 1.5 1.8 3.7 0.8 2.8 2.0 2.2 1.3 3.3 0.9 0.6 2.1 1.2 1.4 0.51 YHR087W 1.2 2.7 8.6 2.8 0.7 4.2 3.4 1.2 4.1 3.9 3.7 1.4 4.0 1.5 1.9 3.8 1.2 2.9 1.34 YJL048C 1.7 2.5 2.0 2.9 0.9 1.5 0.7 1.5 1.2 3.8 3.2 1.1 2.4 1.7 0.6 2.3 1.6 2.5 0.82 YJL144W 1.9 1.6 2.2 1.6 1.2 1.7 1.7 1.3 14.6 8.9 3.0 0.8 3.9 1.6 1.0 2.5 2.2 2.4 0.60 YJL163C 1.2 1.9 1.7 1.5 0.9 2.8 2.3 0.7 14.5 2.5 3.1 2.0 4.5 1.0 2.0 2.8 1.5 1.7 0.28 YJR074W 1.0 1.4 2.0 2.0 0.7 1.2 1.8 1.3 3.7 3.1 1.2 2.0 2.8 1.7 3.4 1.5 1.8 1.9 0.68 YKL065C 1.9 2.0 1.3 1.7 1.0 2.3 3.8 1.8 3.1 3.9 1.3 1.3 3.0 2.1 1.7 2.8 2.8 4.6 2.29 YKR011C 1.1 1.6 0.9 1.6 1.2 2.3 2.7 2.0 4.7 4.4 1.5 1.1 3.5 1.4 1.8 1.3 1.3 1.9 0.66 YKR018C 0.7 1.1 1.7 0.7 0.9 1.7 1.0 0.7 3.9 1.7 1.4 1.0 3.0 1.1 1.0 1.8 1.0 1.2 0.98 YKR046C 1.9 7.8 2.8 1.8 0.6 1.9 1.3 0.8 3.9 2.0 2.6 1.3 2.8 1.9 2.9 3.5 1.2 1.9 0.73 YKR049C 1.6 4.2 1.0 3.2 0.9 3.0 2.4 1.3 2.2 3.2 2.2 1.2 4.1 2.1 0.9 4.2 1.6 3.3 1.17 YLR132C 1.0 1.1 0.3 1.1 1.2 1.1 1.1 0.7 4.5 2.5 0.5 1.0 2.7 1.3 2.3 1.6 1.2 1.6 0.36 YLR161W 0.9 0.8 0.8 0.7 0.9 1.2 1.3 0.8 1.0 1.5 1.5 0.8 2.1 1.0 0.6 1.1 1.1 0.9 0.33 YLR217W 0.9 2.0 2.1 0.7 1.4 1.4 1.5 1.0 3.2 8.2 0.9 3.8 0.9 0.9 0.8 1.0 1.2 0.35 YLR328W 1.3 1.2 1.3 0.9 0.9 4.8 5.4 1.1 0.9 1.2 1.4 1.2 4.3 0.5 0.8 1.4 1.1 0.8 1.04 YML128C 1.5 3.3 4.1 4.1 0.5 5.1 2.8 1.1 5.1 3.1 2.9 1.4 4.9 1.4 2.6 5.6 2.0 5.5 1.66 YMR040W 3.1 2.9 0.9 2.8 1.7 2.8 5.1 1.7 1.4 1.4 1.5 2.1 5.2 1.8 2.0 2.7 3.1 3.7 0.62 YMR251W 1.3 1.3 1.8 0.6 2.2 1.6 3.1 1.7 3.1 11.6 2.8 1.2 2.5 1.5 0.4 1.3 1.5 0.9 0.20 YMR322C 2.0 4.3 1.5 2.9 1.4 1.8 1.7 2.1 21.3 10.3 3.2 1.1 2.1 2.7 3.6 1.8 1.4 0.8 0.18 YNL094W 0.9 1.4 1.1 1.0 1.4 2.9 1.2 2.0 3.5 2.6 1.7 1.2 3.4 1.0 1.5 1.5 1.1 1.3 0.66 YNL134C 2.3 6.0 4.5 0.9 1.7 1.4 1.5 3.2 6.1 5.9 5.0 1.1 3.1 1.4 0.8 2.1 1.3 2.0 2.51 YNL155W 1.1 1.2 1.1 0.9 1.4 3.0 1.3 1.7 5.8 2.7 2.2 1.1 4.4 2.1 2.0 2.0 1.1 1.6 1.89 YOR059C 1.2 1.2 0.4 0.9 1.4 1.1 2.2 1.3 7.6 4.6 1.0 1.0 3.3 2.2 3.5 1.8 1.3 1.7 0.71 YOR152C 4.5 2.5 3.4 2.9 0.8 4.5 3.2 1.2 10.0 5.0 2.7 2.9 7.4 1.7 3.6 2.1 4.0 2.2 0.42 YOR173W 0.7 2.3 6.3 2.0 0.9 3.5 4.9 1.4 5.2 3.7 2.3 1.9 3.8 2.8 0.7 5.7 1.7 3.8 0.54 YOR289W 1.6 1.5 1.0 2.0 1.2 4.2 6.1 2.4 2.4 1.7 2.6 1.5 4.3 2.0 1.6 3.0 2.3 3.9 0.74 YPR030W 1.7 1.4 1.4 1.0 1.2 1.3 1.2 0.9 2.5 2.4 1.2 1.4 3.2 1.5 1.5 3.1 1.4 2.1 0.30 YAL008W 1.4 2.4 2.0 2.4 0.7 1.6 1.9 1.3 1.8 1.5 2.2 1.3 2.2 2.6 0.9 4.2 1.4 1.9 1.04 YBR053C 1.0 1.6 2.4 2.4 1.6 2.7 4.1 1.2 2.9 2.1 2.3 1.1 2.4 1.0 0.7 2.8 1.9 2.4 1.25 YBR099C 1.0 1.4 7.2 1.8 1.0 0.5 0.9 1.5 3.4 12.9 0.4 1.0 2.1 1.6 0.8 0.5 0.8 0.9 0.47 YBR137W 1.1 2.2 1.4 3.5 0.9 2.4 2.7 2.0 2.2 1.8 2.4 1.4 2.1 1.8 0.6 2.8 1.4 2.6 1.40 YBR203W 1.4 1.4 1.6 2.4 0.9 0.6 0.9 1.3 1.1 1.8 1.3 1.6 2.4 1.3 1.0 18.0 1.4 2.2 0.38 YCL049C 1.9 1.3 1.4 1.2 1.6 2.3 2.1 1.0 2.0 1.9 1.6 1.4 2.4 1.8 1.4 2.1 1.4 1.4 0.86 YCR082W 1.4 1.2 0.7 1.2 1.3 1.3 1.5 1.5 4.3 2.3 2.0 1.0 2.0 2.4 1.6 2.2 1.2 1.7 1.62 YDL054C 1.3 2.2 2.7 1.1 1.2 1.2 0.9 0.7 3.5 2.1 2.1 1.1 2.7 1.2 1.0 1.0 1.0 1.0 0.92 YDL115C 1.4 1.0 0.5 1.8 0.8 1.5 1.8 1.6 6.6 3.6 1.8 1.1 1.9 2.3 1.2 1.6 1.3 1.8 0.83 YDL144C 0.8 0.9 1.2 1.5 1.0 1.8 1.0 0.9 3.6 1.2 1.9 1.0 2.1 1.2 1.0 1.1 0.9 0.9 0.52 YDL223C 0.7 1.1 5.0 2.5 0.9 0.8 1.0 0.3 3.8 1.5 5.2 1.0 3.1 1.3 3.1 7.2 0.9 1.0 0.32 YDR032C 1.7 2.2 3.5 2.5 1.4 2.7 2.8 2.4 3.1 2.9 3.3 1.8 2.9 2.8 1.3 3.8 1.9 3.5 3.50 YDR330W 0.8 1.5 1.2 0.8 1.2 2.3 1.3 1.1 3.9 2.6 0.9 1.0 2.2 1.1 1.6 1.4 1.5 1.3 0.53 YDR411C 0.9 2.8 1.8 1.2 1.6 0.8 2.0 0.9 0.7 1.0 1.3 1.5 1.9 0.8 4.1 1.5 1.5 1.3 0.56 YDR511W 1.3 1.7 0.9 2.3 1.0 2.0 1.5 1.7 2.5 2.2 1.2 0.8 3.1 2.2 0.8 2.2 1.3 1.5 0.66 YDR545W 0.6 1.2 0.6 0.7 1.4 1.0 1.2 0.6 1.8 0.7 0.7 0.9 2.0 0.7 0.9 0.9 0.9 0.9 1.06 YER004W 1.0 1.5 1.9 1.4 1.5 1.2 1.4 1.1 4.5 2.9 2.2 1.7 4.6 1.8 1.4 2.3 1.4 1.2 1.48 YER035W 1.4 1.6 1.6 1.9 1.5 0.9 1.9 1.2 1.2 1.4 1.4 1.1 1.9 1.0 0.9 2.1 2.2 2.1 0.85 YER079W 1.1 1.6 1.9 2.0 0.8 1.5 1.9 1.4 5.3 3.4 2.1 0.9 2.1 1.6 0.5 1.4 1.0 1.6 0.69 YER158C 1.2 0.9 0.9 3.1 0.8 0.7 1.2 0.9 2.1 1.6 2.3 1.0 3.1 0.9 0.6 1.6 1.6 1.2 0.61 YER163C 1.1 2.4 1.2 1.6 0.8 2.0 1.5 1.4 5.4 3.4 1.6 1.0 2.9 1.9 1.6 2.4 1.2 1.2 0.62 YER175C 0.9 1.2 1.3 2.2 0.9 0.8 2.3 1.1 1.9 11.5 1.1 0.9 4.3 1.1 1.3 2.8 0.9 1.2 0.53 YFL006W 0.8 2.8 1.6 1.0 1.4 1.2 1.0 1.0 3.2 1.7 1.2 1.2 3.1 1.7 2.4 1.1 1.0 0.8 0.82 YFL010C 1.0 4.8 1.3 1.0 1.3 1.9 1.5 1.0 3.1 1.4 1.4 1.5 3.3 1.4 1.7 1.4 1.9 1.6 0.77 YFL032W 0.4 1.5 1.6 0.8 0.9 0.6 1.1 0.4 0.5 0.6 1.1 0.7 2.4 0.6 2.0 0.7 1.7 0.8 1.62 YGL037C 1.5 2.7 6.5 2.1 0.9 1.3 2.9 1.2 2.1 1.6 3.9 0.8 2.3 1.0 0.8 1.5 1.3 2.6 4.58 YGL047W 1.0 1.9 1.6 2.3 1.3 1.5 1.7 1.1 4.5 5.7 1.9 1.1 2.6 2.3 1.7 2.9 1.1 1.2 0.97 YGL053W 1.5 1.5 1.2 2.5 2.0 2.7 3.7 1.2 3.3 2.4 1.3 1.3 3.3 1.1 1.1 3.9 2.2 3.7 1.26 YGL199C 1.1 1.7 1.7 1.0 0.7 0.7 1.3 0.7 0.1 0.9 2.0 0.8 1.6 1.6 1.2 1.0 0.36 YGR101W 1.0 1.3 1.2 1.1 1.2 0.9 1.5 0.8 4.0 1.4 2.0 1.0 2.4 0.9 1.1 2.0 1.0 1.1 1.04 YGR130C 0.9 0.7 0.6 1.6 1.4 0.9 1.3 0.9 2.0 1.5 0.8 0.7 1.9 0.9 1.2 2.2 1.3 1.6 0.78 YGR154C 1.8 2.9 2.2 0.5 1.2 1.4 2.0 1.7 25.2 9.1 1.5 0.9 2.5 2.2 0.7 2.0 1.0 1.2 0.36 YGR221C 0.9 2.2 0.9 1.4 0.9 3.0 1.2 1.1 0.7 0.5 1.6 2.3 1.4 1.5 2.7 1.3 1.3 0.29 YHR138C 2.8 1.8 2.2 2.8 1.5 3.8 3.0 1.4 5.3 4.6 1.6 1.8 4.0 3.4 2.2 3.3 5.0 7.1 1.89 YHR199C 1.9 2.0 3.2 2.0 1.2 1.1 1.1 1.0 8.6 6.0 1.9 1.1 2.1 2.0 2.8 3.3 1.1 0.9 0.63 YIL041W 1.0 1.2 2.1 1.3 0.5 1.0 0.8 0.9 1.8 1.4 1.4 1.0 2.3 1.3 1.3 0.7 0.8 1.1 1.33 YIL087C 1.3 1.9 3.4 1.6 1.4 4.1 1.8 1.1 2.4 1.8 2.8 1.1 2.4 1.3 0.4 5.6 1.7 1.6 0.68 YJL057C 1.5 1.2 1.6 1.7 1.5 1.4 2.7 1.5 7.3 6.1 2.0 1.0 2.5 1.6 1.4 1.9 1.4 1.5 0.51 YJL066C 0.9 1.2 1.2 2.5 0.8 1.4 1.6 0.8 2.0 2.1 0.8 1.0 2.2 1.0 1.3 2.8 1.4 1.5 0.43 YJL082W 1.4 0.8 2.4 1.1 1.7 0.2 0.4 0.9 1.4 2.9 1.0 1.3 2.1 0.5 3.2 0.2 0.6 0.3 2.07 YJL151C 1.0 2.4 3.2 1.2 1.3 2.2 1.4 0.8 0.5 1.6 1.0 1.3 2.4 1.3 1.0 2.5 3.5 2.4 1.69 YJL152W 0.9 1.5 1.8 1.3 1.6 1.5 1.2 0.7 0.3 1.0 1.0 1.0 1.8 1.4 0.8 1.6 2.5 1.7 0.80 YJL161W 1.7 2.2 1.5 4.6 1.1 8.0 3.6 1.4 3.1 2.1 3.7 1.0 2.5 2.2 0.6 4.4 1.9 2.1 0.44 YJL171C 2.3 0.7 2.8 1.4 1.0 2.7 1.4 0.9 1.0 1.7 2.2 1.0 2.9 1.0 1.8 1.0 3.6 2.9 1.94 YJR008W 1.6 1.5 1.2 1.7 1.4 2.2 2.9 1.1 1.8 1.9 1.4 1.3 2.0 1.2 0.9 3.3 1.5 2.7 0.87 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2.6 1.9 1.1 0.8 2.5 1.0 1.6 3.1 1.6 2.6 0.80 YNL156C 1.1 1.2 0.9 1.3 1.6 1.3 1.9 1.2 2.4 1.9 1.4 0.9 2.0 1.4 1.8 2.1 1.8 1.9 1.85 YNL234W 1.1 1.1 0.6 1.8 1.7 1.3 1.2 1.3 2.6 3.3 1.3 1.1 2.5 1.5 1.4 2.6 1.0 1.0 0.49 YNL281W 1.0 1.3 2.0 1.4 1.7 0.9 1.2 1.2 2.8 1.6 1.6 0.7 2.0 1.2 1.2 0.5 0.9 0.9 1.79 YNL305C 0.9 2.2 2.7 1.4 1.3 1.1 1.7 0.7 2.9 2.1 1.8 1.1 2.6 1.3 1.6 2.5 1.7 1.6 1.35 YNR068C 1.2 1.5 2.3 2.6 1.7 0.4 1.8 1.1 6.7 14.4 1.1 1.3 3.7 1.8 1.0 1.4 1.0 1.0 0.24 YOL032W 1.3 0.8 2.0 1.3 1.4 2.1 1.4 1.5 4.5 3.0 1.4 1.0 2.3 1.3 0.9 2.4 1.7 1.8 0.77 YOL036W 0.8 0.9 1.3 0.8 1.2 1.2 1.0 0.8 3.1 2.8 2.2 1.0 2.5 1.0 2.0 1.0 1.1 0.9 0.48 YOL047C 1.4 1.1 1.1 2.5 1.4 1.5 1.3 1.1 0.6 2.3 0.9 0.8 2.0 1.2 12.3 1.3 1.5 1.0 0.19 YOL071W 1.3 2.0 1.7 2.0 0.9 1.7 2.0 1.6 4.4 2.3 4.3 1.0 2.5 2.5 0.7 4.6 1.3 2.0 1.08 YOL082W 1.0 1.6 1.6 2.1 1.5 1.8 2.5 1.1 3.4 2.0 1.6 1.0 2.4 1.4 1.0 2.4 1.6 2.5 0.60 YOL083W 1.1 2.3 1.2 2.8 1.4 4.5 3.1 1.3 2.7 2.3 1.3 1.2 2.3 1.4 1.0 3.8 1.4 3.2 0.41 YOL117W 1.0 1.1 0.5 1.4 1.7 2.0 1.6 1.1 1.3 4.1 1.0 0.9 2.2 1.7 1.1 2.2 1.3 1.4 0.21 YOL131W 1.0 1.5 0.6 1.0 1.5 1.1 1.3 1.1 8.4 8.1 1.4 0.9 3.1 2.3 1.4 0.7 1.1 0.9 0.15 YOL162W 2.0 6.9 1.7 1.4 0.9 1.2 2.0 1.6 12.0 6.8 4.3 1.4 3.8 1.4 0.6 0.9 1.2 0.9 0.26 YOR019W 2.9 1.2 0.8 4.7 1.4 1.3 2.8 1.1 3.5 7.1 1.7 1.0 2.2 1.4 0.7 2.6 1.7 2.8 0.40 YOR197W 0.8 1.0 1.1 1.4 0.6 1.3 0.9 0.9 0.8 0.7 1.0 1.0 2.1 0.7 1.7 1.0 1.5 1.5 1.30 YPL087W 1.0 5.1 3.0 7.3 0.6 4.3 4.2 1.0 1.0 2.2 2.5 1.8 4.4 1.2 1.3 1.8 2.1 2.7 1.49 YPL196W 1.3 1.6 1.3 1.7 1.5 2.0 2.4 1.2 10.9 2.8 1.7 0.9 2.1 1.6 0.7 4.3 1.4 2.3 0.92 YPL206C 1.0 2.9 1.4 1.9 0.7 1.8 1.2 1.0 1.7 1.1 1.5 0.8 2.5 1.1 0.8 1.2 1.4 1.9 1.22 YPL222W 0.9 3.5 0.8 1.3 1.2 2.2 1.1 0.7 7.4 3.4 1.2 1.3 3.0 1.1 0.9 2.2 1.1 0.9 0.26 YPR023C 1.2 1.4 1.2 0.8 1.1 1.4 1.2 0.9 4.4 2.8 1.7 0.9 2.0 0.9 0.8 1.4 1.0 1.1 0.81 YPR151C 2.3 2.0 1.5 4.1 1.3 1.6 4.4 1.4 3.0 9.5 1.4 0.9 2.0 1.4 0.7 2.8 1.3 1.4 0.16 YDL222C 0.9 1.1 1.5 3.9 1.0 1.4 1.0 0.7 1.9 1.0 2.6 1.0 2.2 1.3 7.1 6.5 0.9 1.3 0.50 YEL001C 1.0 1.0 1.4 0.7 0.9 1.3 1.1 1.2 2.0 1.2 1.2 1.1 0.9 1.3 3.0 1.2 0.7 1.3 2.81 YER106W 1.3 0.7 1.3 1.2 1.6 1.1 1.0 1.2 0.4 1.8 1.0 0.9 1.0 1.5 6.8 0.9 0.8 0.8 0.25 YIL023C 1.1 1.2 2.1 1.8 1.3 0.9 1.2 0.7 3.5 1.6 1.1 0.9 1.1 0.7 5.6 1.1 1.2 1.0 0.93 YJR054W 0.8 0.9 0.3 0.9 1.0 0.7 0.9 1.6 0.6 0.7 0.9 0.4 1.2 3.1 0.6 0.9 0.9 0.52 YKL086W 1.0 1.1 2.4 2.6 0.8 1.0 0.7 1.1 8.2 20.5 0.7 0.6 1.3 2.9 5.0 0.6 0.9 1.0 0.28 YKR091W 1.5 2.3 0.9 3.5 1.6 1.0 1.3 1.3 1.0 1.6 1.1 0.9 1.0 1.9 6.3 1.6 1.6 1.3 0.45 YLR194C 2.1 2.2 1.3 3.6 1.0 0.9 1.0 1.0 0.9 1.1 1.4 1.6 4.0 1.2 3.6 0.9 1.0 0.9 0.60 YMR095C 1.1 2.0 1.6 1.0 0.9 0.7 1.2 1.2 1.4 2.1 0.8 3.4 2.2 41.7 1.0 1.0 1.0 0.23 YAL053W 0.9 0.9 1.3 2.1 0.8 1.1 0.7 0.8 1.4 0.9 2.3 0.6 1.1 0.7 2.9 1.1 1.2 1.6 1.60 YDL072C 1.3 1.1 3.5 2.1 1.4 1.5 1.8 0.8 1.1 1.5 1.4 1.2 1.6 1.8 2.6 2.6 1.6 2.8 3.25 YDL204W 1.4 1.9 4.8 3.4 1.0 5.6 3.2 1.1 2.3 2.0 3.2 0.9 3.2 2.4 3.6 8.6 1.8 2.7 0.73 YDR391C 1.2 2.0 1.3 1.6 1.2 2.8 2.0 1.4 1.5 2.7 1.9 1.4 1.8 2.3 3.5 3.0 1.8 2.4 1.05 YIL024C 1.4 1.3 1.1 2.1 1.3 1.0 1.3 1.1 2.2 1.8 0.6 0.7 1.0 1.5 3.1 1.0 1.1 1.0 0.35 YIL117C 2.5 1.2 1.0 3.3 0.8 1.2 1.5 1.8 2.3 3.5 1.8 1.4 1.3 2.6 7.5 1.0 2.6 2.6 1.22 YJL108C 1.2 1.2 1.0 2.2 1.5 0.6 0.6 1.0 0.3 0.7 1.0 0.4 0.5 1.0 4.0 0.6 1.0 0.9 0.40 YJL149W 1.2 1.8 1.5 6.8 0.8 0.7 1.3 1.0 1.5 3.8 1.5 1.1 1.9 1.1 9.0 1.4 0.8 1.2 0.28 YJL186W 0.6 0.9 1.2 0.8 0.7 0.7 0.6 0.6 0.2 0.5 0.6 0.6 0.4 0.8 2.5 1.0 0.7 0.8 1.07 YNL190W 1.0 1.4 2.6 0.9 1.0 0.5 0.8 0.8 1.1 1.1 1.0 1.0 1.3 0.6 2.6 1.3 0.7 0.8 4.72 YNL208W 1.5 3.2 2.9 2.1 1.2 1.4 0.9 1.5 2.3 3.1 2.5 0.8 1.7 1.0 2.6 0.9 1.0 1.0 1.55 YNL300W 0.7 0.3 2.9 1.5 0.9 0.4 0.4 0.9 0.2 0.9 0.8 0.7 0.8 3.3 1.0 1.0 0.8 0.39 YNR064C 0.9 0.6 0.9 1.8 1.5 2.1 0.8 0.9 2.1 0.7 0.7 1.6 0.8 6.1 1.4 1.1 1.9 2.17 YOR248W 2.4 0.7 2.9 1.3 0.7 0.2 0.3 0.7 0.1 0.4 2.3 0.5 0.4 0.5 8.8 0.3 1.0 0.8 2.47 YPL052W 1.8 1.7 0.4 1.0 1.7 1.9 1.4 1.7 2.0 4.8 1.2 1.1 1.6 3.2 3.3 1.1 1.3 1.5 0.88 YPR079W 1.0 1.8 1.3 1.5 0.9 1.0 2.3 1.1 1.7 2.8 0.8 1.0 1.3 1.3 2.9 1.9 1.4 1.5 0.42 YAR028W 1.2 1.0 0.7 1.2 0.9 3.3 1.8 1.3 1.0 0.9 0.9 0.8 1.4 1.2 0.9 1.5 1.9 2.1 1.40 YDR031W 1.5 1.1 1.7 1.5 1.2 3.6 1.9 1.4 1.1 2.7 1.2 0.9 1.3 2.5 0.8 2.4 1.3 2.5 1.23 YDR486C 1.1 1.5 1.2 0.9 1.2 2.7 1.8 1.8 2.5 5.8 1.4 1.3 1.7 2.4 1.1 2.6 1.1 1.7 1.18 YER038C 1.2 1.4 0.6 1.2 1.4 2.8 1.5 1.1 0.7 2.5 0.6 0.9 2.2 1.3 0.8 1.6 1.2 1.4 0.51 YGL136C 1.1 1.0 1.2 1.1 1.0 3.1 0.7 1.1 1.3 1.0 1.4 1.1 1.1 2.3 0.9 1.4 1.3 1.1 0.64 YGR146C 1.6 2.0 2.0 2.0 0.9 4.1 2.7 1.4 0.8 3.8 0.9 1.4 1.7 1.3 1.4 1.8 1.3 0.9 0.75 YJL020C 0.7 1.2 0.8 0.8 1.0 2.1 1.3 0.6 1.3 1.0 0.6 0.7 1.6 1.2 1.4 0.8 2.0 1.3 0.95 YLR031W 1.3 1.0 0.7 1.3 1.3 3.0 1.5 0.9 0.9 1.4 0.7 1.0 1.6 1.5 0.7 1.6 1.2 1.2 0.30 YLR205C 1.2 5.1 0.7 1.3 1.3 4.4 9.0 1.7 1.5 5.7 0.4 1.3 1.4 2.4 2.5 2.3 2.0 1.4 0.29 YMR140W 1.0 0.9 1.2 0.7 1.1 17.1 4.3 0.8 1.8 2.3 0.7 0.9 1.6 1.2 1.4 2.8 1.4 2.0 0.54 YMR195W 1.7 3.1 1.2 2.2 1.1 2.6 1.1 1.0 0.2 0.7 1.1 0.9 0.7 1.3 0.6 2.5 1.6 2.2 1.28 YOR215C 1.5 1.3 0.7 1.8 1.8 2.6 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1.6 1.3 0.9 1.1 0.44 YJR072C 0.7 2.5 1.0 0.8 1.1 0.7 0.8 1.3 3.1 1.6 0.9 1.0 1.1 1.2 0.6 0.9 0.8 0.8 0.78 YKL034W 0.8 1.4 1.0 0.9 1.1 1.9 1.4 0.7 2.6 3.7 1.2 1.0 1.9 1.0 1.6 1.5 1.3 1.2 0.41 YKR012C 0.7 1.4 1.0 1.0 1.2 1.4 1.0 1.0 3.9 1.2 0.8 0.7 1.5 1.4 1.2 0.9 1.0 0.9 0.61 YLR064W 1.1 1.1 2.9 1.3 0.8 1.2 0.8 1.0 3.3 2.1 1.6 0.7 1.6 1.4 1.5 1.0 0.9 1.0 1.49 YLR364W 3.3 8.0 1.2 1.5 1.3 1.0 1.0 1.1 8.3 1.3 1.5 0.7 1.0 3.0 1.9 1.0 1.0 0.9 0.37 YLR421C 1.1 1.3 0.9 1.2 0.9 2.6 1.5 1.5 4.5 3.3 1.2 0.9 1.6 1.6 1.6 1.9 1.2 1.8 2.07 YML118W 1.5 0.5 0.7 2.7 0.7 0.8 1.5 0.9 6.6 1.6 1.3 0.9 1.7 1.0 2.2 1.6 1.5 1.5 0.26 YMR114C 1.2 1.4 0.5 2.4 1.2 1.2 1.7 1.1 2.5 1.7 1.0 0.9 1.1 1.5 1.2 3.0 1.0 1.3 0.62 YMR115W 1.0 0.6 1.3 1.1 0.9 1.5 1.0 1.2 5.8 2.1 1.1 1.0 1.3 1.3 1.2 1.1 1.0 1.2 0.61 YMR258C 0.9 1.4 1.2 1.1 0.7 1.2 1.5 0.9 2.3 1.8 1.4 0.9 1.6 1.0 0.6 1.2 1.1 1.3 0.60 YNL181W 1.2 1.2 0.6 1.2 1.4 1.6 0.9 1.9 5.3 2.8 1.2 0.8 1.8 1.9 1.0 1.0 0.8 1.3 0.86 YNL191W 1.5 5.1 4.7 0.7 0.9 0.6 3.0 1.2 3.9 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3.2 1.0 0.7 1.1 1.4 0.9 1.2 0.4 1.4 0.9 0.55 YAL014C 1.0 1.6 1.4 1.2 0.8 0.6 1.2 1.2 3.1 2.0 1.7 1.2 1.5 1.8 2.3 0.9 1.1 1.1 0.56 YAL017W 0.6 1.4 2.3 1.2 1.0 1.1 1.3 0.6 1.9 1.6 0.7 1.0 2.2 1.1 1.0 1.3 1.0 1.2 0.79 YAL049C 1.0 2.0 1.7 1.0 0.7 1.5 3.4 1.4 3.0 1.4 1.0 1.1 1.6 2.0 1.4 2.9 1.6 1.8 1.13 YBR013C 1.1 2.7 1.8 1.4 0.9 1.8 1.0 1.4 2.2 2.2 1.2 1.2 2.0 2.5 1.1 1.5 1.4 1.1 0.68 YBR051W 1.2 0.8 1.5 0.3 1.1 1.1 1.1 1.5 1.5 0.1 0.7 1.2 1.0 0.8 1.2 1.1 0.8 0.40 YBR063C 0.8 0.8 0.4 0.6 1.2 1.6 1.6 1.3 2.2 1.6 0.6 1.1 1.7 1.7 1.6 1.0 1.2 1.2 0.38 YBR129C 1.1 0.8 0.6 1.0 1.2 1.9 1.0 1.4 2.3 1.4 1.4 1.0 1.3 1.6 0.9 1.7 1.0 1.5 1.25 YBR255W 1.1 1.6 0.4 0.7 1.2 1.0 1.1 1.8 1.8 1.5 1.5 0.7 1.4 1.1 1.0 1.5 1.0 1.0 0.27 YBR281C 0.8 1.1 3.0 0.5 0.8 0.6 1.2 1.8 1.4 1.4 0.5 1.2 0.9 1.0 0.8 0.7 0.8 0.44 YCL044C 0.8 1.4 2.4 0.6 1.1 1.0 1.0 1.0 3.3 4.1 1.1 0.9 1.7 1.0 4.4 0.8 0.9 0.6 0.21 YDL089W 1.1 1.3 1.4 0.9 1.2 2.0 2.0 1.1 2.3 2.5 2.0 0.9 1.9 1.2 1.6 1.3 1.0 1.1 0.45 YDL173W 1.0 1.2 1.0 0.8 1.3 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0.9 0.3 2.7 0.2 0.8 1.5 1.2 0.6 2.1 1.0 1.0 0.29 YLR036C 1.3 0.8 0.7 2.0 1.5 1.3 1.7 1.2 0.4 1.6 0.8 0.7 0.7 1.3 0.6 1.4 1.0 1.4 1.07 YLR112W 1.1 0.9 1.1 1.7 1.3 1.3 1.0 0.7 0.7 0.5 0.5 0.7 0.8 0.4 0.4 1.0 0.8 0.39 YLR125W 1.4 2.0 0.5 3.1 1.8 0.7 1.3 1.2 0.5 1.7 1.1 0.5 0.8 1.3 0.7 1.6 1.2 1.2 0.29 YLR128W 1.3 1.4 0.8 1.8 1.3 1.3 1.1 0.8 1.7 1.4 0.7 1.2 1.4 0.9 1.5 1.2 1.2 0.25 YLR204W 1.1 0.9 0.5 2.1 2.0 1.5 2.0 1.3 1.4 1.6 1.6 0.8 1.1 1.8 1.0 2.5 1.2 1.3 1.26 YLR211C 1.3 1.0 0.8 7.7 1.7 1.2 1.8 1.1 0.9 1.2 0.8 0.7 1.1 1.2 3.6 1.9 1.3 1.3 0.35 YLR257W 1.5 1.0 0.7 2.4 1.4 1.2 0.8 1.3 1.0 1.1 1.2 1.0 1.0 0.9 1.0 1.7 1.8 2.6 5.20 YLR326W 1.2 1.0 1.5 2.2 1.3 0.4 1.2 0.9 0.7 1.5 6.6 0.5 0.4 1.1 0.7 0.9 0.8 1.0 0.33 YLR334C 1.2 1.1 1.1 2.3 1.8 1.0 1.4 0.9 1.0 0.8 0.8 0.8 0.9 2.2 2.5 0.7 0.8 1.0 0.30 YLR408C 1.3 2.3 0.6 2.3 1.4 1.0 1.0 1.4 0.9 1.1 0.7 0.8 1.1 2.1 0.9 1.1 1.2 1.2 0.79 YLR414C 1.5 1.6 1.4 4.8 1.3 0.6 0.7 0.9 0.2 1.2 1.2 0.6 1.0 1.0 2.1 0.9 3.9 3.6 2.21 YLR444C 0.9 0.8 1.7 5.9 0.7 0.7 0.9 0.9 0.2 0.2 1.1 0.6 0.5 1.1 1.3 0.7 0.9 0.9 0.50 YML050W 1.5 1.2 1.3 2.1 0.8 0.5 0.9 1.1 1.3 1.6 1.2 0.8 0.9 1.9 1.0 1.5 0.8 1.1 0.42 YML107C 1.1 0.7 0.4 1.8 2.2 1.1 1.5 1.3 0.6 0.9 0.9 0.7 0.6 1.3 1.0 1.3 1.2 1.5 0.67 YMR031C 0.7 0.8 1.2 2.1 0.6 0.7 0.8 0.9 1.5 1.1 0.8 0.7 1.0 1.0 0.7 1.6 0.9 1.3 1.26 YMR204C 1.1 1.9 1.3 2.3 1.0 0.6 0.7 1.0 1.0 2.2 0.7 0.7 1.1 1.2 1.5 1.1 0.9 1.1 0.31 YMR206W 1.4 1.4 2.3 3.9 1.1 1.0 1.3 0.9 1.0 9.0 1.8 1.0 1.2 1.4 0.3 2.2 1.0 1.2 0.17 YNL010W 1.5 1.0 0.7 1.9 1.0 1.2 1.1 1.8 0.5 0.6 1.1 0.9 0.7 1.2 0.9 1.2 1.0 1.7 4.53 YNL127W 1.1 1.2 0.7 3.6 0.7 1.2 0.8 1.0 2.7 2.2 1.0 1.0 1.7 1.0 1.5 1.4 0.9 1.4 0.36 YNL217W 1.1 1.2 0.5 1.7 2.1 1.5 1.3 1.4 0.3 0.9 0.7 1.0 1.0 0.9 0.5 1.0 1.3 2.1 2.35 YOL118C 2.6 2.2 1.3 2.2 1.5 3.2 1.1 3.2 1.4 0.6 1.7 3.0 1.0 0.5 0.9 1.0 0.24 YOR053W 1.0 1.1 0.5 1.7 1.7 0.9 1.6 0.9 1.3 0.8 1.3 0.6 0.9 1.2 1.0 1.3 1.2 1.2 0.77 YOR352W 1.3 0.9 1.0 2.2 1.6 0.9 1.8 1.1 1.7 2.0 1.1 1.0 1.2 1.3 0.7 2.5 1.3 1.7 0.59 YOR394W 1.2 0.8 2.2 1.6 1.6 1.7 1.8 1.0 1.1 2.3 1.9 0.9 1.3 0.9 0.9 1.7 1.6 1.1 0.51 YPL033C 0.8 1.0 0.9 5.1 1.3 0.7 1.0 0.7 0.4 1.6 0.7 0.6 0.7 1.1 0.8 0.4 0.9 0.8 0.23 YPL066W 0.9 1.0 1.1 2.0 1.3 1.3 1.3 0.9 0.5 0.8 1.0 1.1 0.9 0.7 0.7 1.2 1.3 1.3 0.77 YPR014C 1.0 0.7 1.1 7.9 0.8 0.9 0.8 0.9 0.9 0.5 0.7 0.7 1.0 0.9 0.8 0.9 1.1 0.29 YBR005W 1.9 2.6 1.1 2.9 0.8 0.7 1.2 0.9 0.4 1.3 0.8 1.7 1.9 0.9 1.1 1.7 2.9 4.6 1.00 YFL027C 0.8 0.8 1.1 1.3 1.1 0.3 0.4 1.1 1.8 1.3 1.3 0.6 1.1 0.3 1.4 1.2 5.1 5.2 1.74 YGL080W 1.3 1.5 1.1 1.3 1.5 1.4 1.5 1.2 1.1 1.2 0.8 1.0 0.7 1.6 0.9 1.7 1.3 2.9 1.70 YMR252C 1.1 1.0 1.5 1.3 1.3 1.0 1.3 1.1 0.9 1.0 1.4 0.8 1.1 1.1 1.1 2.1 1.5 2.2 0.86 YOR385W 2.8 1.2 0.2 2.5 1.5 1.0 1.2 1.0 1.5 2.2 1.2 0.6 2.8 0.8 0.8 1.2 4.6 5.9 1.17 YAR033W 1.0 0.8 1.5 1.1 1.1 1.4 2.1 1.2 1.3 1.6 1.5 0.9 1.5 1.3 0.9 2.0 1.1 3.0 1.15 YBR151W 0.8 0.8 1.3 1.2 1.2 1.7 1.3 0.8 0.8 0.9 0.9 0.9 1.1 0.8 1.0 3.0 1.4 2.4 1.83 YHR162W 1.2 1.2 0.9 1.8 1.2 1.3 1.7 1.4 1.0 1.7 1.3 1.2 1.5 2.0 1.1 1.4 1.3 2.7 3.64 YLR165C 1.4 0.8 1.3 1.1 1.1 1.5 1.4 1.1 1.7 1.0 1.4 0.9 1.2 1.4 0.5 1.6 1.1 2.1 0.78 YNL157W 1.4 1.1 0.7 1.5 1.9 0.9 1.3 1.1 1.7 1.4 1.3 0.9 1.6 1.5 1.0 1.0 1.9 2.3 1.41 YOL002C 0.9 0.7 0.5 1.0 2.0 0.9 0.4 0.8 0.1 0.3 0.8 1.1 0.2 0.5 0.6 1.7 1.5 2.1 5.33 YPL233W 1.2 0.9 0.5 1.1 1.4 0.6 1.0 1.0 0.3 0.6 0.9 0.6 1.0 1.0 0.4 1.0 1.9 1.9 0.48 YGR149W 1.4 1.3 1.8 1.9 1.0 1.7 1.8 0.8 0.6 0.6 1.8 1.2 2.6 1.0 2.4 1.3 2.0 1.7 0.71 YNL043C 1.0 4.4 1.6 1.3 0.8 0.6 0.9 0.9 0.4 0.4 0.7 0.9 2.1 1.2 1.6 0.8 2.7 1.6 0.68 YPL067C 1.2 1.6 2.8 1.4 1.0 0.8 1.2 1.2 0.8 0.9 1.4 0.9 0.7 1.5 1.1 2.9 1.7 0.40 YPL170W 1.2 1.3 0.9 1.1 1.9 1.1 0.6 1.1 1.4 1.0 1.1 0.9 1.1 1.4 1.2 1.6 2.2 1.4 1.05 YGL051W 1.1 1.0 1.6 1.7 1.3 1.0 1.3 0.8 1.1 1.8 1.4 1.0 1.5 1.2 0.8 2.6 1.4 1.9 1.06 YIL112W 1.1 1.4 2.8 1.9 0.6 1.3 1.1 0.9 1.3 2.0 1.4 1.2 1.1 1.3 1.8 2.4 1.2 1.3 0.45 YLR052W 1.0 1.5 0.8 1.3 1.0 0.8 1.0 1.2 0.4 1.1 1.1 1.0 0.8 1.2 1.0 2.4 0.7 0.9 0.77 YNL203C 0.9 1.3 0.3 3.2 1.0 1.7 1.6 0.8 0.3 1.1 0.9 1.2 2.7 1.2 5.6 1.3 1.7 0.21 YNR014W 1.0 0.8 1.7 1.2 1.2 0.7 1.7 0.9 0.3 2.3 4.4 0.9 1.5 4.9 1.0 2.4 1.1 1.0 0.31 YAL028W 0.9 0.7 1.1 2.0 1.0 0.6 1.2 0.8 1.6 1.3 1.0 1.0 1.5 1.6 2.2 1.7 1.0 1.0 0.30 YBL095W 0.8 1.4 1.2 1.4 1.1 0.9 1.1 0.9 1.0 0.6 1.2 0.8 1.0 1.0 0.4 2.2 1.3 1.9 0.72 YBR157C 0.7 1.0 0.4 1.4 1.3 1.2 1.6 0.7 0.6 0.3 0.6 0.6 0.5 0.9 0.2 1.9 1.3 0.8 0.69 YDL091C 1.1 1.3 1.8 1.4 0.7 0.8 1.3 1.3 1.6 1.5 1.5 1.0 1.3 1.5 1.9 2.4 1.1 1.6 0.47 YDL216C 1.1 1.1 0.7 2.0 1.6 1.6 1.2 1.6 1.3 1.3 0.7 0.9 1.2 1.1 1.0 1.8 1.0 1.6 0.42 YDR067C 1.3 1.2 0.7 2.7 0.9 1.1 1.3 1.8 1.0 1.3 0.9 0.9 1.2 1.5 1.5 2.4 1.3 1.4 0.76 YDR186C 0.7 0.9 0.7 0.7 1.3 0.7 1.4 1.2 1.2 1.6 0.7 1.1 1.1 0.8 0.8 2.3 1.1 0.9 0.50 YDR196C 0.9 0.9 0.7 1.1 1.0 1.7 1.7 1.5 1.6 1.1 1.3 0.7 1.2 1.0 0.7 2.7 1.2 1.9 1.54 YDR262W 1.3 1.8 0.8 1.2 1.7 1.3 1.7 1.2 0.9 1.7 1.6 0.8 0.9 1.7 1.5 3.8 1.0 1.4 1.11 YDR306C 0.9 1.2 0.7 1.8 1.7 1.2 1.6 1.3 2.0 1.4 2.1 0.9 1.2 1.1 1.2 2.4 1.0 1.5 0.77 YDR319C 1.3 0.9 0.8 1.1 1.2 1.2 1.7 1.3 1.1 1.1 1.3 1.0 1.3 0.8 2.0 2.1 2.2 1.23 YER188W 1.3 0.9 1.2 1.9 0.9 1.5 1.2 0.7 0.4 0.9 1.2 0.9 1.1 1.1 0.3 2.5 1.0 1.1 0.61 YGL004C 0.8 1.4 1.3 1.0 1.0 1.4 2.9 1.4 1.8 2.2 1.0 0.8 1.3 0.9 0.6 2.2 1.1 1.4 0.48 YGR141W 0.8 1.6 1.6 1.7 1.1 1.5 1.5 0.9 0.3 1.0 0.6 0.6 1.0 0.7 2.6 2.1 1.1 1.3 0.65 YHR080C 0.6 1.8 1.9 0.7 0.8 1.8 1.1 1.1 1.9 1.2 0.7 1.2 2.0 0.9 0.9 2.3 1.1 1.3 0.49 YHR097C 1.6 0.7 0.7 0.9 0.8 0.8 0.7 0.4 0.6 0.7 0.8 1.3 0.9 2.7 2.0 1.7 1.4 0.24 YIL077C 0.9 0.8 1.2 1.2 1.3 1.8 1.2 0.9 1.5 1.4 1.3 1.6 1.3 1.3 0.9 2.4 1.3 1.1 0.75 YJL046W 0.9 0.9 0.6 1.8 1.0 0.7 1.5 1.1 1.8 2.7 4.2 0.9 1.3 1.3 1.0 2.5 1.0 1.3 0.68 YLL005C 1.0 1.1 1.1 1.2 1.6 1.9 1.3 1.0 0.4 1.0 0.9 0.8 1.1 1.7 1.0 2.1 1.1 1.2 0.44 YLR151C 1.4 2.0 1.4 1.0 1.0 1.4 1.4 1.5 0.9 1.1 0.5 0.7 1.3 0.7 2.4 1.0 1.4 0.30 YLR271W 1.6 1.2 0.8 1.8 1.4 1.4 1.7 1.5 1.0 1.0 1.3 0.8 1.2 1.2 1.0 3.0 1.5 1.8 0.78 YMR025W 1.2 1.2 0.7 1.5 1.3 1.3 1.4 1.2 1.0 1.6 1.2 0.9 1.2 1.8 1.1 2.4 1.0 1.5 0.42 YMR135C 1.0 1.0 1.1 1.9 1.8 1.0 1.0 1.0 1.1 1.4 1.1 1.0 1.3 1.0 1.4 2.3 1.5 1.3 1.06 YMR210W 1.0 1.1 1.8 1.9 0.6 0.8 1.1 1.1 1.5 2.2 0.8 0.9 1.0 1.0 1.0 2.2 0.8 1.5 0.56 YNR040W 0.8 4.9 0.5 0.9 0.9 1.6 2.1 1.3 1.1 0.8 1.2 0.6 0.8 1.5 0.7 2.1 1.1 1.0 0.30 YPL039W 1.2 0.9 0.6 1.3 1.4 1.5 1.5 1.4 1.1 1.0 0.9 0.9 1.1 1.1 0.6 2.4 1.1 1.1 0.52 YPL099C 1.1 1.9 0.7 2.0 0.9 1.2 1.4 1.4 2.4 1.7 0.8 0.9 1.1 1.3 0.5 2.1 1.0 1.7 0.92 YPL107W 1.2 0.8 1.1 1.3 1.0 1.1 1.2 1.5 1.4 1.3 1.1 0.7 0.8 1.7 0.7 1.8 1.0 1.1 0.59 YPL138C 1.1 1.7 1.1 1.8 0.7 0.5 1.1 1.3 1.1 1.5 0.5 0.9 0.6 1.3 2.7 2.6 0.8 1.1 0.38

TABLE 2 Mitochondria-located protein genes The level of expressed mRNA in the presence of chemical substance/ The level of expressed mRNA in the absence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YJR048W 1.3 0.9 2.2 1.4 0.8 0.5 0.3 0.9 0.5 1.5 1.0 0.8 0.4 2.5 0.6 1.5 1.2 1.2 1.19 YOR226C 1.3 2.2 1.7 1.1 1.3 1.2 1.2 1.2 1.3 5.9 1.5 0.6 0.9 2.7 1.0 0.7 1.0 0.7 0.58 YDL174C 0.9 1.8 0.9 1.3 0.5 1.7 3.6 0.8 0.5 1.7 0.9 2.8 5.9 1.1 0.6 5.1 2.2 4.0 0.63 YBL022C 0.4 0.8 1.2 0.7 1.2 1.2 1.0 0.4 2.8 1.2 1.1 0.9 2.6 1.0 1.5 1.0 0.9 0.7 0.76 YCL057W 0.6 1.5 2.3 0.5 1.1 1.8 1.4 1.8 4.2 2.1 1.6 1.0 3.8 1.0 2.8 1.5 0.9 1.1 0.76 YDR258C 1.6 2.3 2.8 1.4 1.3 2.4 3.9 1.9 4.9 13.3 1.7 1.8 5.2 1.5 0.6 1.0 1.3 1.3 0.87 YGR028W 1.4 3.5 1.0 1.8 0.9 1.5 2.1 1.4 1.7 2.0 1.1 1.5 2.6 1.2 1.0 2.2 1.5 2.6 0.91 YGR244C 1.0 1.2 1.6 1.6 0.8 2.6 3.9 1.8 1.4 1.1 1.8 1.9 2.6 1.2 2.0 2.6 1.9 3.1 1.12 YKL142W 1.8 2.7 3.1 1.4 0.7 3.4 6.9 2.3 5.8 5.9 2.0 1.9 3.3 2.3 1.3 3.3 2.4 3.6 1.68 YNL055C 1.1 1.8 5.5 2.0 0.9 2.6 1.2 0.7 1.1 1.0 1.9 1.7 2.4 0.9 1.1 2.6 1.2 1.7 4.10 YNL071W 0.9 0.9 1.7 1.5 0.6 1.3 1.4 0.9 1.1 1.2 1.6 1.3 2.5 0.8 1.1 1.1 1.0 1.2 1.61 YOR020C 1.4 2.1 1.7 1.7 1.5 2.3 1.7 1.7 5.8 2.6 2.5 0.8 3.0 1.6 1.5 1.4 1.4 1.7 1.66 YOR037W 1.0 1.5 0.6 1.4 1.5 1.6 2.5 1.5 1.3 1.0 1.2 1.2 2.1 1.0 0.9 1.4 1.2 1.6 0.61 YDL198C 1.4 1.0 2.1 1.4 0.7 0.8 1.0 1.1 1.9 2.7 2.5 1.2 2.0 1.7 1.2 1.4 1.5 1.1 1.19 YDR231C 1.1 1.6 1.0 1.5 1.1 2.2 1.7 1.3 1.5 1.4 1.3 1.1 2.4 1.5 1.0 3.0 1.2 1.3 0.92 YER178W 0.8 0.9 3.6 1.0 0.7 2.5 1.6 0.8 1.7 1.3 2.5 1.3 2.4 0.9 1.8 1.0 1.1 0.9 2.18 YFL016C 0.8 1.0 1.6 0.9 1.3 1.3 1.4 0.7 6.4 2.9 1.2 1.0 2.8 0.8 0.8 0.6 1.2 0.9 1.25 YGR008C 2.1 3.0 1.7 3.2 0.9 2.9 3.7 1.9 3.1 2.4 2.6 2.0 3.4 1.3 1.5 2.3 1.7 4.2 3.03 YIL155C 1.0 0.7 1.4 3.7 1.3 1.4 2.2 1.0 2.5 2.9 1.3 1.4 2.0 1.3 1.4 3.8 1.1 1.4 0.51 YJL102W 1.1 0.7 0.4 0.8 1.3 1.6 0.6 0.9 3.1 2.2 0.7 0.8 2.6 1.5 1.5 0.6 1.0 1.1 0.22 YJR045C 0.5 1.9 3.9 0.5 1.2 1.0 0.8 3.2 3.0 1.4 1.0 2.3 0.5 2.3 0.8 0.7 0.9 3.78 YLR259C 0.7 1.0 3.1 1.6 1.1 0.9 1.8 0.8 1.8 2.6 3.0 0.7 2.5 0.8 2.1 1.3 0.8 1.0 2.09 YLR348C 1.1 4.5 1.2 1.2 0.9 1.9 0.9 0.9 2.1 1.3 1.3 0.9 1.9 1.0 2.4 1.1 1.1 1.0 0.64 YML054C 1.5 1.8 1.3 3.4 1.3 1.8 1.2 1.5 4.1 1.8 1.4 1.8 2.8 2.1 1.1 7.8 1.1 1.6 0.25 YMR089C 0.8 1.1 0.9 0.9 0.8 1.2 1.2 1.3 5.6 2.5 1.3 0.8 2.3 0.9 1.8 1.1 0.9 1.1 0.69 YMR152W 0.9 1.1 1.8 0.9 0.8 7.5 0.8 0.8 2.7 1.3 1.2 1.3 1.9 1.1 0.6 1.0 1.5 0.9 0.71 YNL104C 1.1 1.3 3.0 0.9 0.8 0.8 0.6 0.9 1.1 2.0 2.1 1.1 2.1 0.9 2.5 1.5 0.9 0.9 1.69 YOR130C 0.8 1.7 1.4 1.0 1.8 1.6 1.3 0.8 2.0 1.7 0.6 0.9 2.1 1.3 1.0 0.8 1.5 1.1 0.51 YPR024W 0.7 1.0 1.3 1.0 1.3 1.0 1.4 0.7 3.0 1.7 0.9 0.8 2.5 0.7 1.0 1.6 1.1 0.8 0.84 YPR067W 1.6 1.2 1.7 0.9 1.3 1.3 1.5 1.4 3.5 3.4 1.8 1.0 3.0 1.6 1.3 0.8 1.0 1.0 0.66 YBR029C 0.7 0.2 1.8 1.0 1.4 0.8 0.4 0.7 2.0 1.1 0.7 1.3 1.7 0.9 3.5 0.9 0.6 0.8 1.56 YCL009C 0.6 0.9 2.0 0.5 0.7 1.8 1.3 1.1 0.9 1.6 1.5 1.7 1.6 0.7 6.5 0.9 1.1 0.8 0.68 YER026C 0.8 0.6 3.3 1.0 1.2 2.5 1.6 0.8 0.9 1.5 0.9 1.7 1.9 1.1 4.0 1.4 1.7 3.2 4.48 YLR109W 0.8 2.9 6.0 0.9 1.3 2.1 2.6 0.9 2.4 2.7 1.5 1.6 3.2 2.3 3.9 1.8 1.1 1.2 3.86 YMR189W 0.7 0.8 1.9 2.8 0.4 1.9 0.8 0.4 0.7 0.9 8.2 0.6 0.9 1.6 5.6 0.9 1.0 0.8 0.88 YNL169C 0.7 1.4 1.4 1.2 0.7 1.4 0.7 0.8 1.1 1.1 0.8 1.0 1.7 0.9 3.4 0.8 1.1 1.3 1.05 YER069W 1.3 0.8 3.3 1.4 1.5 1.3 1.0 1.5 0.8 10.4 1.5 0.8 1.4 1.3 2.4 1.1 1.1 0.9 0.25 YIL022W 0.8 0.7 1.1 1.6 0.8 1.2 0.7 0.8 1.1 1.3 1.0 0.9 1.2 0.6 2.9 1.1 0.8 0.7 0.52 YBR146W 0.9 0.8 0.7 1.5 1.3 2.6 1.5 1.0 0.9 1.1 1.2 1.0 1.7 1.2 1.0 2.9 1.0 1.2 1.61 YDR019C 1.4 0.5 1.7 4.0 0.9 4.8 1.4 0.7 0.4 0.7 1.8 0.7 1.0 1.6 1.8 1.8 1.2 1.6 2.48 YGR207C 1.5 1.1 1.0 1.1 1.5 2.8 1.7 1.9 2.1 2.6 1.4 1.1 1.0 2.2 0.6 1.8 1.2 1.8 1.49 YMR072W 1.1 1.0 1.4 1.0 1.7 2.4 1.4 1.0 3.0 1.2 1.9 0.8 2.1 1.2 0.8 1.7 0.9 1.9 2.06 YNL037C 1.4 1.8 1.7 1.1 1.7 2.8 2.8 1.0 0.6 3.2 1.4 1.3 1.9 1.3 0.9 1.4 0.9 1.3 2.05 YOR136W 1.0 0.9 3.5 1.0 1.5 3.9 3.2 1.1 0.3 3.4 1.4 1.2 1.5 0.9 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0.7 1.2 1.1 0.9 1.0 1.3 1.3 0.8 1.2 0.8 0.7 2.0 1.1 1.3 1.06 YBR044C 0.8 1.4 0.7 1.9 1.4 1.0 1.5 1.1 0.8 1.2 1.1 0.8 1.2 0.9 0.9 1.4 0.9 1.3 0.57 YBR091C 1.1 1.0 0.6 3.0 1.1 0.7 1.0 1.5 0.7 1.6 0.7 0.8 1.2 1.7 0.9 0.9 1.0 1.0 0.87 YBR185C 1.2 1.0 1.3 2.0 0.8 1.2 1.2 1.1 0.9 1.6 1.2 0.7 1.0 1.7 1.0 1.7 0.8 1.3 0.89 YBR282W 1.0 1.0 0.5 2.3 1.0 1.4 1.2 1.4 1.0 0.9 0.9 0.8 1.3 1.4 1.1 1.5 0.9 1.2 1.36 YDR347W 1.1 0.8 0.9 3.5 0.8 1.2 1.2 1.2 0.8 1.6 0.8 0.8 1.3 1.5 1.0 1.7 0.9 1.2 1.33 YEL039C 1.1 0.7 1.3 5.1 0.9 1.5 0.6 1.1 1.2 1.2 1.7 0.6 0.5 1.4 0.4 3.5 0.7 1.1 1.59 YGR076C 1.3 1.6 0.6 2.3 0.9 1.2 1.7 1.9 1.2 1.8 1.7 1.0 1.4 2.3 0.5 2.3 0.9 1.5 0.97 YGR174C 1.1 1.6 0.6 2.4 1.0 1.4 1.0 1.6 1.8 0.7 1.3 0.9 1.5 1.6 0.7 3.2 1.3 2.3 1.05 YKL003C 1.1 0.7 0.8 1.8 1.0 1.0 1.4 1.2 1.5 2.2 1.7 0.7 1.3 2.0 1.0 2.3 1.0 1.2 0.90 YKL016C 1.5 1.3 0.7 1.7 1.5 0.8 1.5 1.6 1.3 1.8 1.3 1.0 1.3 1.6 0.7 1.8 1.0 1.7 2.08 YKL170W 1.0 0.8 0.5 1.9 1.3 1.5 1.5 1.2 0.9 1.1 0.7 0.8 0.9 1.3 0.8 2.1 1.1 1.4 1.27 YKL194C 0.9 0.7 0.8 1.6 1.8 1.4 2.1 1.1 1.3 1.4 1.6 0.6 1.1 1.4 0.8 1.2 1.1 1.1 0.52 YLR395C 1.8 1.3 2.2 1.9 0.7 0.4 1.0 1.0 0.9 1.5 0.6 0.5 1.7 0.4 1.2 1.2 2.3 1.76 YML120C 1.1 1.2 1.9 1.9 0.6 0.6 0.8 0.9 1.3 1.5 1.3 0.9 1.2 0.8 0.5 1.5 1.0 1.6 0.74 YOR100C 1.3 1.4 1.6 1.7 1.0 1.2 1.6 1.0 2.0 2.6 1.4 0.8 1.0 1.4 4.3 2.8 0.9 0.8 0.32 YOR150W 1.7 1.2 1.0 1.9 0.8 0.9 1.2 1.1 0.8 1.8 1.0 0.8 1.0 1.6 0.8 1.6 0.9 1.3 1.11 YOR187W 1.0 0.5 1.9 2.0 0.6 1.7 1.5 0.7 0.6 0.8 1.4 0.8 0.7 0.6 1.3 1.6 0.8 1.3 3.12 YJL166W 2.1 1.5 1.6 1.3 1.6 0.7 0.8 1.4 1.3 1.2 1.4 0.7 0.8 1.9 0.5 2.3 1.7 4.0 2.31 YMR035W 1.2 1.7 1.5 1.7 0.8 1.5 2.3 1.4 1.7 1.6 1.5 0.5 1.4 1.3 1.1 1.5 2.2 2.4 0.96 YBL038W 1.0 0.9 0.5 1.8 0.9 0.7 8.0 1.6 1.4 1.5 0.7 0.7 1.0 2.3 0.7 1.8 1.2 1.9 1.56 YDR377W 1.3 1.1 1.3 1.4 1.9 1.3 1.1 1.3 1.0 0.9 1.4 0.9 0.7 1.4 0.6 1.8 1.2 2.5 3.00 YGL187C 1.5 0.8 1.6 1.8 1.3 1.1 0.6 0.7 0.6 0.6 0.7 0.8 0.7 0.9 0.3 1.4 0.9 2.4 2.73 YCR046C 1.0 1.2 1.2 1.6 1.0 0.8 1.2 0.9 1.9 1.4 1.5 1.1 1.5 1.3 1.4 2.8 1.3 1.0 0.63 YML129C 1.1 0.9 0.9 1.2 1.7 1.7 1.8 1.2 1.4 2.2 1.2 0.8 1.0 1.4 1.1 2.9 1.3 1.3 1.04 YOL096C 1.1 1.0 1.2 1.6 1.2 1.3 1.7 1.0 1.3 1.4 1.2 1.2 1.4 1.4 1.0 2.3 1.2 1.2 0.64 YBR122C 0.9 0.9 0.3 1.1 1.5 1.1 2.0 1.3 1.1 1.4 1.2 0.7 0.8 1.2 0.7 1.9 0.9 1.5 1.53 YBR251W 1.0 0.9 1.0 1.2 1.3 2.0 1.4 1.3 0.5 1.1 1.5 1.1 1.0 1.6 0.8 3.0 0.9 1.4 1.13 YCR083W 1.1 2.8 1.5 1.8 1.6 2.4 1.8 1.5 1.8 1.8 1.8 1.1 1.8 2.4 1.0 3.1 1.3 1.3 0.98 YDL067C 1.8 1.0 1.6 1.3 2.0 0.9 0.8 1.1 0.9 0.9 1.4 1.0 0.6 1.4 0.7 1.8 1.2 1.7 1.85 YDR079W 1.3 1.1 0.8 1.1 1.2 1.7 1.3 2.6 0.9 0.8 1.3 1.1 1.3 1.5 0.6 2.6 1.1 1.3 1.06 YGR062C 0.9 1.0 0.7 1.4 0.7 0.9 1.3 0.8 1.0 1.4 1.6 1.0 1.5 1.2 0.5 1.8 0.9 1.1 0.54 YJL096W 1.0 1.0 0.8 1.3 1.9 1.0 1.7 1.3 1.0 1.4 1.2 1.0 0.7 2.1 1.0 2.2 1.1 1.2 1.21 YJL180C 0.9 1.6 1.1 1.3 1.5 1.3 1.6 1.0 1.4 1.4 1.4 0.8 1.2 1.4 0.6 2.0 0.9 1.4 1.08 YLR295C 1.4 1.1 1.1 1.7 2.2 1.1 1.1 1.2 1.4 1.2 1.3 0.5 0.8 1.2 0.5 2.4 0.9 1.5 1.07 YMR023C 1.4 1.3 0.5 1.9 1.7 1.1 1.9 1.4 1.5 2.6 0.8 0.7 1.1 1.6 0.7 2.1 1.1 1.4 0.48 YMR267W 0.8 1.8 0.7 0.9 1.0 1.4 1.2 1.5 0.4 0.8 1.0 0.8 0.7 1.0 0.9 2.6 0.9 1.3 0.94 YNL073W 0.8 1.4 0.9 1.7 0.6 0.5 1.1 1.0 0.9 1.8 1.1 0.7 1.2 0.7 0.7 1.8 0.8 1.0 0.52 YOR316C 0.7 2.5 1.5 1.5 1.0 0.9 1.4 0.8 1.6 2.0 2.4 1.1 1.6 1.0 1.5 2.2 0.8 1.0 0.93 YPL040C 1.1 1.0 0.8 1.7 0.8 1.1 0.8 1.1 0.2 1.2 0.9 0.9 1.0 1.1 1.1 2.7 0.8 1.1 0.33 YPL134C 1.5 1.0 1.6 1.6 1.4 1.2 1.2 1.3 0.6 0.8 1.7 0.8 1.0 1.4 1.1 3.3 1.3 1.3 0.70

TABLE 3 DNA repair protein genes The level of expressed mRNA in the presence of chemical substance/ The level of expressed mRNA in the absence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YFL014W 3.4 5.1 5.7 11.0 1.0 9.3 5.5 3.4 13.1 5.8 5.0 4.3 15.2 7.3 6.3 14.2 1.5 8.8 2.14 YGL163C 0.9 0.8 0.6 4.3 1.5 0.9 1.0 1.4 5.8 2.3 0.4 0.9 3.1 1.6 1.8 1.0 0.9 0.8 0.26 YKL145W 0.8 1.4 1.2 1.0 1.4 2.1 1.6 1.5 3.5 2.7 1.8 1.3 2.7 1.0 1.3 1.2 1.1 1.5 2.29 YIL153W 0.8 1.4 1.3 2.9 1.0 0.9 1.6 0.5 4.3 1.1 1.0 1.0 1.2 1.0 2.8 1.3 0.9 0.7 0.32 YIR002C 0.8 1.1 0.5 0.6 1.2 2.2 1.3 1.2 1.7 1.4 0.8 1.3 1.2 1.1 1.1 1.4 1.1 1.2 0.58 YAL015C 1.2 1.1 1.7 1.9 1.1 0.7 1.2 1.1 4.0 2.7 1.4 1.0 1.2 1.6 0.7 2.0 1.1 1.2 0.61 YBR073W 0.7 1.0 0.9 0.7 1.2 0.7 0.6 1.1 2.5 1.8 0.5 0.9 1.4 1.0 1.3 0.8 0.7 0.8 0.63 YDL200C 1.4 2.0 1.2 1.8 1.1 0.6 1.7 1.5 2.4 1.8 1.2 1.1 1.1 1.8 0.7 1.8 0.9 1.6 0.79 YGL058W 1.1 1.1 0.6 0.7 1.0 1.0 0.0 1.3 3.7 1.8 0.8 1.3 1.0 1.3 1.3 0.6 1.1 0.7 1.07 YIL143C 0.9 0.8 1.1 0.9 0.8 1.4 0.8 0.9 7.1 3.5 1.5 0.9 1.7 1.0 1.3 1.1 0.9 0.9 0.56 YML032C 0.8 0.9 1.1 0.7 1.0 0.9 0.8 0.9 3.0 1.1 1.0 0.9 1.8 1.0 1.7 1.2 1.0 1.0 0.66 YNL250W 0.9 2.2 0.8 1.2 0.8 0.8 1.2 1.3 4.2 2.3 1.0 1.4 1.3 1.6 1.3 1.4 1.0 1.0 0.31 YOR386W 1.0 0.8 1.3 1.5 1.2 3.3 1.8 1.0 4.1 3.0 1.4 1.2 2.4 0.9 1.3 1.2 2.1 1.7 0.46 YBL019W 0.9 9.1 0.7 1.2 1.0 1.0 1.2 1.2 2.6 1.4 1.0 0.8 0.9 1.1 0.6 1.9 0.8 1.1 0.38 YDR369C 1.1 1.1 2.4 1.1 1.0 0.6 0.4 1.0 2.4 1.8 1.1 0.9 0.1 0.7 1.2 0.6 0.8 0.7 1.88 YEL037C 0.9 2.0 0.9 1.0 0.5 0.6 0.8 0.8 2.6 1.2 1.0 1.1 2.0 1.0 1.6 0.5 1.0 0.8 0.82 YER162C 1.0 1.2 1.0 1.1 0.9 0.7 0.5 0.9 2.8 1.6 0.5 0.4 0.8 0.8 1.0 1.0 1.2 0.9 0.45 YGR258C 0.7 0.9 0.7 0.7 1.5 2.2 1.5 0.8 2.5 1.5 0.3 0.9 1.9 1.2 1.1 1.2 1.0 0.9 0.37 YJR052W 1.1 1.0 1.1 1.0 1.0 1.4 1.2 1.7 4.5 2.3 1.1 1.1 1.8 1.4 1.4 1.4 1.0 1.3 0.36 YOR005C 1.2 1.8 1.0 0.8 1.3 1.3 1.4 1.3 2.4 1.5 1.2 0.9 2.1 1.2 0.8 1.4 1.1 1.0 0.29 YPL022W 0.7 0.8 0.7 1.2 0.8 5.2 0.8 1.0 2.1 1.6 0.8 0.7 1.4 0.9 0.9 1.0 0.9 0.9 0.72 YPL164C 1.1 0.7 1.1 1.0 1.2 1.7 0.9 1.0 2.1 2.0 1.1 0.9 1.0 0.9 1.3 1.4 1.0 1.0 0.25 YPL194W 0.9 1.4 0.4 1.1 1.3 1.1 1.5 1.3 9.6 3.1 0.9 0.9 1.4 1.1 1.4 0.9 1.0 0.8 0.22 YPR025C 1.1 0.8 0.6 0.6 1.6 0.9 1.4 1.3 1.9 1.7 0.9 0.7 1.1 1.3 1.1 1.3 1.1 1.5 0.87 YGR180C 3.1 1.1 1.9 1.0 2.0 0.6 0.5 1.0 1.4 1.5 1.0 0.9 0.9 0.9 1.3 1.2 1.0 1.9 3.90 YEL019C 1.1 1.6 0.3 0.7 0.9 1.5 1.2 0.9 0.7 0.7 1.2 1.0 1.0 1.7 1.5 0.3 0.8 0.9 0.27 YLR288C 1.2 0.8 1.6 1.8 1.7 1.2 1.3 1.5 0.8 1.3 1.4 0.6 0.7 1.2 0.9 1.5 1.2 1.3 0.31 YMR284W 1.1 1.0 0.5 2.0 0.8 0.8 0.8 1.1 1.6 1.8 1.1 0.6 1.0 1.2 0.7 1.3 1.1 1.3 0.54 YMR035W 1.2 1.7 1.5 1.7 0.8 1.5 2.3 1.4 1.7 1.6 1.5 0.5 1.4 1.3 1.1 1.5 2.2 2.4 0.96 YOL043C 1.1 0.9 0.8 1.7 1.2 0.8 1.0 0.9 1.0 1.8 1.2 0.8 0.9 1.5 0.6 2.5 1.0 1.0 0.38 YGR231C 1.0 1.2 0.7 1.0 1.3 1.9 2.1 1.1 3.2 2.3 1.6 1.3 3.9 2.2 1.3 2.5 1.0 1.5 1.74 YHR164C 0.9 1.3 0.9 0.7 0.9 1.4 0.8 1.1 1.3 3.1 0.6 1.2 2.0 1.3 2.2 1.1 0.8 1.0 0.44 YJR046W 1.0 1.2 1.2 1.5 0.8 2.0 0.9 0.9 6.0 2.4 0.6 0.9 3.0 1.0 1.1 0.8 0.7 0.7 0.45 YLR103C 0.8 1.5 1.1 0.4 1.0 1.1 1.3 1.4 0.8 0.5 0.9 1.6 3.0 1.0 0.8 1.5 1.1 1.4 1.32 YMR072W 1.1 1.0 1.4 1.0 1.7 1.6 1.4 1.0 3.0 1.2 1.9 0.8 2.1 1.2 0.8 1.7 0.9 1.9 2.06 YDR054C 1.3 1.0 0.7 1.4 0.7 1.9 1.1 1.5 2.9 3.2 1.9 1.0 2.5 1.1 1.6 1.4 0.8 1.4 1.18 YAR007C 0.7 1.9 0.8 0.5 1.5 1.6 0.8 1.1 4.1 1.7 0.9 0.9 1.7 1.4 1.2 0.9 0.8 1.0 1.03 YGL058W 1.1 1.1 0.6 0.7 1.0 1.5 0.0 1.3 3.7 1.8 0.8 1.3 1.0 1.3 1.3 0.6 1.1 0.7 1.07 YIL036W 0.9 1.3 1.3 1.8 0.9 1.8 1.4 1.1 3.6 2.7 1.2 1.2 1.9 1.1 0.8 1.3 1.1 1.3 0.66 YNL213C 1.7 11.6 0.9 1.5 1.3 1.7 1.4 1.8 3.0 1.5 1.5 0.8 0.9 1.8 1.0 1.7 0.9 1.2 0.70 YNL312W 0.9 1.0 1.6 0.7 1.4 1.7 0.5 1.2 3.7 2.5 1.4 0.9 0.7 1.1 0.8 0.8 1.2 1.1 2.05 YNL261W 1.0 1.3 0.6 1.3 0.7 1.3 1.0 1.1 2.3 1.5 0.8 0.8 0.8 1.4 0.7 1.1 0.8 1.0 0.91 YGR180C 3.1 1.1 1.9 1.0 2.0 1.0 0.5 1.0 1.4 1.5 1.0 0.9 0.9 0.9 1.3 1.2 1.0 1.9 3.90 YJL026W 2.5 2.4 2.9 1.0 1.7 1.0 0.5 1.2 1.0 1.1 1.3 1.0 1.2 1.0 1.1 1.6 1.4 2.1 3.74 YDL017W 0.8 2.3 1.2 1.3 1.2 1.1 1.1 1.2 0.8 1.8 0.8 0.8 0.9 1.3 1.3 1.0 0.8 1.0 0.38 YML058W 1.9 1.2 5.8 1.9 0.6 1.3 0.6 0.7 1.1 1.2 3.3 0.9 1.4 1.1 2.5 1.3 1.3 1.5 2.14 YLR233C 1.1 0.9 2.0 2.0 1.2 0.8 0.8 1.1 0.6 0.5 0.8 0.9 1.0 1.1 1.1 1.1 1.0 1.2 0.43 YMR284W 1.1 1.0 0.5 2.0 0.8 1.2 0.8 1.1 1.6 1.8 1.1 0.6 1.0 1.2 0.7 1.3 1.1 1.3 0.54 YGL163C 0.9 0.8 0.6 4.3 1.5 0.9 1.0 1.4 5.8 2.3 0.4 0.9 3.1 1.6 1.8 1.0 0.9 0.8 0.26 YGL127C 1.0 1.9 1.3 1.7 1.3 0.6 1.0 0.9 1.2 1.5 1.0 1.4 1.7 1.0 1.5 1.3 1.0 1.2 0.54 YMR072W 1.1 1.0 1.4 1.0 1.7 2.4 1.4 1.0 3.0 1.2 1.9 0.8 2.1 1.2 0.8 1.7 0.9 1.9 2.06 YGL249W 1.4 0.8 0.5 0.8 1.1 2.5 1.2 0.9 0.3 2.4 0.6 0.8 0.8 1.9 0.7 1.4 1.0 1.0 0.20 YBR272C 0.8 1.8 1.3 1.0 1.1 1.9 1.1 1.7 2.7 1.1 0.5 1.3 1.0 0.5 1.7 1.1 1.2 0.52 YDL059C 2.6 5.1 1.4 1.7 1.2 1.2 1.1 1.2 10.5 7.8 2.0 1.3 1.7 4.7 0.7 1.5 0.8 0.9 0.63 YAR007C 0.7 1.9 0.8 0.5 1.5 0.6 0.8 1.1 4.1 1.7 0.9 0.9 1.7 1.4 1.2 0.9 0.8 1.0 1.03 YBR073W 0.7 1.0 0.9 0.7 1.2 0.7 0.6 1.1 2.5 1.8 0.5 0.9 1.4 1.0 1.3 0.8 0.7 0.8 0.63 YML032C 0.8 0.9 1.1 0.7 1.0 0.9 0.8 0.9 3.0 1.1 1.0 0.9 1.8 1.0 1.7 1.2 1.0 1.0 0.66 YNL250W 0.9 2.2 0.8 1.2 0.8 0.8 1.2 1.3 4.2 2.3 1.0 1.4 1.3 1.6 1.3 1.4 1.0 1.0 0.31 YCR014C 0.8 1.0 0.8 0.6 1.2 1.1 1.1 1.0 2.4 1.0 0.8 0.7 1.2 1.0 0.7 1.5 1.0 0.9 0.34 YDR369C 1.1 1.1 2.4 1.1 1.0 0.6 0.4 1.0 2.4 1.8 1.1 0.9 0.1 0.7 1.2 0.6 0.8 0.7 1.88 YIL072W 0.8 3.1 1.1 2.6 1.5 1.2 1.7 1.4 2.9 2.1 1.8 1.1 1.4 2.0 1.4 1.4 1.0 1.1 0.23 YOR005C 1.2 1.8 1.0 0.8 1.3 1.3 1.4 1.3 2.4 1.5 1.2 0.9 2.1 1.2 0.8 1.4 1.1 1.0 0.29 YPL164C 1.1 0.7 1.1 1.0 1.2 1.7 0.9 1.0 2.1 2.0 1.1 0.9 1.0 0.9 1.3 1.4 1.0 1.0 0.25 YPL194W 0.9 1.4 0.4 1.1 1.3 1.1 1.5 1.3 9.6 3.1 0.9 0.9 1.4 1.1 1.4 0.9 1.0 0.8 0.22 YGR180C 3.1 1.1 1.9 1.0 2.0 0.6 0.5 1.0 1.4 1.5 1.0 0.9 0.9 0.9 1.3 1.2 1.0 1.9 3.90 YEL019C 1.1 1.6 0.3 0.7 0.9 1.5 1.2 0.9 0.7 0.7 1.2 1.0 1.0 1.7 1.5 0.3 0.8 0.9 0.27 YML058W 1.9 1.2 5.8 1.9 0.6 0.6 0.6 0.7 1.1 1.2 3.3 0.9 1.4 1.1 2.5 1.3 1.3 1.5 2.14 YLR288C 1.2 0.8 1.6 1.8 1.7 1.2 1.3 1.5 0.8 1.3 1.4 0.6 0.7 1.2 0.9 1.5 1.2 1.3 0.31 YMR284W 1.1 1.0 0.5 2.0 0.8 0.8 0.8 1.1 1.6 1.8 1.1 0.6 1.0 1.2 0.7 1.3 1.1 1.3 0.54 YMR096W 1.7 1.7 1.1 0.8 1.0 2.2 1.9 2.0 3.3 3.7 1.5 1.4 8.4 4.7 28.9 2.2 2.2 1.0 0.62 YGL091C 2.0 1.8 1.0 1.7 0.8 1.6 1.3 1.8 10.8 6.0 2.1 1.2 2.5 3.1 0.7 1.0 1.4 1.8 0.96

TABLE 4 Energy system protein genes The level of expressed mRNA in the presence of chemical substance/ The level of expressed mRNA in the absence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YCR107W 12.1 2.6 1.8 1.6 0.7 1.5 1.5 15.6 196.6 34.0 23.0 0.9 4.0 8.3 4.8 3.1 1.3 1.1 0.59 YDL243C 14.5 2.7 2.4 1.0 1.1 2.2 1.6 11.8 64.2 29.6 19.6 1.1 4.1 12.0 4.2 3.0 1.8 1.5 0.76 YFL056C 19.0 2.3 2.3 1.5 0.9 0.6 1.4 18.5 162.3 31.3 68.3 1.0 4.7 7.8 5.0 3.4 1.0 1.1 0.55 YFL057C 20.9 5.9 1.5 1.8 0.9 1.2 1.8 18.0 51.8 46.1 27.7 1.0 4.1 23.4 3.1 3.9 1.6 1.3 0.71 YJR155W 7.6 3.7 1.4 2.5 0.7 1.4 1.7 10.6 38.2 18.8 15.4 1.0 5.7 9.4 2.6 5.6 1.3 1.4 0.64 YNL331C 8.6 3.6 1.3 1.0 1.6 1.8 1.9 13.1 42.6 36.3 21.8 0.9 3.1 7.5 2.3 4.0 1.7 1.3 0.58 YOL165C 10.1 4.5 1.8 0.9 0.9 1.7 1.4 17.8 46.9 23.3 17.6 0.8 3.7 9.1 3.0 1.8 1.6 1.0 0.69 YPL171C 15.2 4.1 3.5 2.2 1.1 1.3 1.7 20.5 60.0 50.6 37.0 1.4 2.4 9.3 1.4 1.2 2.4 1.5 0.47 YDL021W 5.1 1.7 2.4 3.7 1.7 6.5 5.9 2.7 2.5 7.4 4.7 2.4 5.3 3.7 0.7 7.3 1.9 3.2 0.47 YGR043C 2.6 3.7 3.2 7.9 0.9 16.3 6.5 2.6 10.9 8.4 3.6 3.3 6.9 4.1 3.0 13.7 1.6 4.8 0.66 YHR179W 3.3 2.3 2.6 0.7 1.2 3.7 1.9 3.3 3.6 5.8 2.0 2.2 2.6 5.8 2.7 1.0 1.9 1.6 2.69 YJR048W 1.3 0.9 2.2 1.4 0.8 0.5 0.3 0.9 0.5 1.5 1.0 0.8 0.4 2.5 0.6 1.5 1.2 1.2 1.19 YKR097W 1.6 2.4 1.3 3.3 1.1 1.7 3.7 2.5 1.9 3.3 0.8 1.8 17.5 2.1 2.5 2.2 1.1 1.5 0.16 YML087C 1.8 1.6 0.8 2.5 0.9 0.9 1.1 1.3 1.9 4.9 1.6 0.8 1.5 2.1 0.3 2.0 0.7 0.8 0.52 YPL088W 3.3 1.3 0.6 2.5 1.5 7.1 3.7 1.9 0.6 2.8 1.1 3.6 4.8 1.6 3.2 4.3 9.1 8.3 0.69 YDL174C 0.9 1.8 0.9 1.3 0.5 1.7 3.6 0.8 0.5 1.7 0.9 2.8 5.9 1.1 0.6 5.1 2.2 4.0 0.63 YCR012W 1.2 1.5 5.1 1.2 1.1 2.5 1.4 0.8 1.4 1.5 1.8 1.2 4.1 0.9 1.4 1.4 0.8 1.3 4.48 YFR053C 1.8 1.4 3.0 2.2 0.9 3.2 2.1 2.8 0.6 1.1 1.5 1.7 3.0 0.6 0.6 3.0 1.4 2.2 4.17 YGL062W 0.6 1.3 1.1 0.6 0.9 1.0 1.3 0.8 1.6 2.5 0.7 1.6 4.5 1.2 2.7 1.5 1.1 0.9 0.77 YGR192C 1.4 1.0 3.8 1.0 1.1 1.7 1.7 1.1 0.9 1.3 2.3 2.2 3.4 1.0 1.9 1.1 1.1 1.3 7.49 YGR244C 1.0 1.2 1.6 1.6 0.8 2.6 3.9 1.8 1.4 1.1 1.8 1.9 2.6 1.2 2.0 2.6 1.9 3.1 1.12 YGR254W 1.2 1.3 3.8 1.3 1.2 1.9 1.5 1.4 0.8 1.2 1.3 1.7 3.1 0.6 2.4 1.4 1.3 1.2 7.01 YIL160C 0.8 2.4 2.3 3.5 1.0 1.6 1.1 1.2 3.2 3.8 2.4 1.0 2.3 1.5 5.6 8.8 2.4 3.0 0.27 YJL052W 1.6 0.9 4.0 1.8 0.7 2.4 2.1 1.5 1.6 2.0 4.3 2.4 5.6 1.3 2.3 2.3 1.2 1.9 6.19 YJR009C 1.1 1.7 5.6 1.0 1.2 1.6 1.6 1.1 1.1 1.3 1.1 1.5 2.7 1.0 2.1 1.5 1.1 1.3 5.86 YLR345W 1.4 1.4 1.4 1.2 1.2 1.6 1.2 1.4 4.5 4.0 2.5 1.6 3.5 1.5 1.0 1.2 1.2 1.4 2.65 YMR118C 1.3 2.9 1.4 1.6 1.2 2.0 1.0 1.0 9.3 1.4 0.7 0.8 4.2 0.9 0.9 8.1 0.8 1.0 0.38 YNL071W 0.9 0.9 1.7 1.5 0.6 1.3 1.4 0.9 1.1 1.2 1.6 1.3 2.5 0.8 1.1 1.1 1.0 1.2 1.61 YNL241C 1.3 2.5 4.3 1.0 0.8 0.9 3.2 0.9 3.4 7.4 3.0 2.0 4.9 1.1 7.0 2.8 1.0 1.0 0.68 YPL240C 0.7 1.4 2.4 0.9 1.3 1.2 1.4 1.2 3.5 2.6 1.0 0.8 2.9 0.7 1.2 0.7 0.8 1.0 4.83 YAL060W 1.1 1.8 3.2 2.7 1.2 4.2 3.3 0.9 0.6 2.5 2.4 0.8 2.2 0.9 0.9 3.2 1.1 1.8 2.39 YCL040W 0.9 5.6 10.1 2.0 0.5 3.5 2.9 0.7 0.9 3.0 8.2 2.3 5.6 0.7 3.4 3.1 1.4 1.7 1.98 YDR001C 1.0 2.2 2.6 1.0 1.1 2.2 1.5 0.9 2.2 3.0 0.7 1.1 2.8 1.0 4.4 1.9 1.1 1.6 0.75 YDR231C 1.1 1.6 1.0 1.5 1.1 2.2 1.7 1.3 1.5 1.4 1.3 1.1 2.4 1.5 1.0 3.0 1.2 1.3 0.92 YER178W 0.8 0.9 3.6 1.0 0.7 2.5 1.6 0.8 1.7 1.3 2.5 1.3 2.4 0.9 1.8 1.0 1.1 0.9 2.18 YGR008C 2.4 3.0 1.7 3.2 0.9 2.9 3.7 1.9 3.1 2.4 2.6 2.0 3.4 1.3 1.5 2.3 1.7 4.2 3.03 YGR256W 1.2 1.5 2.3 0.8 0.9 6.2 1.4 2.2 3.4 2.5 2.7 1.5 3.9 1.1 2.7 5.3 1.1 0.8 0.94 YHL008C 0.9 0.5 1.0 1.6 0.8 0.8 0.7 0.9 1.6 1.7 1.4 0.8 1.8 1.0 1.8 0.9 0.8 0.9 0.40 YHR174W 1.1 1.4 3.3 1.2 1.3 1.5 1.6 1.2 1.0 1.5 1.4 1.5 3.6 0.6 2.0 1.1 1.0 1.2 7.34 YIL045W 1.7 1.4 1.9 2.2 1.3 1.7 1.6 1.1 2.1 3.2 1.2 1.5 2.0 1.6 0.6 2.9 1.1 1.8 0.37 YKL035W 1.0 0.9 4.8 1.2 0.8 1.2 0.6 1.0 0.8 1.2 2.1 1.0 2.0 0.6 1.0 1.5 1.0 1.9 2.54 YKL152C 1.4 1.3 1.9 0.9 1.3 1.6 1.5 1.0 0.9 1.5 1.7 1.5 2.7 1.0 1.8 2.0 1.1 1.7 3.28 YML054C 1.5 1.8 1.3 3.4 1.3 1.8 1.2 1.5 4.1 1.8 1.4 1.8 2.8 2.1 1.1 7.8 1.1 1.6 0.25 YML100W 0.8 2.7 10.6 1.4 0.9 2.8 2.2 0.7 1.7 1.4 3.2 1.2 3.8 1.2 1.8 2.2 1.0 1.5 0.88 YML125C 0.8 0.9 0.7 0.7 0.9 1.3 1.0 1.3 2.6 1.6 1.0 1.0 2.2 1.6 1.9 0.7 1.2 0.9 2.21 YMR089C 1.0 1.1 0.9 0.9 0.8 1.2 1.2 1.3 5.6 2.5 1.3 0.8 2.3 0.9 1.8 1.1 0.9 1.1 0.69 YMR105C 2.0 3.0 5.0 4.2 0.9 2.8 2.8 1.1 0.6 2.9 3.0 1.7 3.3 1.0 0.9 2.0 1.6 2.6 1.21 YNL237W 1.3 1.3 1.5 1.0 1.5 4.6 4.9 1.1 0.9 2.1 1.5 1.8 3.2 1.3 1.6 4.4 1.3 1.1 0.21 YOL126C 1.1 0.8 1.0 1.6 0.7 1.5 1.4 0.9 0.8 2.4 1.8 1.1 2.6 1.2 1.4 2.5 1.6 2.4 0.59 YOR347C 0.9 0.9 2.1 2.2 0.7 0.9 0.9 0.8 0.5 0.9 1.4 1.2 1.8 0.9 2.0 1.4 1.7 1.3 1.31 YPR026W 0.9 1.2 5.0 1.3 0.8 1.3 1.0 0.9 3.1 1.6 1.2 2.3 1.5 3.1 2.5 0.9 1.3 0.26 YAL038W 1.0 1.0 3.0 1.4 1.4 1.3 0.9 1.1 0.1 1.1 1.0 1.2 1.8 0.5 3.1 0.9 1.0 1.0 7.02 YDR380W 0.8 0.8 0.8 1.7 1.1 0.4 0.5 0.2 0.2 0.3 0.4 0.4 0.4 0.6 2.4 0.2 0.8 0.8 1.04 YLR273C 1.5 1.0 1.3 2.4 1.2 1.2 1.3 2.8 2.4 1.4 0.9 1.7 1.3 2.6 1.5 1.0 1.0 0.20 YGR207C 1.5 1.1 1.0 1.1 1.5 2.8 1.7 1.9 2.1 2.6 1.4 1.1 1.0 2.2 0.6 1.8 1.2 1.8 1.49 YNL037C 1.4 1.8 1.7 1.1 1.7 2.8 2.8 1.0 0.6 3.2 1.4 1.3 1.9 1.3 0.9 1.4 0.9 1.3 2.05 YOR136W 1.0 0.9 3.5 1.0 1.5 3.9 3.2 1.1 0.3 3.4 1.4 1.2 1.5 0.9 1.2 1.3 0.8 1.3 3.20 YPL271W 1.2 3.2 4.1 1.2 1.4 3.3 1.2 0.9 0.6 1.2 1.7 0.8 1.2 1.3 0.8 1.4 1.2 1.3 1.34 YAL054C 1.2 1.1 1.4 1.6 1.1 2.2 1.1 1.1 8.9 4.1 1.3 1.0 1.8 1.3 0.9 2.5 1.5 1.4 0.24 YEL011W 2.0 1.6 1.7 6.3 1.1 2.8 2.7 0.9 2.5 1.6 3.7 1.5 1.5 1.5 0.4 2.4 1.4 2.5 0.89 YFR015C 1.2 0.8 3.2 2.1 1.2 3.0 7.3 0.7 0.3 1.8 3.9 0.4 2.5 3.1 0.4 2.4 1.3 1.2 0.66 YGL253W 0.8 1.0 3.2 0.7 1.3 2.4 1.7 1.1 0.3 1.4 1.0 1.2 1.5 0.5 0.8 0.4 0.7 0.8 4.63 YIL111W 1.9 1.0 1.8 2.7 2.6 3.2 1.2 1.6 1.1 2.1 0.9 1.7 1.5 1.1 2.5 1.9 3.9 1.52 YKL150W 1.1 2.0 3.0 1.4 1.4 2.3 2.4 1.3 1.1 1.3 1.9 1.2 1.8 1.4 0.9 6.1 1.2 2.7 2.20 YPR006C 1.9 1.5 0.5 1.9 2.0 2.4 2.8 1.5 1.5 3.9 2.4 1.1 1.8 1.2 0.7 1.6 1.8 2.1 0.46 YBR145W 1.5 0.7 2.8 0.9 1.1 11.5 58.8 1.0 0.1 1.1 1.1 1.0 2.0 2.2 1.2 3.6 1.7 2.0 2.17 YBR299W 2.0 0.9 1.1 3.5 1.6 0.8 3.6 2.2 1.1 5.3 2.4 1.2 0.7 1.4 0.6 3.9 1.0 1.1 0.32 YEL020C 1.0 1.5 0.8 2.9 1.5 1.3 2.4 1.2 1.4 1.1 1.3 0.8 1.2 1.0 1.4 2.1 1.2 1.3 0.31 YGL134W 1.2 1.3 0.5 0.8 1.4 1.2 2.3 1.4 1.1 1.4 1.1 0.9 0.7 1.1 0.5 1.7 0.9 1.3 0.53 YOL157C 1.0 1.1 1.3 2.5 1.4 0.9 2.7 1.4 2.3 4.8 1.2 1.2 1.4 1.2 1.1 3.5 1.4 1.3 0.41 YBR126C 0.8 1.9 5.6 1.2 0.7 2.9 2.3 0.6 1.7 1.1 1.3 2.1 0.7 1.0 1.7 1.5 1.3 1.96 YCR005C 1.2 1.9 2.0 1.2 0.9 1.6 4.4 1.2 1.5 1.5 2.1 0.5 0.7 0.8 0.7 0.7 1.6 1.7 2.38 YIL172C 1.1 1.1 1.6 1.7 1.3 2.5 1.6 2.8 7.1 1.0 1.4 2.0 1.3 1.4 2.8 1.1 1.2 0.42 YOR221C 0.8 1.0 0.9 1.1 1.7 0.8 2.1 0.9 1.4 1.7 1.1 0.8 1.0 1.1 1.0 1.4 0.9 1.2 0.39 YBR196C 0.8 0.6 3.9 1.4 0.8 0.8 1.4 1.1 0.3 0.9 2.3 1.0 1.4 0.5 1.9 1.1 0.8 1.0 6.60 YEL047C 1.3 1.9 3.2 1.2 0.8 0.6 1.3 1.0 2.7 2.3 4.2 1.2 1.6 1.1 1.0 1.3 0.9 1.0 1.02 YMR318C 1.8 2.4 2.2 0.7 1.2 2.1 0.8 3.6 2.3 4.8 3.6 0.8 1.8 1.7 1.5 1.1 1.1 1.1 3.17 YER061C 0.9 0.9 1.2 2.5 0.8 0.4 0.9 0.7 0.3 0.7 2.2 0.7 0.9 1.0 0.8 1.8 1.2 1.2 0.84 YJL045W 1.8 2.2 1.6 5.3 0.7 0.6 0.7 0.9 9.7 1.6 2.3 1.1 1.6 1.2 3.4 2.4 0.9 0.9 0.42 YLL009C 1.0 1.2 0.6 1.9 1.5 1.2 1.7 1.0 1.3 1.7 3.5 0.7 0.9 1.4 1.1 2.8 0.9 1.2 1.66 YPR160W 1.4 3.8 3.6 3.3 0.7 4.5 1.8 0.9 0.9 1.3 4.4 2.1 2.2 1.1 1.4 5.3 1.0 2.9 1.42 YDL085W 1.2 1.9 1.2 2.0 1.2 1.2 1.4 1.0 7.8 3.4 2.7 0.8 1.7 1.2 0.7 4.5 0.9 0.9 0.23 YJL221C 1.1 1.0 1.1 1.3 0.9 6.6 2.5 1.8 2.7 4.4 0.8 1.1 1.4 1.1 1.1 3.3 1.1 1.4 0.41 YKL085W 1.5 2.3 1.6 1.2 1.2 1.9 1.5 1.2 1.9 3.0 1.8 0.8 1.5 1.0 0.5 1.7 0.9 1.3 2.16 YLR174W 1.2 1.5 1.7 2.1 0.9 0.9 1.6 1.1 2.5 8.3 1.3 1.3 1.8 1.7 0.8 4.6 0.9 1.2 0.41 YNL009W 1.1 1.9 2.0 1.4 1.4 1.1 1.2 1.1 1.4 3.3 1.3 0.9 1.3 1.3 2.7 3.3 1.2 2.3 0.45 YNL117W 0.9 4.7 1.7 0.8 0.8 1.1 1.7 12.8 4.4 1.4 0.7 1.3 2.0 2.6 1.6 1.1 0.9 0.24 YAL061W 1.7 2.4 3.3 3.8 1.0 1.0 2.0 0.8 5.5 1.4 4.1 1.1 1.4 0.7 0.6 1.1 1.4 1.2 0.88 YBR117C 0.8 1.6 1.5 1.4 0.9 2.3 1.0 0.7 5.9 1.5 0.4 0.8 2.1 0.9 1.0 12.0 0.7 0.7 0.49 YEL071W 1.1 1.6 2.6 0.4 1.3 1.9 2.0 1.2 3.6 2.8 2.1 0.9 1.6 1.2 1.6 1.2 1.1 1.2 1.13 YGR112W 1.0 2.9 1.1 1.3 0.9 1.1 1.3 1.3 2.6 1.3 1.3 0.7 1.1 1.1 1.2 2.8 0.9 1.2 0.31 YLR164W 1.0 2.4 0.3 1.0 1.2 1.2 1.1 1.2 5.3 2.0 3.2 0.7 1.0 1.5 0.7 11.0 1.5 1.2 0.31 YNR032W 1.0 1.5 1.0 2.1 1.5 1.0 1.1 1.0 6.2 2.4 1.4 0.6 1.3 1.4 0.9 1.0 1.2 1.3 0.71 YPL031C 0.9 2.0 1.4 0.8 1.5 1.8 1.6 1.0 5.7 1.4 1.4 0.8 1.6 0.9 0.7 2.0 1.4 1.2 0.49 YPR048W 1.3 2.0 0.9 1.1 0.9 0.6 0.9 1.5 4.0 2.1 1.0 0.8 0.6 1.2 0.6 0.8 0.7 0.8 0.75 YBL058W 0.9 1.5 0.5 1.1 1.6 0.9 1.5 1.2 2.6 2.1 1.3 0.8 1.6 1.3 1.8 1.8 1.0 1.4 1.42 YBR001C 0.9 1.4 1.1 1.4 0.9 1.1 0.9 1.3 2.3 2.1 1.0 1.0 2.0 1.2 1.8 1.4 1.0 1.6 0.61 YCR105W 2.2 1.2 1.2 3.0 0.9 1.0 1.0 1.4 2.0 3.9 2.3 0.9 1.9 1.9 3.1 1.3 1.3 1.1 0.36 YIR031C 0.9 1.6 0.6 0.6 1.6 1.7 1.4 1.0 2.6 1.0 1.2 0.8 1.0 1.2 0.8 0.7 0.9 0.8 0.44 YGL191W 2.3 1.6 1.4 1.8 0.9 1.6 1.0 1.6 1.1 1.3 1.6 0.9 1.1 1.6 0.7 1.8 1.2 1.7 2.35 YLR038C 2.6 1.1 0.6 2.1 1.8 1.2 1.0 1.4 0.4 0.9 1.4 0.6 0.5 1.6 0.7 2.1 1.2 2.1 1.52 YGR087C 1.0 15.0 1.7 0.6 1.0 1.1 1.0 0.8 0.2 0.9 0.8 1.2 1.2 0.7 3.5 0.6 1.0 0.6 1.88 YGL256W 0.9 5.3 1.1 1.3 0.7 0.7 0.5 1.0 0.4 1.2 1.0 0.9 0.8 0.9 1.0 0.7 0.7 0.8 0.90 YDL181W 1.4 1.8 1.9 1.8 1.7 1.2 1.1 0.6 0.7 0.8 0.8 0.9 0.9 1.1 0.4 1.1 1.5 1.4 0.85 YPL262W 1.1 1.7 3.8 1.2 0.6 1.6 1.3 1.0 1.4 5.8 1.4 1.1 1.5 1.2 0.6 1.4 1.1 1.2 0.79 YLR377C 1.1 2.6 1.8 1.2 1.0 0.7 0.9 0.7 1.8 1.6 0.6 0.6 1.2 2.9 0.8 2.7 0.9 1.4 0.14 YBR221C 0.8 0.7 3.2 1.5 1.3 1.7 1.5 0.8 1.0 1.3 1.2 1.3 1.7 0.8 1.1 1.5 0.9 1.0 3.62 YKL141W 1.6 1.1 4.7 1.7 1.5 1.2 0.5 0.8 0.8 0.5 1.2 0.8 0.8 1.4 0.6 2.8 0.9 1.8 2.84 YLR134W 0.9 0.6 2.3 0.8 1.3 2.5 1.1 0.8 0.1 0.7 1.1 1.2 1.5 0.6 1.7 0.5 0.6 0.8 3.47 YLR258W 1.7 1.0 4.2 3.5 0.9 1.8 1.8 0.9 0.8 1.3 1.2 0.9 1.4 1.2 0.6 1.7 1.0 2.0 1.36 YOR178C 1.4 1.3 4.8 2.3 1.0 2.7 0.9 0.9 0.2 1.7 4.1 1.7 1.0 1.0 1.1 1.7 1.0 1.5 0.56 YBL099W 0.8 0.9 3.1 1.4 1.0 0.9 0.9 0.8 0.9 0.7 2.1 1.0 0.9 0.6 1.0 0.9 0.7 1.2 3.49 YDR050C 1.9 1.3 2.3 1.8 0.9 1.7 1.5 1.3 0.4 1.3 2.0 1.4 2.0 1.2 1.9 1.3 1.1 2.3 6.26 YDR178W 2.0 2.0 3.4 2.2 0.9 2.1 0.6 0.9 0.9 0.8 2.0 1.3 1.5 1.5 0.7 3.0 1.2 2.3 2.27 YDR298C 1.3 1.2 2.6 1.3 1.3 1.2 1.0 1.2 1.0 1.6 1.2 1.1 1.2 1.5 0.8 2.0 1.1 1.6 2.69 YEL024W 1.5 0.9 3.8 1.1 1.3 1.1 0.7 1.0 0.7 0.6 0.9 0.8 0.6 1.1 0.6 2.1 1.1 1.5 1.59 YJL121C 1.0 0.5 1.9 0.8 1.0 1.1 0.7 1.0 0.1 0.4 1.1 0.6 0.7 0.9 1.0 0.6 1.1 1.0 1.00 YJR121W 1.2 1.1 3.3 1.0 0.8 1.5 1.0 0.7 0.8 1.3 0.9 0.8 1.0 0.7 0.9 1.2 1.1 1.4 3.99 YKL060C 1.7 0.8 2.5 1.0 1.6 1.3 1.2 1.1 0.3 0.8 2.1 1.3 1.2 0.8 1.6 1.5 1.2 1.7 6.01 YKL148C 0.9 0.8 3.7 0.7 0.8 0.5 0.6 0.8 1.7 1.7 1.5 0.8 0.8 0.8 0.6 1.1 0.8 1.0 0.54 YLL041C 1.5 0.5 4.6 1.0 1.6 1.2 0.3 0.8 0.7 0.8 1.3 0.8 1.0 1.2 0.4 3.1 1.1 1.7 1.75 YLR044C 0.8 0.6 2.2 0.9 1.7 1.5 1.3 0.7 0.0 1.2 1.1 1.4 1.7 0.5 2.2 0.6 0.9 0.9 5.16 YLR284C 0.9 1.0 3.8 1.9 1.6 0.9 0.8 1.2 0.9 0.9 1.5 0.6 0.8 1.3 1.0 4.5 2.9 8.1 0.84 YLR304C 0.7 0.6 5.0 0.7 0.6 1.9 0.6 0.6 0.1 2.2 1.6 1.0 0.5 0.7 1.6 1.8 0.5 0.7 2.39 YLR354C 1.2 2.5 2.3 1.5 1.6 1.5 1.1 1.4 0.4 0.9 1.7 1.2 1.0 0.9 2.4 1.3 1.0 1.5 4.53 YMR205C 0.5 0.7 2.3 0.8 1.2 1.2 0.9 0.7 0.3 0.8 1.0 1.1 1.3 0.5 0.9 0.9 0.6 0.5 4.75 YMR261C 0.8 1.6 3.6 0.8 0.9 0.6 1.3 0.7 1.6 1.3 0.8 0.9 1.6 0.6 0.8 1.6 0.7 1.1 0.78 YMR323W 0.8 1.1 2.9 1.1 0.7 0.4 1.1 0.8 0.5 1.3 2.5 1.2 1.8 1.2 37.3 0.6 1.1 0.6 1.04 YOL086C 1.1 0.5 2.2 1.1 1.9 1.7 1.9 0.8 0.1 1.2 2.6 1.3 1.7 0.6 1.6 1.4 1.1 1.3 4.19 YOR142W 1.3 1.2 3.4 1.0 1.4 1.6 1.0 0.8 1.1 1.5 1.5 0.8 1.4 0.8 1.1 0.8 0.9 1.0 1.31 YPL061W 0.4 1.4 5.0 1.3 1.6 1.7 0.5 0.8 1.3 0.7 1.1 1.0 1.1 0.6 1.7 1.0 1.6 2.6 3.23 YDL107W 1.3 1.3 1.0 2.2 1.0 1.3 1.8 1.8 1.2 1.8 1.0 1.0 1.2 1.5 1.0 2.0 1.1 1.5 0.51 YDR529C 1.8 1.0 0.9 3.2 1.2 0.8 0.5 1.3 0.5 0.6 0.8 0.6 0.7 1.5 0.5 1.8 1.0 2.3 3.11 YGL018C 1.5 1.0 1.8 3.0 1.1 0.4 1.1 0.8 0.5 1.4 1.1 1.0 1.3 1.2 1.1 1.5 0.8 1.0 0.36 YBR185C 1.5 1.0 1.3 2.0 0.8 1.2 1.2 1.1 0.9 1.6 1.2 0.7 1.0 1.7 1.0 1.7 0.8 1.3 0.89 YEL039C 1.1 0.7 1.3 5.1 0.9 1.5 0.6 1.1 1.2 1.2 1.7 0.6 0.5 1.4 0.4 3.5 0.7 1.1 1.59 YGR174C 1.1 1.6 0.6 2.4 1.0 1.4 1.0 1.6 1.8 0.7 1.3 0.9 1.5 1.6 0.7 3.2 1.3 2.3 1.05 YKL016C 1.5 1.3 0.7 1.7 1.5 0.8 1.5 1.6 1.3 1.8 1.3 1.0 1.3 1.6 0.7 1.8 1.0 1.7 2.08 YLR395C 1.8 1.3 2.2 1.9 0.7 0.4 1.0 1.0 0.9 1.5 0.6 0.5 1.7 0.4 1.2 1.2 2.3 1.76 YML120C 1.1 1.2 1.9 1.9 0.6 0.6 0.8 0.9 1.3 1.5 1.3 0.9 1.2 0.8 0.5 1.5 1.0 1.6 0.74 YMR073C 1.1 1.1 1.2 1.5 0.8 0.9 1.0 1.1 1.2 1.2 0.9 0.8 1.2 2.0 0.9 1.5 0.8 1.2 0.69 YOR388C 1.0 1.6 1.3 4.7 1.3 1.4 1.0 0.7 0.1 1.4 1.3 0.7 1.1 1.3 4.0 0.8 1.0 0.9 0.21 YPL275W 0.6 1.5 1.3 5.1 1.2 1.0 1.1 1.0 0.2 1.2 0.9 0.6 1.0 1.0 1.4 0.9 1.0 1.0 0.28 YPL276W 1.2 1.5 1.6 3.0 1.5 1.1 1.2 0.9 −0.2 1.8 −0.4 0.6 0.9 0.9 1.0 0.6 1.1 0.8 0.22 YGL205W 1.0 0.9 0.7 0.8 1.1 1.6 0.8 1.2 0.5 0.6 0.4 1.1 1.0 1.0 2.0 4.1 3.9 9.1 0.24 YJL166W 2.1 1.5 1.6 1.3 1.6 0.7 0.8 1.4 1.3 1.2 1.4 0.7 0.8 1.9 0.5 2.3 1.7 4.0 2.31 YNL202W 0.7 1.3 1.2 1.7 0.9 2.0 0.9 1.2 1.3 1.1 1.2 0.9 1.8 1.0 1.4 4.2 2.4 3.3 0.47 YDR377W 1.3 1.1 1.3 1.4 1.9 1.3 1.1 1.3 1.0 0.9 1.4 0.9 0.7 1.4 0.6 1.8 1.2 2.5 3.00 YGL187C 1.5 0.8 1.6 1.8 1.3 1.1 0.6 0.7 0.6 0.6 0.7 0.8 0.7 0.9 0.3 1.4 0.9 2.4 2.73 YJL216C 1.1 4.7 2.2 0.9 0.8 1.5 1.9 1.5 1.3 1.1 1.0 1.1 1.1 1.2 1.5 1.2 2.0 0.25 YKR009C 1.0 1.2 1.5 0.9 1.0 1.8 1.0 0.9 2.4 2.1 1.2 1.0 1.8 1.0 1.0 4.6 1.9 2.5 0.27 YCR046C 1.0 1.2 1.2 1.6 1.0 0.8 1.2 0.9 1.9 1.4 1.5 1.1 1.5 1.3 1.4 2.8 1.3 1.0 0.63 YML129C 1.1 0.9 0.9 1.2 1.7 1.7 1.8 1.2 1.4 2.2 1.2 0.8 1.0 1.4 1.1 2.9 1.3 1.3 1.04 YPR184W 1.2 1.4 5.7 2.2 0.9 1.5 1.3 0.7 1.9 3.2 3.6 1.4 2.5 1.3 1.5 3.1 1.0 1.7 0.37 YDL067C 1.8 1.0 1.6 1.3 2.0 0.9 0.8 1.1 0.9 0.9 1.4 1.0 0.6 1.4 0.7 1.8 1.2 1.7 1.85 YDL078C 0.7 1.1 1.2 0.8 1.3 1.1 1.7 1.0 1.1 1.0 1.7 0.8 1.0 0.8 0.5 2.2 1.1 2.0 1.65 YDR079W 1.3 1.1 0.8 1.1 1.2 1.7 1.3 2.6 0.9 0.8 1.3 1.1 1.3 1.5 0.6 2.6 1.1 1.3 1.06 YGR062C 0.9 1.0 0.7 1.4 0.7 0.9 1.3 0.8 1.0 1.4 1.6 1.0 1.5 1.2 0.5 1.8 0.9 1.1 0.54 YKR058W 1.3 0.9 1.4 1.9 0.8 1.4 1.4 1.5 1.3 1.2 1.5 0.9 0.7 1.3 0.5 2.6 0.8 1.6 0.73 YLR295C 1.5 1.1 1.1 1.7 2.2 1.1 1.1 1.2 1.4 1.2 1.3 0.5 0.8 1.2 0.5 2.4 0.9 1.5 1.07 YMR267W 0.8 1.8 0.7 0.9 1.0 1.4 1.2 1.5 0.4 0.8 1.0 0.8 0.7 1.0 0.9 2.6 0.9 1.3 0.94

TABLE 5 Transport facilitation protein genes The level of expressed mRNA in the presence of chemical substance/ The level of expressed mRNA in the absence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YBR008C 3.0 2.4 4.9 0.7 0.9 1.0 0.9 2.8 54.6 21.1 9.4 0.8 2.0 4.1 0.8 3.1 2.0 1.2 0.37 YBR296C 7.0 4.3 2.2 2.5 1.4 1.4 0.2 1.1 0.4 1.8 1.5 1.6 2.0 2.3 1.7 0.3 3.8 4.0 0.54 YDR406W 0.8 1.2 3.1 1.1 1.0 5.9 1.8 0.6 1.1 1.7 1.4 3.9 7.7 0.5 0.8 5.5 2.7 5.6 0.53 YOR153W 1.6 0.9 5.1 1.1 1.0 7.4 2.6 0.5 3.2 1.2 1.0 4.0 11.8 0.3 3.6 1.6 2.5 3.1 1.91 YGR281W 1.2 1.0 1.3 2.2 0.6 1.9 0.9 0.7 2.7 1.4 0.7 2.4 12.9 0.9 2.1 1.1 2.8 3.1 1.04 YHL047C 0.6 4.4 1.0 1.0 1.2 8.4 16.8 1.5 1.2 11.9 1.0 2.6 3.8 0.5 1.1 2.3 1.2 1.2 0.74 YBR294W 6.3 14.4 0.9 2.6 1.4 1.2 1.1 1.0 5.2 5.2 1.2 1.0 3.1 1.3 1.0 0.9 1.0 0.9 0.18 YGL006W 2.5 1.3 1.3 2.6 1.0 1.0 1.3 0.9 3.0 1.2 0.8 0.9 4.5 0.9 1.1 1.7 2.4 4.1 1.37 YGR197C 1.1 2.4 2.5 1.0 0.7 0.5 1.3 0.8 16.7 3.2 1.1 1.2 2.4 1.5 1.0 1.5 1.7 1.9 0.37 YJL034W 0.7 1.7 3.0 0.8 1.2 1.1 1.3 1.5 2.8 1.1 1.3 1.6 6.1 0.6 7.9 0.6 1.1 1.0 4.58 YNL055C 1.1 1.8 5.5 2.0 0.9 2.6 1.2 0.7 1.1 1.0 1.9 1.7 2.4 0.9 1.1 2.6 1.2 1.7 4.10 YBR052C 1.6 1.6 1.5 2.6 1.4 2.1 3.0 1.3 2.3 2.5 1.7 1.3 2.1 1.5 0.7 3.1 1.8 3.1 2.77 YBR207W 0.8 1.7 0.8 2.0 1.7 1.6 4.3 0.9 1.7 2.2 1.1 0.9 2.2 0.9 1.4 1.4 1.2 1.4 1.39 YBR293W 1.9 3.1 1.0 1.8 0.8 0.9 0.9 0.9 5.5 2.4 1.1 1.0 3.0 1.4 3.1 1.6 1.0 0.9 0.94 YDL198C 1.4 1.0 2.1 1.4 0.7 0.8 1.0 1.1 1.9 2.7 2.5 1.2 2.0 1.7 1.2 1.4 1.5 1.1 1.19 YDL245C 1.0 2.4 1.6 2.2 1.3 1.1 1.2 1.2 0.4 2.8 1.5 1.0 2.0 1.2 1.8 1.5 1.0 1.1 0.28 YDR497C 0.7 0.5 0.6 1.3 0.7 0.6 0.5 0.6 0.4 0.8 0.7 0.9 2.7 0.6 10.1 1.6 1.8 1.45 YER053C 1.6 1.8 1.9 1.7 0.6 2.8 2.8 1.3 1.3 3.9 2.4 1.7 4.1 1.3 1.1 2.8 1.2 2.3 1.83 YFL041W 0.7 1.6 1.4 1.2 1.2 2.0 3.4 1.0 0.8 5.1 0.9 1.1 1.8 1.0 0.9 1.4 1.1 0.9 0.89 YGR055W 2.5 5.7 12.0 0.7 1.3 1.1 0.6 1.1 5.0 2.4 1.5 0.9 1.9 1.2 2.1 0.6 0.7 0.7 1.42 YJL219W 1.2 2.5 3.1 1.6 1.2 1.5 0.9 1.5 4.0 2.3 2.3 1.1 4.0 1.1 2.6 1.4 1.6 1.2 0.91 YJR106W 0.9 3.8 1.5 1.1 0.9 1.2 1.0 0.9 2.0 1.6 1.6 0.9 3.5 0.9 1.2 1.9 1.2 1.3 0.29 YKL146W 0.8 1.3 1.3 0.9 1.0 1.3 0.9 0.8 4.6 2.8 0.9 1.1 2.7 1.0 1.5 1.3 1.0 0.9 0.42 YLL028W 0.6 0.9 4.6 0.5 0.9 1.7 1.0 0.7 1.2 2.3 0.7 1.3 4.1 0.7 3.1 0.6 1.2 1.2 1.02 YLR348C 1.1 4.5 1.2 1.2 0.9 1.9 0.9 0.9 2.1 1.3 1.3 0.9 1.9 1.0 2.4 1.1 1.1 1.0 0.64 YOL119C 2.6 4.8 1.5 2.3 1.5 0.9 2.2 2.0 5.0 7.4 3.4 0.9 1.6 2.4 4.7 2.8 1.4 1.0 0.37 YOL163W 1.5 3.2 2.1 3.3 0.9 0.5 0.9 1.1 7.5 6.2 1.6 1.0 2.4 1.2 1.0 1.4 0.8 0.8 0.30 YOR035C 1.2 1.2 0.3 1.2 1.0 1.9 1.3 1.0 1.3 1.7 1.0 1.1 2.5 0.9 3.8 1.8 1.6 2.1 0.52 YOR130C 0.8 1.7 1.4 1.0 1.8 1.6 1.3 0.8 2.0 1.7 0.6 0.9 2.1 1.3 1.0 0.8 1.5 1.1 0.51 YOR273C 0.7 1.0 1.7 1.0 1.1 0.4 0.4 0.6 0.6 0.5 1.5 0.8 2.6 0.5 0.8 0.6 3.2 3.1 1.20 YOR332W 1.1 1.0 1.0 1.0 0.9 1.8 0.9 1.5 1.8 1.1 1.5 1.0 2.2 1.1 1.2 1.2 1.3 1.7 3.58 YCR098C 1.6 3.0 1.7 2.0 1.4 1.6 1.2 1.0 1.4 2.4 1.3 1.3 1.4 1.1 11.0 0.8 1.7 1.6 0.22 YGR138C 1.1 1.6 1.0 1.2 0.8 0.8 0.7 1.0 0.5 1.0 0.7 0.6 0.6 0.9 4.5 0.7 0.7 0.7 1.24 YBR295W 1.4 1.5 3.3 1.1 0.8 1.6 0.9 1.2 3.3 1.1 0.9 1.8 1.1 4.8 1.4 1.3 1.2 0.27 YGL255W 0.7 0.9 0.9 0.8 1.4 1.1 1.0 0.7 0.3 5.0 0.5 0.7 0.2 1.0 2.6 0.5 0.6 0.5 1.36 YHL035C 0.7 1.3 0.9 1.9 0.9 4.1 1.7 1.1 0.6 4.6 0.9 1.4 1.1 0.8 3.1 2.4 1.1 1.2 0.77 YIL022W 0.8 0.7 1.1 1.6 0.8 1.2 0.7 0.8 1.1 1.3 1.0 0.9 1.2 0.6 2.9 1.1 0.8 0.7 0.52 YLR378C 0.7 0.9 2.6 0.5 1.0 1.2 0.7 0.5 1.1 0.7 1.0 1.2 1.6 0.4 5.9 0.4 0.9 0.7 1.23 YCL038C 1.6 1.6 1.4 1.6 1.2 3.2 1.5 1.2 1.1 0.9 2.0 1.3 1.9 1.3 2.0 1.8 1.4 1.5 1.04 YFL054C 1.6 1.1 1.4 2.2 1.3 2.4 1.1 1.5 2.0 2.3 1.7 1.2 2.3 0.9 1.4 1.3 1.7 1.4 1.06 YHL040C 1.6 4.9 1.5 0.4 1.1 7.3 4.0 1.5 1.1 11.3 1.7 2.0 2.0 1.1 3.4 1.0 1.4 1.0 0.69 YKR039W 1.4 3.5 1.3 1.7 1.0 2.8 1.0 1.0 1.9 2.0 1.9 1.5 1.3 1.2 1.7 1.9 0.9 1.1 0.40 YPL271W 1.2 3.2 4.1 1.2 1.4 3.3 1.2 0.9 0.6 1.2 1.7 0.8 1.2 1.3 0.8 1.4 1.2 1.3 1.34 YBR068C 1.1 1.0 1.9 2.5 1.4 1.9 1.0 0.8 2.5 0.8 0.8 2.2 1.8 1.6 5.5 1.1 1.3 1.99 YCR037C 0.7 1.0 0.8 0.8 1.3 1.8 1.0 0.7 0.6 0.6 0.8 0.7 1.3 0.8 1.0 1.1 1.4 0.9 0.74 YDL128W 0.8 1.1 2.1 1.0 1.0 2.3 0.9 0.8 0.5 0.7 1.2 0.9 1.6 0.7 1.1 1.0 0.9 1.0 2.80 YDR270W 0.7 1.5 1.4 1.3 1.0 2.2 1.7 1.2 2.9 3.6 1.0 1.0 1.8 1.0 1.4 1.1 0.9 0.7 0.38 YEL065W 0.3 3.8 1.2 0.4 1.4 2.3 4.3 0.9 0.1 4.9 0.6 1.7 0.8 0.4 2.2 2.6 0.7 0.6 2.10 YGL008C 0.6 0.7 3.1 0.9 0.8 1.9 1.4 0.7 0.0 0.4 0.7 2.4 1.9 1.2 1.0 2.1 1.1 1.0 4.08 YGL104C 0.8 2.0 2.1 1.8 1.0 2.1 1.2 0.8 4.6 2.1 1.8 1.1 2.0 1.0 0.9 1.7 1.3 1.3 0.58 YGL167C 0.9 0.7 1.6 1.3 1.2 2.0 1.2 0.8 1.3 1.1 0.8 1.1 1.5 0.8 1.3 1.3 1.4 1.4 1.41 YGR065C 0.8 1.5 2.6 1.1 1.2 2.4 2.4 1.0 1.2 2.6 1.1 0.5 0.8 1.3 1.2 1.1 0.7 0.7 0.68 YHR092C 2.3 1.0 7.5 2.5 1.4 1.7 0.5 1.5 0.2 0.9 1.5 1.0 0.5 1.6 0.2 1.2 0.9 1.3 6.09 YIL088C 0.9 2.1 2.1 1.3 1.6 2.2 1.7 0.8 1.0 1.7 1.8 0.9 1.5 1.2 1.2 1.8 1.2 1.4 1.89 YNL259C 1.6 3.5 1.1 1.2 1.1 3.9 3.8 1.5 1.6 2.1 1.6 0.7 1.1 1.4 0.7 1.7 2.6 2.4 1.22 YOR270C 0.7 0.5 2.0 0.8 0.8 1.8 1.0 0.6 0.4 0.9 1.5 0.7 1.3 0.7 1.1 0.8 0.9 0.9 3.49 YPL265W 0.7 0.4 2.3 1.1 1.0 2.3 8.9 2.3 0.2 1.2 1.8 0.9 1.1 1.1 1.2 2.0 0.5 0.4 1.42 YPR124W 0.2 0.4 0.3 1.4 2.0 2.0 2.9 2.7 0.2 1.5 2.0 0.8 0.6 0.4 1.1 2.4 1.0 1.3 2.57 YER119C 0.7 2.1 1.8 0.7 0.8 1.3 0.8 0.6 5.8 1.2 2.2 0.7 1.6 1.0 2.3 0.8 1.0 0.9 0.32 YFL055W 2.0 6.7 1.3 2.5 1.5 1.1 1.4 1.3 23.9 6.5 2.7 0.9 1.3 1.5 0.7 1.4 1.4 1.0 0.23 YLL055W 2.6 19.0 4.8 1.7 1.0 1.4 1.7 1.4 19.1 14.0 3.6 0.7 1.5 1.3 0.7 2.8 1.1 1.3 0.47 YHL036W 2.2 4.8 3.4 2.0 1.3 1.3 1.0 1.2 9.0 4.4 2.3 1.2 1.5 1.2 0.9 1.1 1.0 1.0 0.60 YHR048W 2.5 1.4 1.4 1.7 1.0 0.8 0.8 1.9 4.5 2.7 2.0 0.9 1.1 1.7 0.9 1.4 0.7 0.9 0.26 YKL221W 1.3 0.7 2.0 1.0 1.0 0.9 1.3 1.2 7.3 2.7 1.9 0.7 1.6 1.4 1.1 1.3 0.8 0.9 0.27 YLR092W 5.0 5.6 1.4 0.6 1.3 1.0 1.3 1.5 12.7 5.8 3.1 1.0 1.8 1.4 0.9 1.2 1.0 1.1 0.24 YML116W 4.1 1.3 1.5 1.4 1.2 0.9 1.4 2.2 1.4 3.1 4.3 0.5 0.8 2.0 1.9 1.0 1.0 1.0 0.94 YBR291C 2.0 0.9 1.0 1.5 0.9 1.1 0.9 2.2 0.9 1.0 1.1 0.9 1.0 1.7 0.5 1.5 0.9 1.3 1.19 YCL069W 0.9 4.5 0.9 0.8 0.9 1.4 1.3 1.2 6.9 1.0 0.9 0.8 1.3 1.4 0.9 1.0 1.0 0.25 YJR095W 1.2 20.5 1.9 6.7 1.2 1.5 2.0 0.9 0.5 6.3 0.6 0.7 0.8 1.3 0.8 0.8 1.3 0.9 0.23 YKL188C 1.3 0.7 1.9 2.4 1.0 0.8 1.1 0.7 2.5 2.8 1.1 1.2 1.2 2.1 1.4 2.7 1.1 1.5 0.27 YKL217W 1.8 2.4 1.0 2.1 1.1 1.2 1.6 1.1 0.9 4.1 1.6 0.8 1.2 1.2 2.2 3.0 1.7 3.3 0.29 YKR105C 0.8 0.9 0.9 1.5 1.0 1.2 1.0 1.3 1.0 5.2 0.0 0.8 2.5 1.2 1.5 0.7 0.8 1.0 0.26 YOL158C 0.7 4.0 2.4 0.9 1.2 2.0 1.6 0.7 1.7 6.1 0.7 0.9 1.4 1.0 0.9 1.2 1.4 1.7 1.30 YPL224C 1.0 2.2 1.3 2.5 0.6 1.3 2.2 1.3 3.2 4.2 0.8 1.1 1.3 1.4 1.0 2.5 1.3 1.9 0.64 YPR201W 33.2 0.9 1.1 1.0 1.2 1.9 0.8 0.9 8.3 5.6 2.2 0.7 1.1 1.8 0.8 0.9 0.8 0.9 0.29 YAL067C 2.7 12.1 1.5 1.4 0.7 1.2 0.8 1.1 7.6 2.9 1.2 1.0 1.1 1.3 2.4 1.6 1.0 1.0 0.33 YDL149W 0.8 2.0 1.2 1.6 1.5 1.0 0.7 1.2 3.2 2.0 1.2 0.7 1.5 1.2 1.8 1.4 0.8 1.0 0.33 YJL094C 1.0 1.7 1.3 2.0 1.4 1.3 1.7 0.8 5.4 2.9 1.1 1.2 2.6 1.0 1.0 1.8 2.1 2.0 0.84 YLL061W 3.6 2.8 9.2 0.4 0.8 0.8 0.9 1.4 3.7 5.5 1.7 0.7 0.9 1.3 1.4 1.0 0.6 0.7 0.33 YPL274W 0.8 4.2 3.8 0.8 0.6 1.1 0.7 0.9 4.1 3.6 2.0 0.5 0.6 0.9 1.5 1.1 0.7 0.6 0.41 YBR241C 0.9 9.3 2.6 0.9 0.9 1.5 1.4 0.7 29.8 2.2 1.4 1.4 1.4 0.9 1.6 0.7 1.0 1.2 1.25 YDL206W 0.9 1.7 1.8 1.4 1.1 5.7 2.0 1.1 1.6 1.5 0.6 1.0 1.3 1.0 1.1 3.1 1.0 1.1 0.35 YDR040C 0.7 1.4 3.7 0.8 1.0 1.7 0.7 0.8 2.0 1.2 0.8 0.9 1.8 0.9 0.8 1.4 1.4 1.6 1.25 YFR045W 1.1 1.6 1.1 1.1 1.0 1.0 0.6 1.0 2.2 1.0 1.4 1.0 1.1 1.0 1.1 0.6 0.9 0.8 0.84 YIL170W 1.1 1.0 2.5 2.2 0.9 8.8 0.5 1.2 5.7 3.2 1.7 0.7 1.9 1.1 2.3 1.8 1.6 1.5 0.48 YKL192C 1.1 1.0 3.7 1.1 1.1 1.8 1.1 0.9 3.5 1.6 1.1 1.2 1.7 1.5 1.2 2.1 1.0 0.8 1.57 YKL209C 1.0 1.0 1.3 0.8 1.2 3.3 0.9 1.4 2.4 1.6 0.8 0.9 1.4 1.1 1.0 1.1 1.1 1.0 0.30 YKR106W 1.3 0.8 2.1 1.4 1.2 1.6 0.9 1.3 10.5 7.4 1.8 0.8 1.4 1.7 2.8 0.9 0.8 0.16 YMR056C 1.1 1.3 1.7 1.0 1.1 0.9 1.4 1.2 1.8 1.1 1.6 0.9 0.9 1.1 0.7 2.4 1.0 1.1 0.72 YPL147W 1.0 0.8 2.3 1.2 1.2 1.1 1.0 0.9 2.4 2.4 1.3 0.9 1.5 1.0 2.4 2.5 1.5 3.6 0.33 YIL166C 1.9 12.5 2.1 1.2 1.0 1.9 1.3 2.5 2.9 1.8 0.9 1.5 1.1 1.3 0.7 1.2 0.9 0.26 YMR058W 0.3 5.1 2.1 0.3 0.8 2.6 1.8 0.8 0.2 1.4 0.8 0.8 0.4 0.3 0.5 0.4 0.6 0.5 1.66 YNL142W 0.7 2.4 2.5 0.8 1.3 0.9 1.1 0.8 0.9 0.6 0.9 1.2 0.9 0.8 0.3 1.0 1.0 0.9 0.44 YDL210W 1.2 2.2 2.7 1.1 0.9 1.3 0.8 1.1 1.2 1.4 0.6 0.8 1.2 1.1 1.9 0.9 1.1 0.9 0.20 YCL025C 1.1 4.6 2.5 1.7 0.9 0.9 0.7 0.7 0.3 0.3 1.0 1.1 0.5 0.7 0.8 0.6 0.6 0.6 1.98 YJL212C 0.8 3.2 3.1 0.5 1.2 1.1 0.7 0.7 1.1 1.3 0.9 0.4 1.0 0.8 0.3 0.5 0.6 0.5 0.59 YBR132C 0.9 1.9 2.4 1.8 0.8 1.2 1.1 0.8 0.8 1.1 1.9 1.0 1.4 1.1 1.5 1.3 1.1 1.3 0.43 YBL030C 1.0 0.9 4.5 0.9 0.7 1.1 0.9 0.8 0.4 0.9 1.1 0.9 0.5 0.8 1.8 1.0 1.0 1.1 3.12 YCR024C-A 0.8 0.9 3.2 0.9 1.2 0.8 0.8 0.2 0.7 1.5 1.0 0.5 0.8 1.3 1.5 0.9 1.4 4.02 YDR342C 2.8 1.1 12.2 5.7 1.6 1.1 0.8 1.2 0.2 2.2 2.9 1.0 0.6 0.9 0.5 2.4 1.0 2.2 5.23 YDR343C 1.2 1.0 20.6 4.6 1.3 1.3 0.7 1.2 0.3 2.1 2.3 1.0 0.8 0.8 0.5 2.8 1.1 2.3 5.81 YEL027W 1.2 0.6 3.4 1.1 1.0 1.1 0.8 0.9 0.9 1.1 0.9 0.9 0.7 1.4 1.5 1.6 1.0 1.4 4.75 YHR094C 0.7 1.2 5.3 1.6 1.1 1.6 0.8 1.2 0.3 1.2 0.6 0.9 0.7 0.6 2.7 0.9 1.4 1.4 4.82 YHR175W 0.8 2.0 2.4 1.5 0.9 1.0 1.6 0.9 0.6 2.0 1.1 1.4 1.2 0.7 1.3 2.3 1.3 1.2 1.01 YIL056W 1.1 0.9 6.2 1.4 1.2 1.0 0.6 0.7 1.2 1.6 0.7 1.0 1.5 1.0 0.5 0.9 1.5 1.2 0.71 YMR203W 0.8 0.7 3.0 1.4 0.6 1.1 0.8 0.7 0.7 1.2 2.3 0.7 1.1 0.7 1.2 0.9 0.8 0.7 1.62 YBL099W 0.8 0.9 3.1 1.4 1.0 0.9 0.9 0.8 0.9 0.7 2.1 1.0 0.9 0.6 1.0 0.9 0.7 1.2 3.49 YBR127C 0.8 0.7 2.2 1.1 1.4 1.1 0.9 1.1 0.6 1.3 1.1 0.9 0.9 0.6 1.3 1.4 0.8 1.0 4.59 YDR038C 0.6 1.3 3.1 0.9 0.9 1.8 0.7 0.9 1.4 0.9 0.9 0.7 2.0 0.8 0.8 1.4 1.3 1.5 1.32 YDR039C 0.6 1.6 3.2 0.9 1.3 1.1 0.8 0.6 1.8 1.0 0.9 0.8 1.8 0.9 1.2 1.4 1.1 1.6 1.39 YDR298C 1.3 1.2 2.6 1.3 1.3 1.2 1.0 1.2 1.0 1.6 1.2 1.1 1.2 1.5 0.8 2.0 1.1 1.6 2.69 YDR345C 0.8 0.9 5.6 2.6 1.3 1.2 1.1 1.2 0.2 1.1 1.5 1.4 1.2 0.8 0.8 1.0 1.3 1.8 5.65 YEL063C 0.7 0.8 2.4 1.3 1.2 1.3 0.7 0.6 0.8 1.7 0.8 1.1 1.1 0.8 1.3 1.0 0.7 0.7 1.12 YFL011W 1.2 0.7 3.7 3.3 1.3 1.0 0.8 0.8 0.3 1.6 2.1 0.9 0.8 0.8 1.7 1.2 0.8 1.0 1.25 YGR082W 1.0 0.9 2.2 1.0 0.9 1.1 0.9 0.8 0.6 0.9 1.3 0.8 0.5 0.9 1.2 1.3 0.9 0.8 1.47 YGR191W 0.8 0.7 1.6 1.5 0.8 1.1 0.7 0.7 0.1 0.7 1.6 0.7 1.0 0.7 1.5 0.7 0.8 0.8 1.58 YGR260W 0.6 0.7 3.4 0.8 0.8 0.9 0.9 0.5 0.3 0.4 1.3 0.6 0.5 0.7 1.8 1.0 0.9 0.9 1.71 YHR026W 0.9 1.0 1.9 1.0 1.1 1.3 0.9 1.6 1.1 0.9 1.4 0.7 0.7 1.3 2.4 1.2 0.9 1.1 3.40 YJR077C 1.1 1.1 2.0 1.6 0.9 0.9 0.7 0.8 0.4 0.7 1.6 1.0 0.9 0.7 1.5 0.7 1.0 0.8 1.79 YJR121W 0.9 1.1 3.3 1.0 0.8 1.5 1.0 0.7 0.8 1.3 0.9 0.8 1.0 0.7 0.9 1.2 1.1 1.4 3.99 YLR081W 1.3 0.8 2.8 3.6 1.0 0.9 0.7 0.9 0.1 2.2 2.6 1.0 0.6 1.0 0.7 1.2 0.7 0.9 1.46 YMR011W 1.3 1.0 9.4 5.5 0.9 0.6 0.8 1.1 0.0 0.7 1.5 0.8 0.4 0.6 0.6 1.2 1.3 1.6 4.95 YOL156W 1.1 0.7 2.5 1.1 1.2 1.2 1.0 1.0 2.3 2.1 1.1 0.9 1.7 0.9 1.9 0.9 0.9 0.9 0.53 YPL036W 0.5 0.8 2.8 0.9 1.3 0.7 0.3 0.5 0.1 0.3 0.8 0.5 0.3 0.6 1.0 0.7 0.4 0.5 3.66 YGR096W 1.5 1.0 1.1 4.6 1.2 1.7 0.9 1.0 0.8 0.8 0.8 0.8 1.1 1.2 0.9 0.8 0.8 1.0 0.49 YIL006W 1.0 1.1 1.4 2.9 0.8 0.3 0.8 0.6 0.9 1.1 1.0 0.9 0.8 1.0 1.5 1.7 0.8 0.9 0.28 YKL016C 1.5 1.3 0.7 1.7 1.5 0.8 1.5 1.6 1.3 1.8 1.3 1.0 1.3 1.6 0.7 1.8 1.0 1.7 2.08 YKR067W 0.8 2.6 1.5 2.5 1.3 1.8 2.0 0.8 1.6 2.3 1.3 1.0 1.3 1.3 1.3 2.0 0.8 1.0 0.58 YMR162C 0.8 1.1 1.1 2.0 0.9 1.0 0.8 0.8 0.7 1.0 1.7 0.7 0.9 1.0 1.0 0.8 0.8 1.1 0.32 YOR348C 1.1 0.7 1.2 2.0 0.9 0.7 0.8 0.8 0.5 0.4 1.1 0.7 1.1 1.2 1.6 1.7 0.9 0.9 0.18 YPR192W 0.9 1.1 0.9 5.0 1.2 0.9 0.9 0.6 0.7 1.3 0.7 0.5 1.1 0.7 1.7 2.6 1.6 0.9 0.28 YPR194C 2.2 1.4 0.5 2.9 1.3 1.5 0.7 1.0 0.5 0.6 0.7 0.7 1.0 1.0 0.4 0.8 1.0 0.9 0.27 YDR086C 1.3 1.0 1.2 1.4 1.0 0.8 2.0 1.9 0.6 0.8 1.1 0.7 0.7 1.5 2.1 1.3 1.4 1.9 2.60 YGR224W 0.9 1.2 1.2 1.2 1.4 0.8 0.4 0.6 0.9 0.9 0.8 0.6 0.8 0.9 1.1 1.0 2.8 1.3 0.27 YDR387C 0.8 0.9 1.2 2.2 0.9 1.2 1.3 0.7 1.4 2.0 2.0 0.9 1.3 0.9 1.4 2.7 1.2 1.1 0.86 YFL050C 0.7 1.0 1.1 2.2 1.0 0.9 0.8 0.9 0.5 1.6 1.2 0.9 1.2 1.0 1.4 2.3 0.8 1.0 0.36 YBR298C 1.1 1.0 1.6 2.3 1.4 0.4 1.7 0.5 0.3 1.1 1.5 1.1 0.8 0.9 0.2 2.1 0.9 0.8 0.88 YLR295C 1.4 1.1 1.1 1.7 2.2 1.1 1.1 1.2 1.4 1.2 1.3 0.5 0.8 1.2 0.5 2.4 0.9 1.5 1.07 YNR072W 1.1 1.5 0.5 0.7 1.0 0.9 1.5 0.9 0.7 1.8 1.4 1.0 1.5 1.0 1.8 2.1 1.3 1.0 0.26 YOR316C 0.7 2.5 1.5 1.5 1.0 0.9 1.4 0.8 1.6 2.0 2.4 1.1 1.6 1.0 1.5 2.2 0.8 1.0 0.93 YOR328W 1.0 1.0 1.0 1.0 2.9 1.1 1.8 0.8 3.3 2.1 0.19 YPL134C 1.5 1.0 1.6 1.6 1.4 1.2 1.2 1.3 0.6 0.8 1.7 0.8 1.0 1.4 1.1 3.3 1.3 1.3 0.70

TABLE 6 Stress protein genes The level of expressed mRNA in the presence of chemical substance/ The level of expressed mRNA in the absence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YBR072W 18.5 17.4 18.4 10.5 1.2 32.2 6.6 2.1 29.4 43.4 6.3 16.3 38.5 5.8 4.9 23.1 1.8 2.2 0.59 YFL014W 3.4 5.1 5.7 11.0 1.0 9.3 5.5 3.4 13.1 5.8 5.0 4.3 15.2 7.3 6.3 14.2 1.5 8.8 2.14 YLL060C 12.5 4.2 2.3 2.6 0.9 1.4 2.0 5.8 13.0 23.2 14.1 1.1 1.8 10.6 1.5 3.6 1.9 2.3 0.57 YAL005C 0.6 1.6 7.0 0.9 1.2 1.6 1.2 0.9 3.9 1.8 1.0 1.2 5.0 0.4 1.6 0.7 0.8 0.5 5.23 YBL075C 1.3 4.3 3.1 1.6 1.1 0.8 1.3 0.8 60.3 6.7 1.6 1.1 8.0 1.1 2.6 2.2 1.2 0.7 1.17 YBR169C 1.0 2.1 3.9 1.9 0.8 4.9 2.5 0.9 7.0 4.3 2.2 1.7 7.2 1.1 1.6 2.4 1.3 1.6 1.10 YCL035C 2.0 2.3 1.5 1.7 1.5 5.1 2.7 1.4 1.9 2.3 2.1 1.5 2.8 2.5 1.9 5.5 2.6 4.2 1.74 YCR060W 0.7 0.9 0.8 3.3 2.4 1.2 0.7 1.1 1.2 1.7 8.6 1.7 3.3 1.2 1.7 1.04 YDR155C 1.1 1.5 3.2 1.8 0.8 1.5 1.2 1.4 1.3 1.3 3.8 1.4 3.3 1.0 2.5 1.6 1.2 2.5 4.99 YDR258C 1.6 2.3 2.8 1.4 1.3 2.4 3.9 1.9 4.9 13.3 1.7 1.8 5.2 1.5 0.6 1.0 1.3 1.3 0.87 YER103W 0.7 2.1 5.2 2.1 1.1 1.7 1.0 0.9 20.3 9.0 1.8 1.9 9.0 0.9 3.2 1.2 1.4 0.6 2.10 YKL210W 0.5 1.7 2.7 0.7 0.8 1.4 1.0 0.9 3.5 2.9 1.4 1.3 2.9 0.8 1.0 0.9 0.7 1.1 2.29 YLL024C 0.5 1.6 5.3 0.8 0.7 1.0 1.1 0.7 2.8 2.4 1.6 1.0 4.8 0.4 1.3 0.5 0.5 0.6 5.12 YLL026W 1.8 2.9 7.7 1.7 0.9 1.9 2.9 1.4 11.4 6.6 1.7 1.9 8.1 0.8 0.9 1.6 1.7 2.5 2.56 YNL160W 2.1 3.7 10.6 2.0 1.3 5.8 2.4 1.2 3.5 2.7 5.4 1.4 6.0 1.3 0.7 4.0 1.0 1.0 1.77 YNL241C 1.3 2.5 4.3 1.0 0.8 0.9 3.2 0.9 3.4 7.4 3.0 2.0 4.9 1.1 7.0 2.8 1.0 1.0 0.68 YOR027W 0.7 2.4 4.4 0.8 1.0 1.6 1.3 0.9 3.5 4.0 1.3 1.3 5.1 0.8 1.4 0.6 0.9 0.8 1.52 YPL240C 0.7 1.4 2.4 0.9 1.3 1.2 1.4 1.2 3.5 2.6 1.0 0.8 2.9 0.7 1.2 0.7 0.8 1.0 4.83 YDR293C 0.9 0.9 1.2 1.4 0.6 0.9 0.9 0.6 1.2 1.2 1.1 0.9 2.3 0.8 1.7 1.6 1.4 1.3 1.12 YDR436W 0.9 0.9 1.1 1.4 0.7 1.1 1.2 0.9 3.5 1.1 2.0 0.9 2.7 1.2 0.8 1.4 0.9 1.2 0.53 YDR519W 1.3 3.2 1.7 1.6 0.7 1.3 1.9 1.4 0.5 1.2 1.2 1.7 2.5 1.3 2.0 1.5 1.8 2.4 2.01 YEL030W 0.7 0.9 1.9 1.1 0.4 0.6 0.9 0.7 2.3 2.5 1.7 0.9 2.7 0.7 0.8 0.8 0.9 0.6 1.28 YER125W 0.6 1.1 1.5 0.9 1.4 0.7 0.8 0.7 0.6 1.2 1.0 0.7 1.9 0.7 0.8 1.0 1.0 1.0 1.48 YFL016C 0.8 1.0 1.6 0.9 1.3 1.3 1.4 0.7 6.4 2.9 1.2 1.0 2.8 0.8 0.8 0.6 1.2 0.9 1.25 YFR052W 1.1 1.6 1.3 1.5 1.4 3.2 2.2 1.5 3.7 3.0 0.9 1.8 3.8 3.3 1.4 2.7 1.2 1.9 1.62 YHR057C 1.1 1.2 0.7 0.9 1.3 1.3 1.3 1.0 2.6 1.2 1.6 1.1 1.9 1.9 1.2 2.2 1.6 1.3 1.07 YIR037W 1.4 2.2 2.0 2.3 0.6 2.7 1.8 1.3 6.2 3.8 3.0 1.3 2.4 2.3 1.0 4.0 1.7 2.9 1.97 YIR038C 1.3 3.5 4.6 2.0 0.7 2.5 2.0 1.3 4.6 4.5 3.4 1.1 2.5 2.5 1.2 6.0 2.8 2.0 1.11 YJR045C 0.5 1.9 3.9 0.5 1.2 1.0 0.8 3.2 3.0 1.4 1.0 2.3 0.5 2.3 0.8 0.7 0.9 3.78 YLL039C 1.1 1.0 1.7 1.2 0.9 1.5 1.1 1.1 3.4 1.5 1.1 1.0 2.2 1.4 3.0 1.1 1.6 2.1 3.60 YLR259C 0.7 1.0 3.1 1.6 1.1 0.9 1.8 0.8 1.8 2.6 3.0 0.7 2.5 0.8 2.1 1.3 0.8 1.0 2.09 YML070W 0.9 1.7 2.5 1.9 1.4 2.2 3.1 1.3 4.5 3.9 1.5 1.3 3.3 1.3 0.9 2.6 1.2 1.3 1.03 YPL106C 0.6 1.7 2.4 1.1 1.2 1.6 1.1 1.2 4.9 1.8 1.3 1.1 3.1 0.9 1.1 0.5 0.5 0.5 3.34 YPR026W 0.9 1.2 5.0 1.3 0.8 1.3 1.0 0.9 3.1 1.6 1.2 2.3 1.5 3.1 2.5 0.9 1.3 0.26 YDR077W 1.2 1.0 3.5 2.1 0.8 1.0 0.7 0.8 0.7 0.7 6.8 0.8 1.0 0.3 6.1 1.0 1.4 1.1 4.77 YKL163W 1.1 1.4 3.4 1.9 0.6 1.1 0.9 0.8 0.7 1.6 1.3 0.9 1.5 0.5 16.8 3.0 0.8 1.0 2.01 YLR109W 0.8 2.9 6.0 0.9 1.3 2.1 2.6 0.9 2.4 2.7 1.5 1.6 3.2 2.3 3.9 1.8 1.1 1.2 3.86 YOR208W 1.3 1.0 1.2 2.9 1.4 1.8 1.1 1.0 1.5 2.0 1.2 1.2 1.5 1.3 4.4 1.9 1.6 1.6 0.56 YDR098C 0.8 1.4 1.0 0.8 1.5 1.1 1.5 1.2 3.7 1.5 1.4 1.3 1.2 1.5 2.2 0.8 1.0 1.2 1.59 YHR030C 2.1 0.8 0.6 2.9 1.8 0.9 1.8 1.5 0.6 2.5 1.5 0.7 1.0 1.1 3.4 1.4 2.0 1.8 1.05 YJL159W 1.0 1.3 2.8 1.1 1.0 1.8 0.9 0.8 0.5 1.2 1.2 1.0 1.7 0.6 5.3 1.0 1.4 0.9 2.45 YMR173W 1.5 3.6 3.0 0.9 1.1 5.0 2.4 2.3 2.7 8.2 3.2 1.4 2.0 2.3 2.5 1.2 1.9 1.8 1.37 YCR021C 5.2 1.4 4.2 8.6 0.9 2.2 0.9 0.8 2.2 1.0 0.6 0.5 0.9 1.6 0.5 0.6 0.7 0.8 1.36 YDL022W 0.9 2.6 6.9 1.5 0.7 2.1 1.5 0.8 1.2 1.8 2.8 1.2 1.5 0.8 0.9 1.1 1.0 1.4 1.79 YDR033W 1.1 1.3 4.6 1.5 1.1 6.7 0.8 1.0 0.3 1.0 0.7 1.0 0.7 1.0 0.8 1.0 0.7 1.0 5.78 YFL020C 1.0 1.1 1.9 1.2 1.1 2.0 1.4 0.7 1.3 1.4 1.2 1.3 1.4 1.0 1.4 0.9 1.5 0.9 0.70 YGL073W 1.0 2.1 0.9 1.0 1.7 1.9 1.3 0.8 1.9 2.4 0.8 0.8 1.5 1.2 0.9 1.1 2.5 1.2 0.66 YIL033C 0.8 1.3 3.3 1.3 0.7 2.0 1.1 0.7 2.4 1.3 1.8 1.1 2.5 0.7 1.0 2.0 1.0 1.2 1.18 YMR021C 1.0 0.7 0.9 1.1 1.6 2.2 2.5 1.3 0.6 1.3 0.9 0.8 1.4 1.3 1.0 2.0 3.3 3.4 1.14 YBR126C 0.8 1.9 5.6 1.2 0.7 2.9 2.3 0.6 1.7 1.1 1.3 2.1 0.7 1.0 1.7 1.5 1.3 1.96 YBR067C 1.6 2.5 2.8 0.9 1.1 1.1 1.1 1.1 1.7 1.0 3.1 1.0 0.9 0.7 3.3 2.5 0.5 0.4 1.76 YDR513W 2.2 2.5 2.3 2.6 0.9 2.1 1.6 1.6 4.6 3.1 2.0 0.9 1.8 2.0 1.3 3.8 1.3 3.2 3.10 YGR088W 1.3 1.2 7.7 2.4 1.0 1.3 0.8 0.8 1.5 3.2 3.9 1.1 1.2 1.3 0.7 5.6 0.9 2.0 0.75 YHR104W 1.0 4.1 15.7 1.9 1.1 1.2 1.5 1.1 4.8 2.3 2.6 1.0 1.2 1.5 1.6 1.3 1.9 1.9 1.57 YKL161C 4.2 0.8 0.9 2.2 1.4 2.0 2.0 1.9 1.4 1.7 3.1 0.9 1.3 1.4 1.3 1.1 1.4 1.9 0.45 YPL223C 4.8 20.0 1.2 5.1 0.9 1.5 1.1 1.2 29.4 16.5 1.8 0.9 2.3 2.5 1.5 19.0 1.0 1.3 0.31 YBR054W 1.9 1.8 5.4 1.7 0.8 1.1 0.6 2.1 0.4 1.2 1.8 0.7 1.5 1.0 0.6 0.4 0.7 0.7 3.02 YAL015C 1.2 1.1 1.7 1.9 1.1 0.7 1.2 1.1 4.0 2.7 1.4 1.0 1.2 1.6 0.7 2.0 1.1 1.2 0.61 YDL025C 1.7 5.0 3.5 1.5 0.6 0.6 1.0 1.1 3.6 4.5 1.5 0.9 1.2 1.7 1.0 1.7 1.0 1.4 0.56 YML007W 0.9 0.8 0.9 1.3 1.0 0.5 1.1 1.9 2.1 2.5 1.3 1.1 1.7 1.2 1.0 1.4 1.0 1.4 1.54 YER042W 3.0 2.2 3.1 1.0 1.1 1.6 1.1 1.7 6.8 2.1 1.8 1.1 1.4 5.2 1.0 1.9 0.7 1.1 1.80 YOL064C 1.4 2.1 1.1 0.6 0.9 1.4 1.2 1.0 8.7 2.7 1.0 0.9 2.0 0.9 1.0 1.7 1.2 1.3 1.32 YGL181W 0.9 0.9 1.2 1.1 1.1 1.9 1.3 1.2 2.7 2.3 1.2 1.0 2.8 1.0 1.5 1.3 1.0 1.3 0.98 YJL128C 0.8 1.4 0.4 0.8 1.2 1.3 1.8 0.9 2.0 1.7 0.6 1.0 1.7 0.8 1.2 0.9 1.0 1.0 0.42 YJL165C 1.0 0.8 1.3 1.6 1.1 0.5 0.8 0.7 2.8 1.0 1.7 0.9 1.5 0.9 1.0 1.5 1.3 1.8 0.87 YJR090C 0.8 1.0 0.6 0.8 1.2 1.2 0.8 0.8 1.9 1.2 0.4 0.8 2.2 1.0 1.6 0.8 1.1 1.0 0.60 YMR186W 0.6 1.4 2.0 0.9 1.3 1.3 1.2 0.8 2.6 1.3 1.1 1.0 2.4 0.6 1.3 0.6 0.7 1.1 6.64 YNL064C 0.9 1.8 1.8 1.1 0.9 0.8 0.6 1.4 2.4 1.8 0.9 0.8 1.1 0.8 0.7 0.3 0.7 0.7 3.79 YOR008C 0.7 0.8 1.4 1.1 1.4 1.1 0.8 0.8 1.9 1.0 1.0 0.7 0.9 0.9 0.9 1.2 0.8 1.3 1.75 YPL194W 0.9 1.4 0.4 1.1 1.3 1.1 1.5 1.3 9.6 3.1 0.9 0.9 1.4 1.1 1.4 0.9 1.0 0.8 0.22 YBL093C 1.0 2.0 0.4 1.4 1.0 0.8 1.3 1.6 0.7 1.1 1.3 1.1 2.1 1.0 0.5 0.9 1.4 1.3 1.47 YKR053C 0.9 2.0 1.0 1.2 1.0 1.1 1.7 0.9 0.8 1.8 0.5 0.7 0.7 1.3 0.3 0.9 2.8 2.4 0.35 YJL158C 0.9 0.6 2.8 1.5 1.4 0.5 0.4 0.7 0.2 0.5 1.9 1.1 0.4 0.5 1.7 0.6 1.4 1.4 3.48 YER057C 1.2 2.0 3.0 1.8 0.8 1.6 1.4 1.0 0.6 1.4 1.8 1.5 1.0 1.4 1.7 2.8 1.1 1.8 2.03 YHL046C 1.1 1.7 2.1 1.3 0.9 0.8 1.3 1.0 1.0 2.1 0.4 1.1 1.4 1.4 1.0 1.4 0.9 0.9 0.55 YIL011W 0.7 0.5 3.9 0.6 1.1 0.7 0.6 0.7 0.0 0.5 2.5 0.6 0.5 0.5 0.9 1.0 0.8 0.8 0.57 YKL164C 0.6 1.1 2.5 0.9 1.1 1.4 0.8 0.8 0.4 0.7 1.0 0.8 0.9 0.3 1.2 1.1 0.8 0.8 2.75 YNR076W 1.3 1.3 2.5 1.0 1.2 1.2 1.2 1.0 1.3 2.5 1.4 0.7 0.9 0.8 1.1 0.8 1.5 0.8 0.42 YOL161C 1.2 1.1 2.4 1.4 0.9 1.0 0.9 0.8 0.7 2.0 1.5 1.3 1.2 0.9 1.1 1.6 1.1 1.0 0.89 YOR009W 0.9 0.8 3.2 0.7 0.8 0.9 0.6 0.7 0.4 0.5 1.4 0.4 0.4 0.7 0.6 0.8 0.9 0.8 0.36 YOR010C 0.7 0.7 3.2 0.6 1.2 0.5 0.4 0.5 0.6 0.7 1.2 0.5 0.5 0.4 0.6 1.1 1.4 0.6 0.61 YPL059W 1.2 0.9 2.6 1.3 1.2 1.3 0.7 1.4 2.0 1.3 1.6 0.8 0.7 1.3 1.0 2.1 1.8 1.3 1.35 YBR044C 0.8 1.4 0.7 1.9 1.4 1.0 1.5 1.1 0.8 1.2 1.1 0.8 1.2 0.9 0.9 1.4 0.9 1.3 0.57 YEL039C 1.1 0.7 1.3 5.1 0.9 1.5 0.6 1.1 1.2 1.2 1.7 0.6 0.5 1.4 0.4 3.5 0.7 1.1 1.59 YGL115W 0.9 0.6 1.2 2.0 1.2 1.2 1.4 1.0 1.2 1.2 1.0 0.9 0.7 1.2 0.7 1.7 0.8 1.2 2.46 YLR006C 0.7 0.7 0.9 6.2 1.6 0.9 1.1 0.9 1.1 1.1 1.5 0.7 0.8 1.0 0.9 0.8 1.6 1.0 0.40 YPR005C 1.3 0.8 1.5 3.8 1.0 0.8 1.2 1.2 2.8 2.0 0.4 0.6 0.7 1.3 2.7 0.8 1.0 1.1 0.24 YHL028W 0.7 0.8 1.4 0.5 1.1 1.8 2.1 0.4 0.2 0.4 0.7 1.5 2.1 1.3 0.6 2.6 1.6 2.5 0.62 YCR083W 1.1 2.8 1.5 1.8 1.6 2.4 1.8 1.5 1.8 1.8 1.8 1.1 1.8 2.4 1.0 3.1 1.3 1.3 0.98 YPL140C 0.9 1.3 0.9 1.0 0.8 0.3 1.4 1.1 0.9 0.9 0.8 0.8 0.9 1.1 0.7 1.8 0.9 1.4 0.46

TABLE 7 Metabolism protein genes The level of expressed mRNA in the presence of chemical substance/ The level of expressed mRNA in the absence of chemical substance Inten- yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) sity YCR107W 12.0 2.6 1.8 1.6 0.7 1.5 1.5 15.6 196.6 34.0 23.0 0.9 4.0 8.3 4.8 3.1 1.3 1.1 0.59 YDL243C 14.4 2.7 2.4 1.0 1.1 2.2 1.6 11.8 64.2 29.6 19.6 1.1 4.1 12.0 4.2 3.0 1.8 1.5 0.76 YFL014W 3.4 7.2 5.7 11.0 1.0 9.3 5.5 3.4 13.1 5.8 5.0 4.3 15.2 7.3 6.3 14.2 1.5 8.8 2.14 YFL056C 19.0 2.3 2.3 1.5 0.9 0.6 1.4 18.5 162.3 31.3 68.3 1.0 4.7 7.8 5.0 3.4 1.0 1.1 0.55 YFL057C 20.9 5.8 1.5 1.8 0.9 1.2 1.8 18.0 51.8 46.1 27.7 1.0 4.1 23.4 3.1 3.9 1.6 1.3 0.71 YJR155W 10.6 3.7 1.4 2.5 0.7 1.4 1.7 10.6 38.2 18.8 15.4 1.0 5.7 9.4 2.6 5.6 1.3 1.4 0.64 YNL331C 8.6 3.6 1.3 1.0 1.6 1.8 1.9 13.1 42.6 36.3 21.8 0.9 3.1 7.5 2.3 4.0 1.7 1.3 0.58 YNL332W 1.1 1.5 1.1 2.0 1.6 1.1 2.1 1.5 3.3 2.1 2.6 1.2 2.1 3.0 5.4 2.2 1.0 1.0 0.24 YOL165C 10.1 4.5 1.8 0.9 0.9 1.7 1.4 17.8 46.9 23.3 17.6 0.8 3.7 9.1 3.0 1.8 1.6 1.0 0.69 YPR167C 5.3 5.8 1.9 0.8 1.4 2.6 1.2 5.5 76.6 9.0 1.9 1.3 1.9 4.2 0.9 0.9 1.7 1.4 0.54 YBR256C 3.0 1.4 0.6 1.3 1.6 2.0 2.1 2.3 18.1 6.8 3.2 1.7 3.5 5.6 1.6 3.0 2.6 3.3 1.97 YBR296C 7.0 11.2 2.2 2.5 1.4 1.4 0.2 1.1 0.4 1.8 1.5 1.6 2.0 2.3 1.7 0.3 3.8 4.0 0.54 YDL021W 4.8 1.7 2.4 3.7 1.7 6.5 5.9 2.7 2.5 7.4 4.7 2.4 5.3 3.7 0.7 7.3 1.9 3.2 0.47 YFL061W 1.5 1.4 2.1 3.0 1.0 0.5 1.2 1.2 3.2 9.9 1.1 0.9 1.2 6.0 2.1 1.0 1.2 0.9 0.31 YGR043C 2.5 4.7 3.2 7.9 0.9 16.3 6.5 2.6 10.9 8.4 3.6 3.3 6.9 4.1 3.0 13.7 1.6 4.8 0.66 YHR112C 1.8 3.1 0.7 1.4 1.3 2.9 3.4 1.7 10.5 4.4 1.5 1.9 3.9 2.4 2.0 2.7 1.6 1.8 0.55 YIR030C 1.4 1.0 0.9 1.3 0.9 0.5 1.2 1.4 5.4 2.1 1.4 0.9 1.3 2.9 0.7 0.8 0.9 1.0 0.42 YJR010W 9.1 7.3 4.9 0.8 1.1 2.5 1.4 3.1 30.0 11.1 2.9 1.4 3.2 5.4 1.7 1.7 1.2 1.0 0.56 YKL001C 6.8 21.4 5.6 1.8 0.8 0.9 1.1 3.4 10.3 3.4 2.6 2.1 1.6 6.2 1.1 1.8 2.7 1.7 0.91 YKR097W 1.3 2.4 1.3 3.3 1.1 1.7 3.7 2.5 1.9 3.3 0.8 1.8 17.5 2.1 2.5 2.2 1.1 1.5 0.16 YLR303W 7.3 9.8 12.1 1.1 1.1 3.0 3.6 5.3 18.6 5.6 9.8 4.3 9.9 3.8 5.8 3.4 1.5 1.4 1.42 YNL274C 1.4 18.7 2.6 1.9 0.7 4.2 2.0 2.3 6.3 5.3 4.0 1.1 2.3 3.3 2.5 6.4 1.4 2.6 0.85 YOL151W 6.7 3.8 9.1 1.3 1.3 8.4 4.4 6.7 22.8 17.0 9.0 4.6 16.9 4.0 2.8 3.7 4.0 5.6 1.12 YOR226C 1.3 2.2 1.7 1.1 1.3 1.2 1.2 1.2 1.3 5.9 1.5 0.6 0.9 2.7 1.0 0.7 1.0 0.7 0.58 YJL153C 1.3 1.7 1.7 17.6 0.7 0.8 2.3 1.3 3.9 2.5 0.7 10.2 38.0 1.4 37.0 1.0 6.5 1.8 0.27 YOR153W 1.6 0.9 5.1 1.1 1.0 7.4 2.6 0.5 3.2 1.2 1.0 4.0 11.8 0.3 3.6 1.6 2.5 3.1 1.91 YPL088W 3.3 1.3 0.6 2.5 1.5 7.1 3.7 1.9 0.6 2.8 1.1 3.6 4.8 1.6 3.2 4.3 9.1 8.3 0.69 YDL124W 2.1 8.5 5.7 1.7 0.7 3.4 2.9 2.1 3.3 5.3 3.4 2.4 6.0 1.6 3.4 3.6 2.2 2.6 2.43 YDL174C 0.9 1.8 0.9 1.3 0.5 1.7 3.6 0.8 0.5 1.7 0.9 2.8 5.9 1.1 0.6 5.1 2.2 4.0 0.63 YGL156W 1.3 2.5 1.8 2.2 1.4 2.1 2.1 1.4 5.6 2.4 2.1 2.6 6.0 1.6 3.0 4.1 1.4 1.9 0.29 YGR157W 1.0 0.9 5.2 0.8 1.2 1.0 0.8 0.7 3.3 2.0 1.0 1.8 4.8 0.7 4.6 1.0 0.8 1.3 2.10 YHR043C 1.3 1.8 1.2 1.7 0.9 2.2 2.9 3.0 1.2 1.0 1.6 2.2 2.7 1.3 2.1 2.2 1.4 1.7 1.38 YHR044C 1.3 1.3 1.7 1.5 1.2 3.3 2.6 2.0 1.1 1.1 1.7 2.3 4.3 1.3 1.5 2.4 1.3 1.4 1.12 YJR073C 1.1 2.4 2.7 2.7 0.6 2.2 2.9 1.0 6.8 2.8 2.8 4.1 10.0 2.3 28.9 3.7 2.9 2.6 0.99 YOR303W 1.1 2.2 0.5 1.0 1.2 1.8 1.2 1.6 0.9 5.2 0.9 1.9 3.3 1.6 4.1 1.2 1.2 0.8 1.47 YBR294W 6.3 12.0 0.9 2.6 1.4 1.2 1.1 1.0 5.2 5.2 1.2 1.0 3.1 1.3 1.0 0.9 1.0 0.9 0.18 YCL043C 0.6 3.7 2.5 0.7 0.9 1.3 1.0 0.8 1.6 1.2 1.7 1.5 4.1 0.6 5.7 0.8 0.9 1.0 2.37 YCL050C 1.0 1.1 1.9 0.7 1.4 1.2 1.2 1.2 3.0 2.9 1.3 1.2 2.8 1.2 0.8 0.7 1.0 1.0 2.20 YCR012W 1.1 1.5 5.1 1.2 1.1 2.5 1.4 0.8 1.4 1.5 1.8 1.2 4.1 0.9 1.4 1.4 0.8 1.3 4.48 YDR158W 1.1 0.5 1.8 0.8 1.3 1.0 0.8 1.2 1.1 1.7 1.6 1.0 2.6 0.9 1.0 0.6 1.0 0.9 3.54 YDR204W 0.9 2.3 3.0 1.4 1.0 2.2 2.2 1.1 5.7 3.7 2.2 1.2 2.9 1.1 0.6 2.8 1.1 1.7 0.62 YDR313C 1.2 1.2 1.2 1.4 1.3 1.4 1.5 1.2 4.7 2.6 1.5 1.2 2.3 1.3 0.8 2.9 1.1 1.3 0.84 YDR368W 2.0 2.2 2.2 1.8 1.0 3.0 2.1 1.7 3.8 3.8 1.8 1.4 2.6 2.0 1.2 2.3 1.1 2.0 1.70 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1.5 1.5 2.6 1.4 2.0 3.40 YGR055W 2.5 5.7 12.0 0.7 1.3 1.1 0.6 1.1 5.0 2.4 1.5 0.9 1.9 1.2 2.1 0.6 0.7 0.7 1.42 YGR194C 0.9 1.0 1.3 2.1 0.8 1.9 2.2 1.2 2.4 2.1 0.7 0.8 2.2 1.0 0.6 2.6 1.1 2.0 0.63 YGR256W 1.2 1.5 2.3 0.8 0.9 6.2 1.4 2.2 3.4 2.5 2.7 1.5 3.9 1.1 2.7 5.3 1.1 0.8 0.94 YHR111W 1.4 1.3 0.8 1.9 1.5 1.3 1.6 1.3 4.5 4.2 1.9 0.9 2.2 1.7 1.1 1.3 1.1 1.2 0.44 YHR174W 1.1 1.4 3.3 1.2 1.3 1.5 1.6 1.2 1.0 1.5 1.4 1.5 3.6 0.6 2.0 1.1 1.0 1.2 7.34 YHR176W 1.8 2.0 1.1 1.4 1.0 2.3 1.4 1.3 6.3 6.4 1.2 1.2 1.9 1.3 1.5 1.8 1.4 1.6 0.27 YIL045W 1.7 1.4 1.9 2.2 1.3 1.7 1.6 1.1 2.1 3.2 1.2 1.5 2.0 1.6 0.6 2.9 1.1 1.8 0.37 YIL107C 1.5 0.8 1.1 1.5 0.8 1.0 1.6 1.3 3.5 3.5 0.9 1.1 1.9 1.6 1.0 2.7 1.2 2.0 0.58 YIL155C 1.0 0.7 1.4 3.7 1.3 1.4 2.2 1.0 2.5 2.9 1.3 1.4 2.0 1.3 1.4 3.8 1.1 1.4 0.51 YIR034C 1.2 1.1 2.5 0.6 1.1 1.3 0.8 1.7 3.2 3.5 3.0 1.4 2.6 1.2 1.9 1.3 1.0 1.0 0.92 YIR036C 1.0 1.7 2.6 1.8 0.9 0.7 1.0 1.0 3.3 1.9 2.8 1.2 1.9 1.2 1.1 4.0 1.5 1.3 0.64 YJL031C 1.6 1.2 0.5 1.3 1.7 1.6 2.3 1.8 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YPL135W 0.9 1.2 2.5 1.2 1.6 1.3 1.2 1.0 0.5 2.8 1.3 1.1 1.2 1.1 1.5 1.2 1.5 1.7 1.50 YCR010C 1.6 1.6 1.6 4.2 1.7 1.3 1.3 0.8 0.9 4.7 1.1 0.8 1.0 1.2 1.2 2.8 1.9 1.5 0.26 YBR003W 0.9 0.8 1.0 1.9 0.7 1.2 1.1 0.9 1.0 1.3 1.3 0.8 1.2 0.8 0.7 2.0 1.1 1.3 1.06 YBR020W 1.0 0.5 1.9 1.9 1.0 0.8 0.7 1.0 −0.4 1.1 1.0 0.8 1.1 1.0 1.3 0.7 0.8 0.9 0.27 YDR123C 1.2 0.8 0.4 2.1 1.6 0.7 0.9 1.3 0.5 0.6 0.6 0.5 0.9 0.7 1.2 0.8 1.3 1.0 0.30 YDR277C 1.6 1.2 1.0 3.0 0.8 1.1 1.2 1.7 0.2 0.9 1.2 0.9 1.2 1.3 0.4 2.3 1.2 1.7 0.89 YDR408C 1.0 1.0 1.4 4.1 0.9 0.9 0.8 0.7 0.3 0.5 1.7 0.6 0.5 0.9 1.0 1.0 1.1 1.1 2.16 YDR483W 1.1 1.0 1.3 2.0 0.7 1.5 0.8 1.0 0.4 1.1 1.4 0.8 1.3 0.8 1.5 1.2 1.2 1.4 3.24 YGL115W 0.9 0.6 1.2 2.0 1.2 1.2 1.4 1.0 1.2 1.2 1.0 0.9 0.7 1.2 0.7 1.7 0.8 1.2 2.46 YGR096W 1.5 1.0 1.1 4.6 1.2 1.7 0.9 1.0 0.8 0.8 0.8 0.8 1.1 1.2 0.9 0.8 0.8 1.0 0.49 YGR288W 0.9 0.5 1.0 2.6 0.8 1.4 1.0 1.6 2.6 1.3 0.9 1.3 1.1 0.8 1.7 1.2 1.3 0.41 YHR210C 1.3 1.0 0.6 5.2 1.8 0.7 1.9 1.3 −0.1 0.9 1.5 0.5 0.4 1.0 0.5 1.5 1.4 1.2 0.33 YIL006W 1.0 1.1 1.4 2.9 0.8 0.3 0.8 0.6 0.9 1.1 1.0 0.9 0.8 1.0 1.5 1.7 0.8 0.9 0.28 YKR034W 0.9 1.5 1.1 4.7 0.9 0.9 0.7 1.5 0.5 0.6 0.0 0.7 1.2 1.1 1.7 0.6 0.8 1.0 0.26 YLR006C 0.7 0.7 0.9 6.2 1.6 0.9 1.1 0.9 1.1 1.1 1.5 0.7 0.8 1.0 0.9 0.8 1.6 1.0 0.40 YNL025C 0.9 1.4 1.4 12.8 0.7 0.5 1.2 1.0 1.1 1.8 1.1 0.8 1.3 1.2 1.4 2.9 0.7 1.3 0.37 YOL116W 1.1 1.0 0.9 2.8 1.7 0.7 1.5 1.3 0.6 1.8 1.0 0.6 0.8 0.9 0.7 1.9 1.1 1.4 0.47 YOR103C 1.1 0.8 1.3 1.8 1.5 1.0 1.2 1.0 0.8 0.9 1.0 1.2 0.8 1.2 1.4 1.3 1.1 1.5 2.84 YOR251C 1.1 1.0 1.3 1.8 0.8 0.9 1.0 1.1 0.8 0.8 1.0 0.9 1.0 1.1 0.6 1.2 0.9 1.3 1.34 YOR348C 1.1 0.7 1.2 2.0 0.9 0.7 0.8 0.8 0.5 0.4 1.1 0.7 1.1 1.2 1.6 1.7 0.9 0.9 0.18 YPL148C 1.2 0.8 0.9 2.3 1.1 0.6 1.0 0.9 0.7 1.5 3.5 0.7 0.6 1.6 0.6 1.6 1.0 1.1 0.48 YGL205W 0.9 0.9 0.7 0.8 1.1 1.6 0.8 1.2 0.5 0.6 0.4 1.1 1.0 1.0 2.0 4.1 3.9 9.1 0.24 YNL192W 1.1 1.2 1.5 1.6 0.9 0.6 1.0 0.8 0.6 1.8 1.1 1.1 2.7 0.7 2.1 0.8 2.3 2.8 1.31 YOL108C 1.4 1.5 0.4 1.9 2.1 0.9 1.1 1.3 1.6 0.9 1.1 1.0 1.3 0.9 1.5 1.8 1.5 2.7 0.87 YPR165W 1.3 0.7 1.6 1.0 1.5 1.8 1.0 1.0 0.9 0.7 1.0 0.8 1.0 1.0 0.9 1.0 2.3 2.7 3.64 YDR073W 1.7 0.9 0.7 1.4 1.2 1.3 1.2 1.3 0.5 1.2 1.0 0.8 0.6 1.2 0.8 1.6 1.8 2.3 1.27 YER015W 0.7 0.9 1.1 1.5 1.3 0.9 1.2 1.1 0.4 0.9 1.0 0.9 0.8 1.1 0.8 3.0 1.6 2.6 0.41 YJL167W 0.9 1.4 1.4 1.1 0.7 1.3 1.5 1.5 0.9 0.9 1.2 1.3 0.9 0.9 1.6 1.4 1.4 2.1 2.94 YJL216C 0.8 4.7 2.2 0.9 0.8 1.5 1.9 1.5 1.3 1.1 1.0 1.1 1.1 1.2 1.5 1.2 2.0 0.25 YKR009C 1.0 1.2 1.5 0.9 1.0 1.8 1.0 0.9 2.4 2.1 1.2 1.0 1.8 1.0 1.0 4.6 1.9 2.5 0.27 YOR180C 0.8 1.1 1.0 1.0 1.0 0.7 0.8 0.9 0.3 0.4 0.6 0.8 0.9 1.0 1.1 2.4 0.9 2.3 0.55 YBR036C 0.8 1.7 1.8 1.2 1.2 1.3 1.3 0.7 1.0 1.0 1.5 1.0 1.9 0.8 1.5 1.6 2.1 1.8 2.05 YDR297W 1.5 0.8 0.8 1.1 0.9 1.4 0.6 1.5 0.3 0.7 1.4 1.0 0.8 0.9 1.4 1.4 1.9 1.9 1.73 YDR387C 0.8 0.9 1.2 2.2 0.9 1.2 1.3 0.7 1.4 2.0 2.0 0.9 1.3 0.9 1.4 2.7 1.2 1.1 0.86 YOL096C 1.1 1.0 1.2 1.6 1.2 1.3 1.7 1.0 1.3 1.4 1.2 1.2 1.4 1.4 1.0 2.3 1.2 1.2 0.64 YPR184W 1.2 1.4 5.7 2.2 0.9 1.5 1.3 0.7 1.9 3.2 3.6 1.4 2.5 1.3 1.5 3.1 1.0 1.7 0.37 YBR298C 1.1 1.0 1.6 2.3 1.4 0.4 1.7 0.5 0.3 1.1 1.5 1.1 0.8 0.9 0.2 2.1 0.9 0.8 0.88 YDL078C 0.7 1.1 1.2 0.8 1.3 1.1 1.7 1.0 1.1 1.0 1.7 0.8 1.0 0.8 0.5 2.2 1.1 2.0 1.65 YDL215C 1.0 1.5 1.0 1.6 1.5 0.9 1.9 1.1 1.7 2.4 0.8 0.8 1.5 1.0 1.1 2.2 1.1 1.6 0.91 YGL035C 0.7 1.4 4.3 1.4 1.1 0.6 1.2 1.3 0.9 1.5 1.3 0.9 1.1 1.1 1.0 2.3 0.9 1.2 0.61 YGR287C 1.3 1.0 1.3 1.5 0.8 0.8 2.2 1.3 2.6 4.2 1.5 1.1 1.7 1.1 2.3 3.0 1.0 1.1 0.38 YJL070C 1.3 0.9 1.1 1.2 1.3 2.0 1.4 1.1 1.0 1.1 1.3 1.0 1.8 1.3 3.5 2.2 1.1 1.2 0.34 YLR351C 1.0 1.4 1.3 1.5 1.3 1.4 1.4 1.2 0.8 1.2 1.1 0.9 0.9 1.4 1.2 2.0 1.3 1.8 1.75 YLR375W 0.9 1.5 0.9 0.9 1.0 1.3 0.9 1.0 1.6 1.2 1.6 0.9 1.6 0.9 1.3 2.2 1.0 1.0 1.05 YMR267W 0.8 1.8 0.7 0.9 1.0 1.4 1.2 1.5 0.4 0.8 1.0 0.8 0.7 1.0 0.9 2.6 0.9 1.3 0.94 YMR278W 0.7 1.7 1.4 1.0 1.2 1.3 1.8 1.1 1.4 1.7 1.1 1.0 2.5 0.8 1.8 2.5 1.0 1.5 0.62 YMR293C 0.9 1.5 1.6 2.2 0.6 0.5 1.2 1.0 0.7 1.3 0.4 0.9 0.8 1.3 0.7 2.2 0.8 1.0 0.37 YNR072W 1.1 1.5 0.5 0.7 1.0 0.9 1.5 0.9 0.7 1.8 1.4 1.0 1.5 1.0 1.8 2.1 1.3 1.0 0.26 YOR363C 0.8 2.0 0.9 1.3 0.7 1.2 0.7 1.1 1.2 1.6 1.2 0.9 1.3 0.9 1.1 2.1 1.3 1.8 0.40

TABLE 8 Detoxification protein genes The level of expressed mRNA in the presence of chemical substance/ The level of expressed mRNA in the absence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YDR453C 1.1 2.7 4.4 3.0 0.7 1.7 1.0 1.3 4.5 6.1 2.3 0.9 1.4 3.8 2.3 5.6 1.0 1.5 1.53 YLL060C 12.5 4.2 2.3 2.6 0.9 1.4 2.0 5.8 13.0 23.2 14.1 1.1 1.8 10.6 1.5 3.6 1.9 2.3 0.57 YBL064C 2.6 2.8 3.9 1.7 0.8 5.2 2.5 2.4 4.5 3.8 2.9 1.7 4.1 5.0 1.3 5.0 1.2 2.3 1.67 YBR008C 3.0 2.4 4.9 0.7 0.9 1.0 0.9 2.8 54.6 21.1 9.4 0.8 2.0 4.1 0.8 3.1 2.0 1.2 0.37 YOR153W 1.6 0.9 5.1 1.1 1.0 7.4 2.6 0.5 3.2 1.2 1.0 4.0 11.8 0.3 3.6 1.6 2.5 3.1 1.91 YHL047C 0.6 4.4 1.0 1.0 1.2 8.4 16.8 1.5 1.2 11.9 1.0 2.6 3.8 0.5 1.1 2.3 1.2 1.2 0.74 YCL035C 2.0 2.3 1.5 1.7 1.5 5.1 2.7 1.4 1.9 2.3 2.1 1.5 2.8 2.5 1.9 5.5 2.6 4.2 1.74 YGR197C 1.1 2.4 2.5 1.0 0.7 0.5 1.3 0.8 16.7 3.2 1.1 1.2 2.4 1.5 1.0 1.5 1.7 1.9 0.37 YHR055C 4.4 1.8 0.8 1.2 2.7 1.6 1.1 2.1 3.9 3.3 1.8 1.2 3.0 1.5 0.5 0.8 0.9 0.6 3.96 YNL239W 1.0 2.4 2.4 1.2 1.2 1.8 2.1 1.3 2.5 6.0 1.9 1.5 3.6 1.3 1.7 1.5 1.1 1.4 0.68 YNL241C 1.3 2.5 4.3 1.0 0.8 0.9 3.2 0.9 3.4 7.4 3.0 2.0 4.9 1.1 7.0 2.8 1.0 1.0 0.68 YBR293W 1.9 3.1 1.0 1.8 0.8 0.9 0.9 0.9 5.5 2.4 1.1 1.0 3.0 1.4 3.1 1.6 1.0 0.9 0.94 YDL100C 1.0 1.2 1.1 0.8 1.0 2.1 1.6 1.7 5.4 3.2 2.8 1.5 2.5 1.4 1.0 1.3 1.2 1.4 2.60 YER185W 2.0 3.1 2.1 7.0 1.6 1.2 1.1 1.0 2.9 1.2 1.6 1.1 2.1 1.6 1.7 0.6 2.6 1.1 0.26 YGL013C 0.9 1.2 0.8 0.7 1.1 2.3 0.9 1.4 3.0 1.5 0.9 1.0 2.3 0.8 1.0 0.9 1.1 1.0 0.43 YHR053C 3.5 2.1 0.7 1.1 2.9 1.3 1.2 2.2 4.5 2.9 1.4 1.1 1.9 1.5 0.3 0.7 1.0 0.5 3.99 YIR038C 1.3 3.5 4.6 2.0 0.7 2.5 2.0 1.3 4.6 4.5 3.4 1.1 2.5 2.5 1.2 6.0 2.8 2.0 1.11 YKL026C 2.7 2.0 1.2 4.9 1.0 1.8 2.5 1.8 7.5 3.0 3.0 1.0 2.3 1.8 0.8 6.6 1.6 3.3 0.61 YLL028W 0.6 0.9 4.6 0.5 0.9 1.7 1.0 0.7 1.2 2.3 0.7 1.3 4.1 0.7 3.1 0.6 1.2 1.2 1.02 YOR273C 0.7 1.0 1.7 1.0 1.1 0.4 0.4 0.6 0.6 0.5 1.5 0.8 2.6 0.5 0.8 0.6 3.2 3.1 1.20 YGR138C 1.1 1.6 1.0 1.2 0.8 0.8 0.7 1.0 0.5 1.0 0.7 0.6 0.6 0.9 4.5 0.7 0.7 0.7 1.24 YOR247W 1.7 0.6 3.6 1.4 0.6 0.2 0.5 0.7 0.1 0.4 2.9 0.6 0.3 0.4 7.3 0.2 1.2 0.9 2.23 YPL163C 0.6 0.7 1.4 0.9 0.6 0.6 0.4 0.5 0.1 0.4 0.5 0.9 0.4 0.6 5.3 0.6 1.4 1.4 1.05 YHL040C 1.6 4.4 1.5 0.4 1.1 7.3 4.0 1.5 1.1 11.3 1.7 2.0 2.0 1.1 3.4 1.0 1.4 1.0 0.69 YEL065W 0.3 3.8 1.2 0.4 1.4 2.3 4.3 0.9 0.1 4.9 0.6 1.7 0.8 0.4 2.2 2.6 0.7 0.6 2.10 YIR002C 0.8 1.1 0.5 0.6 1.2 2.2 1.3 1.2 1.7 1.4 0.8 1.3 1.2 1.1 1.1 1.4 1.1 1.2 0.58 YNL259C 1.6 4.5 1.1 1.2 1.1 3.9 3.8 1.5 1.6 2.1 1.6 0.7 1.1 1.4 0.7 1.7 2.6 2.4 1.22 YBR145W 1.5 0.7 2.8 0.9 1.1 11.5 58.8 1.0 0.1 1.1 1.1 1.0 2.0 2.2 1.2 3.6 1.7 2.0 2.17 YLR043C 1.4 1.4 2.0 1.8 2.0 1.4 2.6 1.1 2.8 2.5 1.4 0.8 2.0 2.1 0.5 1.8 1.5 2.2 2.12 YGR209C 1.6 3.1 3.5 1.5 1.9 1.9 1.7 1.6 2.4 6.3 3.1 0.9 1.4 5.0 1.3 1.9 1.3 2.4 3.17 YDL168W 2.3 2.0 2.1 0.9 1.2 1.4 1.1 1.7 8.2 4.7 1.9 0.6 1.3 1.6 1.2 1.1 0.9 0.8 1.08 YDR513W 2.2 2.5 2.3 2.6 0.9 2.1 1.6 1.6 4.6 3.1 2.0 0.9 1.8 2.0 1.3 3.8 1.3 3.2 3.10 YGR088W 1.3 1.2 7.7 2.4 1.0 1.3 0.8 0.8 1.5 3.2 3.9 1.1 1.2 1.3 0.7 5.6 0.9 2.0 0.75 YHR048W 2.5 1.4 1.4 1.7 1.0 0.8 0.8 1.9 4.5 2.7 2.0 0.9 1.1 1.7 0.9 1.4 0.7 0.9 0.26 YJL101C 2.1 1.9 2.1 1.2 1.4 1.0 1.0 1.3 3.1 3.6 2.7 0.7 1.0 1.0 0.5 1.3 0.9 1.0 1.13 YML116W 4.1 1.3 1.5 1.4 1.2 0.9 1.4 2.2 1.4 3.1 4.3 0.5 0.8 2.0 1.9 1.0 1.0 1.0 0.94 YMR038C 1.9 1.7 1.8 0.8 1.5 1.0 1.1 1.9 2.4 2.6 2.7 0.9 1.7 1.1 0.6 1.5 1.2 1.3 1.76 YBR244W 0.6 1.4 2.0 0.9 1.7 1.0 0.6 1.0 1.4 3.0 1.5 0.5 0.4 3.7 0.4 0.7 1.2 1.2 3.42 YCL069W 0.9 15.7 0.9 0.8 0.9 1.4 1.3 1.2 6.9 1.0 0.9 0.8 1.3 1.4 0.9 1.0 1.0 0.25 YKR105C 0.8 0.9 0.9 1.5 1.0 1.2 1.0 1.3 1.0 5.2 0.0 0.8 2.5 1.2 1.5 0.7 0.8 1.0 0.26 YOL158C 0.7 4.0 2.4 0.9 1.2 2.0 1.6 0.7 1.7 6.1 0.7 0.9 1.4 1.0 0.9 1.2 1.4 1.7 1.30 YDR256C 0.8 1.4 0.7 1.3 1.2 0.5 0.6 0.8 5.2 2.0 1.4 0.8 1.1 1.6 1.0 4.3 1.0 2.0 0.30 YGL254W 1.2 1.1 0.8 0.6 1.1 0.7 1.3 1.4 3.1 1.8 1.1 1.2 2.4 1.3 1.1 1.4 0.8 1.2 0.53 YKL064W 0.6 0.9 0.4 0.8 1.2 1.5 1.1 0.9 2.4 1.6 0.7 0.7 1.6 1.1 0.7 1.4 1.3 1.3 0.60 YLL057C 2.2 59.9 1.8 0.9 1.1 1.0 1.6 1.4 121.8 2.9 1.3 0.7 1.4 1.1 1.4 0.9 3.0 1.3 0.19 YPR200C 47.7 1.7 0.8 5.0 1.6 0.8 1.3 1.4 4.7 3.8 2.0 0.4 0.6 2.0 0.7 1.2 1.1 1.0 0.27 YJR104C 1.4 1.8 2.9 1.2 1.5 1.4 1.1 1.5 1.9 2.8 2.6 0.9 0.9 2.0 1.3 2.9 0.9 1.1 3.50 YKR106W 1.3 0.8 2.1 1.4 1.2 1.6 0.9 1.3 10.5 7.4 1.8 0.8 1.4 1.7 2.8 0.9 0.8 0.16 YOR031W 2.6 1.7 1.3 3.4 1.4 0.9 1.3 0.9 0.7 1.3 1.2 0.8 1.8 1.5 1.4 6.2 1.7 2.4 0.52 YHR008C 1.3 6.9 4.8 1.8 0.6 1.0 0.7 0.9 1.7 2.4 2.1 0.7 1.2 1.6 1.7 2.2 0.9 1.0 1.04 YML028W 1.0 2.2 4.4 1.3 1.6 1.2 0.8 0.8 0.8 1.8 1.0 1.6 1.6 2.0 2.2 1.3 1.1 1.5 4.85 YEL027W 1.2 0.6 3.4 1.1 1.0 1.1 0.8 0.9 0.9 1.1 0.9 0.9 0.7 1.4 1.5 1.6 1.0 1.4 4.75 YKR066C 0.9 1.4 5.5 0.7 1.0 0.9 0.5 0.7 0.7 2.4 1.3 0.9 0.6 1.5 0.6 1.3 0.9 1.1 1.25 YDR538W 0.9 1.1 2.4 1.2 1.0 1.0 1.2 1.0 0.3 0.8 0.9 0.7 0.7 0.9 1.0 0.9 1.0 0.9 0.53 YMR015C 0.7 0.7 1.9 0.9 1.7 1.3 0.4 0.7 0.1 0.3 1.0 0.9 0.4 0.8 1.2 1.5 1.0 1.0 2.51 YOR251C 1.1 1.0 1.3 1.8 0.8 0.9 1.0 1.1 0.8 0.8 1.0 0.9 1.0 1.1 0.6 1.2 0.9 1.3 1.34 YLR046C 0.7 1.7 0.9 0.8 1.0 3.8 1.5 0.5 1.0 1.4 0.9 0.8 1.2 1.3 0.8 1.3 5.2 5.4 0.86 YGR224W 0.9 1.2 1.2 1.2 1.4 0.8 0.4 0.6 0.9 0.9 0.8 0.6 0.8 0.9 1.1 1.0 2.8 1.3 0.27 YFL050C 0.7 1.0 1.1 2.2 1.0 0.9 0.8 0.9 0.5 1.6 1.2 0.9 1.2 1.0 1.4 2.3 0.8 1.0 0.36 YCR083W 1.1 2.8 1.5 1.8 1.6 2.4 1.8 1.5 1.8 1.8 1.8 1.1 1.8 2.4 1.0 3.1 1.3 1.3 0.98

TABLE 9 Genes belonging to other category The level of expressed mRNA in the presence of chemical substance/ The level of expressed mRNA in the absence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YKR076W 5.0 2.6 3.5 2.2 1.0 4.7 4.9 6.2 43.4 43.1 18.6 1.5 5.1 14.7 3.2 9.6 1.8 2.7 0.27 YNL335W 1.2 0.7 1.5 2.3 1.5 1.6 1.3 1.7 1.6 5.3 1.1 0.8 0.9 4.6 1.7 1.0 1.2 1.1 0.22 YBR173C 1.1 2.4 3.4 1.6 0.7 1.3 1.6 1.2 6.0 5.1 2.5 1.7 3.8 3.0 15.4 2.1 0.9 1.6 1.15 YFL022C 0.8 0.9 1.5 0.6 0.7 0.9 0.3 0.8 0.5 0.5 1.2 0.6 0.6 3.1 1.1 1.3 0.9 0.8 1.07 YGL158W 1.1 2.8 1.9 12.9 1.0 0.4 1.3 1.3 −0.4 0.9 0.2 1.3 1.0 2.3 2.3 8.2 0.8 1.1 0.18 YHR139C 3.0 4.6 6.8 9.3 1.3 1.9 1.5 1.3 107.2 46.6 3.5 1.6 7.0 2.5 1.9 17.1 1.4 1.3 0.34 YGR213C 5.4 2.9 1.0 6.8 1.2 4.1 7.0 2.0 7.5 6.9 1.6 10.6 30.4 1.0 6.5 5.2 12.8 8.5 0.22 YKL165C 0.5 2.0 1.1 0.6 0.9 0.6 2.1 1.5 0.4 0.4 0.3 2.4 3.2 0.8 2.1 1.2 0.9 1.0 1.08 YBL005W-A 1.0 0.9 0.5 0.9 1.3 1.2 1.4 1.0 0.8 1.5 0.8 1.6 2.9 1.4 0.9 1.1 1.3 1.0 0.48 YBL041W 1.2 1.4 0.9 1.0 1.6 1.7 1.6 1.7 2.8 2.6 1.6 1.6 2.6 2.0 1.3 2.3 1.3 2.0 3.03 YBL078C 2.3 2.7 1.3 2.6 0.7 2.4 3.1 1.6 12.3 15.2 4.6 3.1 5.0 3.6 2.5 4.4 1.8 2.8 0.65 YCL020W 1.1 2.5 0.5 1.1 0.5 1.0 1.5 1.7 0.9 2.4 1.3 1.5 3.0 1.7 2.5 1.3 0.9 1.3 1.46 YDL007W 0.8 1.4 1.3 0.9 1.0 1.1 1.2 1.4 3.8 2.4 1.3 1.1 2.4 1.4 1.4 0.8 0.8 1.5 2.43 YDL097C 0.9 1.7 0.9 1.2 0.8 1.3 1.6 1.5 4.5 2.3 1.5 1.3 4.0 1.4 1.1 1.1 1.0 1.3 2.06 YDL126C 0.5 1.4 2.3 0.7 0.9 1.2 1.5 0.8 2.7 2.0 1.4 1.3 4.3 0.6 1.7 0.7 0.9 0.9 3.24 YER012W 1.4 1.2 1.2 1.0 1.9 2.4 2.4 1.8 6.7 2.7 1.9 1.5 2.9 4.6 1.7 2.2 1.5 1.3 1.84 YFR010W 1.1 1.1 0.8 1.2 0.9 1.3 1.4 1.6 4.3 3.4 1.5 1.2 3.7 1.1 1.5 1.3 0.9 1.4 1.89 YFR024C 0.8 25.0 2.3 1.1 0.7 1.4 3.0 0.9 5.3 4.1 1.9 1.5 2.8 1.2 0.9 1.9 1.0 1.4 1.06 YGL048C 1.0 1.3 0.7 1.3 1.8 1.5 2.0 1.5 2.4 2.1 1.5 1.3 2.5 1.2 1.0 1.6 1.4 2.0 3.07 YGL141W 0.8 1.2 1.1 0.7 1.4 3.0 1.7 0.8 4.5 1.9 0.6 1.4 3.6 1.2 1.5 1.2 1.4 1.2 0.44 YGL180W 1.3 1.3 1.7 0.6 1.2 1.1 2.4 1.2 7.2 3.7 1.3 1.4 2.6 1.0 1.3 1.7 1.0 1.1 0.28 YGR048W 0.7 2.7 1.4 1.3 1.0 1.0 1.9 1.4 4.4 3.1 1.1 1.1 2.5 1.3 0.8 1.1 0.9 1.2 0.93 YGR135W 1.0 1.0 1.0 1.1 1.6 1.5 2.2 1.8 1.5 2.3 1.6 1.2 2.8 2.6 1.5 1.5 1.0 1.9 3.10 YGR201C 1.7 11.9 2.4 2.0 0.8 3.1 2.6 1.6 5.4 3.5 1.6 1.9 8.6 1.6 0.5 14.4 1.4 2.1 0.60 YHL030W 0.5 0.8 1.0 0.7 0.7 1.9 0.9 0.8 2.7 2.5 1.1 1.1 3.8 1.0 2.0 0.5 0.8 0.9 0.66 YHR166C 0.9 1.1 1.0 0.7 1.0 1.8 1.5 1.0 2.6 1.2 0.6 1.7 6.9 1.2 0.9 1.1 1.4 1.5 1.35 YJR069C 0.8 0.8 0.9 0.6 0.9 1.2 1.3 0.9 0.7 0.6 0.9 1.1 3.9 0.6 0.4 0.8 1.0 0.9 1.73 YKL073W 0.6 1.4 0.5 0.6 1.2 0.5 2.1 1.6 1.3 1.1 0.5 1.5 3.3 0.7 1.6 1.0 1.2 1.5 1.29 YKL103C 1.6 4.1 2.5 2.1 0.9 2.7 2.8 1.6 8.3 9.9 2.8 1.3 3.8 2.0 2.1 1.2 1.9 2.2 0.56 YLR080W 1.0 1.4 1.2 1.7 1.1 2.5 2.8 1.3 2.3 1.5 1.9 0.8 3.6 1.2 0.7 3.0 1.6 2.2 0.41 YLR107W 1.2 0.9 0.5 1.2 1.7 2.3 1.6 1.1 1.8 1.2 0.8 1.0 2.9 1.6 1.1 1.6 1.8 2.4 0.94 YLR121C 1.7 1.7 1.1 1.2 1.0 1.6 1.3 2.2 2.0 2.2 1.1 4.0 1.2 10.7 1.5 2.7 1.4 0.30 YLR336C 0.6 0.8 0.7 0.4 0.9 0.8 1.8 1.0 −0.3 0.5 0.5 1.9 4.6 0.6 0.8 1.3 1.5 1.0 0.71 YLR370C 1.1 1.0 1.1 1.4 1.4 4.1 2.1 0.8 1.5 1.9 1.0 1.2 3.1 1.9 1.5 1.6 1.6 2.0 1.41 YLR423C 1.2 1.2 0.7 1.9 1.5 1.2 3.8 2.0 1.2 1.0 1.0 1.7 3.9 1.2 1.3 1.9 1.2 1.6 0.34 YML092C 1.1 3.1 2.4 1.1 0.9 1.9 1.2 1.2 6.4 4.0 2.5 1.2 2.3 1.6 1.4 2.2 1.3 1.5 1.72 YML130C 1.5 2.7 5.3 1.2 0.9 0.6 2.9 2.7 7.8 4.2 1.9 2.3 5.8 1.3 2.4 0.8 1.2 1.2 1.59 YMR214W 0.8 3.8 1.0 1.4 0.8 0.9 1.0 1.1 2.1 1.0 0.7 1.0 2.4 1.1 4.8 0.7 1.1 1.0 0.88 YMR297W 0.7 2.0 3.6 1.9 0.6 1.8 1.2 0.8 1.9 1.0 2.5 1.2 4.2 0.5 2.4 1.9 1.1 1.4 4.10 YNL036W 2.0 1.9 3.2 1.0 1.6 1.1 2.0 2.1 6.6 5.0 1.7 1.4 3.3 5.1 1.6 1.3 1.4 1.9 2.04 YOL005C 1.4 1.4 1.1 0.8 1.6 1.1 1.1 1.0 0.9 1.0 1.6 1.2 2.9 1.2 0.9 1.0 1.2 1.2 1.71 YOR134W 2.0 3.6 1.0 9.5 0.9 1.4 1.1 1.5 1.5 8.2 1.9 2.8 4.4 1.3 1.6 7.7 2.2 4.6 0.28 YOR362C 1.0 1.7 1.0 0.8 1.7 1.4 1.6 1.4 4.3 3.0 1.3 1.3 2.5 1.4 1.0 1.5 1.1 1.8 2.55 YAR009C 0.8 1.3 0.6 1.0 1.4 1.6 2.7 1.4 0.9 1.4 0.9 1.3 2.0 1.0 2.1 0.6 0.8 1.2 7.11 YBL101C 1.0 1.1 1.9 0.9 1.0 0.9 0.8 0.8 3.0 1.4 0.8 1.1 3.5 0.9 2.7 1.4 1.0 1.1 0.39 YBR046C 1.4 1.4 1.7 1.8 1.3 2.6 3.9 1.6 4.6 6.2 2.9 1.2 2.0 1.3 2.1 3.0 1.2 2.0 0.63 YBR139W 1.2 1.4 3.1 1.4 0.8 2.4 1.9 0.7 2.3 1.6 2.3 1.2 2.7 1.1 5.6 2.3 1.2 2.0 1.21 YBR170C 0.8 1.2 0.6 1.4 1.5 1.4 1.9 1.3 6.1 4.2 1.5 1.2 2.7 1.3 1.9 1.3 1.1 1.4 0.72 YBR177C 0.8 1.1 4.0 1.2 1.2 2.3 0.9 0.9 2.1 1.7 0.6 1.2 3.1 1.3 1.4 0.4 0.8 0.9 0.76 YBR212W 0.7 1.2 2.6 1.2 1.0 1.4 0.9 0.6 2.7 2.3 1.1 0.9 2.2 0.7 1.0 1.5 1.1 1.0 0.95 YBR239C 1.0 1.3 0.9 1.5 0.8 1.5 1.0 1.3 0.4 1.2 0.7 1.1 1.9 1.1 1.0 2.7 1.0 0.9 0.31 YCL033C 1.1 2.0 1.7 1.7 1.2 4.6 2.4 1.1 2.3 1.4 1.9 1.6 2.0 1.8 0.8 3.6 2.0 2.0 1.14 YCR062W 0.8 1.9 2.7 2.8 1.4 1.9 0.9 0.7 0.7 1.3 1.2 1.3 2.2 1.0 2.3 1.1 1.1 1.0 0.41 YCR067C 0.9 0.7 1.2 1.3 0.7 0.8 0.8 0.7 1.8 1.6 1.2 0.9 2.0 0.9 2.1 1.4 1.1 0.9 0.62 YDL020C 2.3 1.2 3.4 1.1 1.2 2.5 1.0 2.2 5.6 2.9 1.9 1.1 3.4 1.2 1.5 1.8 1.5 1.7 1.36 YDR168W 1.2 1.4 1.0 0.8 1.5 1.3 2.4 2.1 3.7 2.3 1.5 1.2 2.4 1.4 1.9 1.4 1.2 1.4 1.28 YDR169C 1.0 1.4 1.1 1.3 1.3 1.2 1.1 1.0 1.6 1.4 0.9 0.9 1.9 0.9 1.4 0.9 1.4 1.1 0.40 YDR188W 0.8 1.2 1.0 0.8 0.8 0.8 0.9 1.0 2.9 1.6 0.9 0.9 1.7 0.7 1.3 0.9 0.7 0.8 1.78 YDR264C 0.5 2.6 0.9 1.4 0.9 1.8 3.2 0.8 1.1 3.4 0.9 1.1 2.1 0.7 2.3 1.5 1.2 1.4 1.63 YDR304C 1.0 1.8 2.7 1.3 1.5 2.1 2.0 1.3 3.9 1.9 1.2 1.3 2.3 1.7 1.0 4.0 1.6 1.8 2.23 YDR403W 1.0 1.2 1.6 1.0 1.2 1.1 1.2 1.2 4.1 3.6 1.0 1.0 2.0 1.1 0.9 0.9 0.9 1.0 0.35 YDR427W 0.8 1.1 0.8 0.8 1.5 1.9 1.4 1.2 2.3 2.0 1.2 1.1 2.1 1.0 1.3 1.1 1.0 1.5 2.37 YEL012W 1.3 1.8 1.0 1.8 1.7 1.6 4.7 1.4 4.6 4.2 2.2 1.2 2.2 1.9 1.1 2.5 1.5 2.2 0.74 YER009W 1.3 0.6 2.4 1.2 1.2 2.0 2.8 1.0 0.7 1.0 1.4 1.1 2.0 1.6 0.9 1.5 2.0 2.1 3.35 YER021W 0.8 1.0 0.9 0.9 1.4 1.1 1.5 1.2 3.0 2.2 1.3 1.0 1.8 1.3 0.8 1.4 0.8 1.5 2.02 YER094C 1.0 1.3 0.9 1.1 1.9 1.1 1.8 1.3 2.3 1.7 1.3 1.1 2.1 1.5 0.8 1.5 1.3 1.8 3.01 YER177W 1.4 1.5 2.1 1.5 0.9 1.6 1.2 1.1 1.8 1.7 1.9 1.1 2.2 0.9 1.4 1.0 0.9 2.0 5.81 YFL029C 1.0 1.2 1.2 1.8 1.7 1.0 1.6 1.5 4.3 2.9 2.1 1.1 1.8 1.9 1.3 1.2 1.2 1.4 0.49 YFL038C 1.0 1.2 0.7 1.3 1.5 1.3 1.7 1.4 2.1 1.9 1.7 1.1 2.1 1.5 1.5 2.1 1.2 1.6 2.31 YFR004W 1.0 1.5 0.8 1.4 1.0 1.5 1.3 1.4 3.6 2.6 1.3 1.2 2.0 2.1 1.1 1.3 1.0 1.4 2.44 YFR050C 0.9 1.2 1.1 1.3 1.7 1.5 1.4 1.4 3.1 2.1 1.4 1.5 2.1 1.6 1.5 1.5 1.1 1.7 1.70 YGL011C 1.2 1.5 1.1 1.1 1.8 1.6 1.5 1.3 2.0 2.2 1.5 1.0 2.1 3.0 1.3 1.7 1.3 1.5 1.78 YGL094C 0.8 1.3 0.3 0.9 1.3 1.0 0.8 1.0 1.4 1.1 0.6 0.8 2.3 0.9 1.9 1.0 1.0 0.9 0.51 YGL150C 0.7 0.8 1.2 1.0 0.8 1.1 0.8 0.8 1.4 0.9 0.4 0.8 2.4 1.0 1.3 0.9 0.9 0.8 0.62 YGL207W 0.5 0.6 0.9 0.6 1.3 0.9 0.6 1.0 1.4 1.1 0.7 0.7 2.5 0.8 1.2 0.7 0.9 0.8 0.88 YGR232W 1.2 1.2 1.2 1.7 1.5 1.9 2.0 1.1 3.4 2.2 1.3 1.1 2.4 2.1 0.9 1.8 1.3 1.2 0.96 YGR248W 1.3 1.7 3.2 4.0 0.5 2.3 1.1 1.2 2.8 3.2 2.3 1.1 2.0 1.5 1.5 7.9 1.0 1.5 0.52 YGR253C 1.3 1.4 0.7 1.3 2.0 1.4 1.6 2.0 4.0 3.1 2.4 1.1 3.4 1.8 1.1 1.8 1.5 2.1 2.01 YHR027C 0.5 0.8 1.2 0.6 1.1 0.4 0.9 0.6 3.6 2.2 1.1 1.0 2.1 0.7 1.5 0.9 0.8 1.0 2.06 YHR161C 0.6 1.1 1.3 2.1 1.5 1.2 1.8 0.7 2.5 2.0 1.2 1.0 1.8 1.0 1.4 1.7 1.4 1.5 0.86 YHR169W 0.6 0.5 0.4 0.4 1.1 1.2 0.9 0.9 0.0 0.2 0.4 1.1 3.3 1.1 0.6 1.0 1.6 1.3 0.81 YIL010W 1.0 1.2 1.4 0.8 1.2 4.4 1.5 0.9 1.4 2.2 1.4 1.4 2.3 1.7 1.1 1.7 1.5 1.5 0.70 YIL034C 1.0 0.8 1.5 3.0 0.7 1.7 1.2 0.9 2.1 1.3 1.6 1.0 2.6 1.1 1.0 1.7 1.2 1.5 0.99 YIL142W 0.7 1.1 0.9 1.1 0.8 1.1 0.8 1.1 4.4 3.0 1.7 1.1 1.8 1.0 1.3 0.7 0.9 0.8 1.84 YIR039C 1.4 1.8 4.3 4.2 1.5 3.2 4.1 1.1 4.4 4.1 3.8 1.4 2.9 1.9 2.0 4.2 1.2 1.1 0.45 YJL001W 0.9 1.7 1.2 2.0 1.7 1.6 1.3 3.1 2.8 1.5 1.6 2.9 2.5 1.2 1.8 1.0 1.6 3.00 YJL035C 0.9 1.3 0.8 0.6 1.4 0.7 1.3 1.5 1.7 1.4 0.8 1.1 2.4 1.6 0.7 0.6 1.0 1.0 0.82 YJL053W 1.1 0.9 1.7 1.3 1.1 2.0 1.7 1.3 2.2 2.2 1.6 1.1 1.9 1.3 1.1 1.7 1.3 1.6 0.80 YJL164C 1.1 1.1 1.0 1.9 1.1 2.7 3.1 0.9 2.1 0.8 1.5 1.0 2.1 0.9 0.8 2.1 1.3 1.7 1.04 YJL210W 1.2 1.4 1.6 2.0 0.6 0.6 1.0 1.0 2.0 0.9 2.4 1.0 2.2 0.9 0.8 2.3 0.9 1.0 0.70 YJR117W 1.0 2.1 2.3 0.7 1.2 1.3 1.0 0.8 4.7 2.3 1.0 1.2 2.8 0.8 2.2 0.7 0.8 0.9 1.34 YKL007W 1.2 1.6 1.2 0.9 1.0 0.9 1.5 1.2 2.3 2.4 1.8 1.3 2.5 0.7 1.0 1.0 1.4 1.3 1.13 YKL117W 1.0 1.3 0.8 1.0 1.8 1.0 1.3 1.5 2.9 2.1 1.6 1.0 2.4 1.6 1.6 1.8 1.2 1.8 3.73 YKL193C 1.3 0.8 1.1 1.4 1.1 0.9 2.1 1.4 1.0 1.6 1.7 0.9 2.1 1.2 1.2 2.4 1.2 2.3 0.71 YLR120C 1.2 1.9 2.4 1.6 1.1 1.9 1.5 0.9 1.8 1.6 1.2 1.6 4.8 0.8 2.7 1.7 3.5 2.9 1.53 YLR136C 1.3 9.0 0.6 3.3 1.6 1.7 3.9 1.1 0.9 6.0 1.2 1.3 2.9 0.7 2.1 1.2 1.8 1.4 0.41 YLR178C 1.7 6.9 8.8 4.6 1.0 4.2 3.3 0.9 4.3 4.1 3.7 2.2 7.5 2.8 2.3 10.6 2.0 3.6 1.03 YLR327C 5.5 3.3 14.4 8.2 1.3 5.1 5.7 2.2 3.0 8.3 5.0 1.4 2.8 1.5 0.8 2.8 3.3 5.3 2.23 YLR356W 1.0 2.9 4.9 1.2 1.1 3.4 1.1 0.7 2.3 1.6 3.1 1.5 2.5 2.2 2.8 0.9 1.1 1.0 0.41 YLR362W 1.1 1.2 1.0 3.0 1.5 0.8 1.9 1.4 3.5 3.3 1.5 0.8 2.4 1.2 1.3 1.9 1.2 1.3 0.35 YLR429W 0.7 1.0 0.6 0.9 1.4 0.8 1.3 1.0 0.9 1.3 0.9 1.1 2.3 0.7 1.5 1.0 1.0 0.9 0.86 YMR004W 0.9 0.9 1.3 1.3 1.0 0.5 1.2 1.0 94.2 3.4 2.5 1.0 2.2 2.2 1.3 1.3 0.9 1.3 0.52 YMR219W 0.7 1.1 1.0 0.7 1.6 0.8 1.1 2.3 0.9 1.5 1.5 2.1 0.5 1.7 0.8 1.1 0.9 0.23 YMR275C 0.7 0.7 1.2 0.6 0.7 1.4 0.8 0.8 2.4 2.1 1.1 0.7 2.1 0.8 1.7 1.0 0.9 0.7 0.79 YMR314W 1.2 0.9 1.3 1.3 1.1 1.2 5.9 2.7 1.8 1.0 2.6 1.0 1.2 1.6 1.3 1.6 1.67 YNL006W 1.1 2.1 1.3 1.5 0.9 1.0 1.6 1.1 4.0 4.0 1.1 0.7 2.3 0.8 0.7 0.9 1.0 1.3 1.20 YNL007C 0.7 2.4 5.1 0.8 1.2 0.6 1.2 0.8 3.0 1.7 1.3 0.7 2.1 0.4 0.8 0.5 1.1 1.0 3.62 YNL093W 2.1 6.4 0.4 4.5 1.2 1.6 1.4 0.8 1.7 2.0 1.6 1.1 2.2 1.1 0.6 4.9 3.0 3.1 0.32 YNL333W 1.0 1.4 1.7 2.3 1.5 1.5 2.9 2.1 2.3 2.1 2.0 1.0 2.2 1.9 1.0 1.4 1.4 1.1 0.49 YNR010W 1.3 1.2 0.5 2.8 1.8 1.3 1.5 1.1 1.7 0.9 1.4 0.8 2.8 1.3 0.8 1.2 1.7 2.3 0.37 YNR069C 1.5 1.3 0.7 0.4 1.4 1.7 1.4 1.4 5.5 5.8 2.5 1.2 3.4 2.1 1.0 0.8 1.1 0.9 0.18 YOL164W 0.9 4.4 1.0 1.5 1.6 1.2 2.2 1.0 4.9 3.6 1.0 1.1 3.4 1.3 1.0 1.1 1.1 1.3 0.45 YOR036W 1.8 0.9 1.4 1.6 1.1 1.7 1.8 1.4 1.2 1.9 1.3 1.2 2.1 1.2 1.2 1.3 1.6 1.7 0.98 YOR117W 0.8 1.3 1.7 0.8 1.2 1.1 3.3 1.0 3.5 1.8 1.2 2.5 2.3 1.0 1.4 1.2 1.4 0.9 1.42 YOR124C 0.6 1.1 1.3 0.8 1.1 0.9 1.1 1.3 2.0 1.9 1.2 0.9 2.1 0.8 1.3 0.9 1.0 1.0 0.65 YOR132W 0.9 1.6 0.8 2.8 1.1 1.6 1.4 1.2 2.8 1.6 1.3 0.7 2.5 0.7 1.5 1.6 1.2 1.6 0.46 YOR157C 1.0 1.3 1.2 1.3 0.7 1.2 1.2 1.2 5.7 2.6 1.6 1.3 2.4 2.2 1.9 0.9 1.2 1.2 1.23 YOR185C 1.1 1.3 1.9 1.1 1.2 3.0 1.3 1.4 1.9 2.9 1.2 1.5 2.2 2.1 1.0 2.2 0.9 1.1 1.67 YOR259C 0.8 1.1 0.8 0.9 2.0 0.8 1.3 1.1 2.7 1.5 1.0 0.8 1.8 1.2 1.3 1.4 0.9 1.5 2.33 YOR261C 1.0 1.4 0.6 0.9 1.5 1.4 1.9 2.6 5.5 2.5 2.1 0.9 2.5 1.8 1.3 2.0 1.0 1.9 2.80 YOR288C 0.9 1.3 1.1 1.1 1.1 1.0 2.0 1.9 0.9 1.0 1.4 1.4 2.4 0.8 1.8 1.4 1.5 1.6 0.79 YPL109C 1.1 2.5 0.5 1.2 1.2 1.2 1.8 1.1 1.2 1.5 −0.2 0.9 1.8 1.3 1.3 1.9 1.2 1.2 0.21 YPL149W 1.5 1.5 0.6 2.8 0.8 0.9 1.2 1.1 5.6 3.7 1.2 0.9 2.3 1.0 0.8 1.2 2.2 2.9 1.39 YPL154C 0.7 3.3 4.2 1.2 1.2 3.5 1.5 0.8 2.8 1.7 1.8 1.5 3.1 0.8 4.0 1.8 1.6 2.0 3.78 YPR103W 0.7 1.1 1.3 0.7 1.7 1.2 1.6 1.0 5.5 2.0 0.9 1.2 2.8 1.8 1.0 1.1 1.2 1.5 1.93 YPR108W 0.8 1.0 1.3 0.6 1.3 1.5 1.6 1.6 3.7 2.8 1.8 1.0 2.6 1.0 1.3 1.2 1.0 1.3 2.25 YCL027W 0.7 2.0 1.0 1.0 1.2 1.3 1.0 0.6 0.7 16.3 0.9 0.8 1.1 1.2 3.6 1.1 0.7 0.8 0.30 YDR055W 1.7 2.1 2.2 2.8 1.7 3.9 1.5 1.6 0.8 2.4 2.2 1.4 3.1 0.9 5.7 3.4 2.0 1.9 1.55 YEL042W 0.6 0.9 1.7 0.9 0.7 0.5 0.5 0.7 0.2 0.3 1.6 1.0 0.4 0.6 4.8 0.6 0.7 0.8 1.21 YGR136W 0.9 1.2 1.3 0.7 1.2 1.1 1.5 1.3 2.1 2.2 1.3 1.2 1.7 1.1 2.6 2.2 1.3 1.8 1.42 YHR142W 1.5 0.8 2.1 0.8 1.3 1.2 0.9 1.3 0.4 0.9 1.1 1.3 1.2 1.2 4.8 1.0 1.3 1.3 1.17 YJL073W 0.8 0.8 2.5 0.7 1.2 2.0 1.0 1.7 0.7 0.5 1.0 1.6 1.1 2.6 0.8 1.1 1.0 0.43 YJR004C 0.2 0.8 3.4 0.6 1.1 1.2 0.4 0.4 0.3 0.7 0.7 0.8 0.3 0.7 3.2 0.3 0.4 0.4 2.12 YKL039W 0.8 1.1 2.4 0.8 0.7 4.9 2.0 0.8 1.3 3.3 1.0 0.9 1.9 0.8 3.1 1.5 1.2 1.3 1.13 YLR250W 1.5 1.0 1.0 1.4 1.4 1.1 1.9 1.3 2.7 2.4 1.4 1.0 1.2 2.5 2.6 2.1 1.4 2.2 2.90 YOR181W 1.0 0.9 1.1 1.4 0.7 0.9 0.7 0.7 0.6 0.5 1.0 0.8 1.2 0.9 3.4 1.0 1.1 0.6 0.39 YOR198C 1.0 0.7 1.4 1.0 0.8 0.9 1.6 1.3 2.4 1.4 1.4 1.5 1.8 1.1 3.8 0.8 1.1 1.5 1.76 YPL089C 1.2 1.0 0.5 1.8 1.4 0.8 0.9 0.8 0.4 2.5 0.9 0.7 1.3 0.8 2.6 0.9 1.5 1.1 0.37 YBR214W 0.9 2.1 5.7 2.0 1.1 0.8 1.1 0.7 2.2 3.5 3.2 1.2 2.1 0.9 5.1 1.3 1.1 1.2 0.51 YDR085C 1.9 1.8 1.6 3.4 0.9 2.1 4.1 2.0 0.4 2.3 1.7 1.6 1.1 1.6 3.1 2.3 1.3 1.8 0.37 YDR259C 1.4 1.0 0.4 1.4 1.0 0.5 2.8 1.4 1.0 1.8 1.2 1.0 2.0 1.5 2.9 0.9 1.0 0.8 0.28 YDR388W 0.7 0.7 1.2 1.0 0.7 1.0 1.1 0.8 1.4 0.9 1.6 0.8 1.7 0.6 2.6 1.0 1.2 1.3 0.99 YDR432W 0.5 0.8 1.0 1.4 1.6 0.6 0.5 0.5 0.7 0.8 0.6 0.7 1.4 0.5 2.6 0.6 0.7 0.7 2.38 YDR481C 0.7 2.3 1.3 0.7 1.0 0.9 0.7 1.0 1.9 1.6 1.2 0.9 1.5 0.9 3.5 1.3 1.2 1.4 1.43 YDR510W 1.0 1.3 1.5 1.3 0.7 1.0 1.6 1.5 2.7 2.5 1.6 1.4 2.0 1.9 2.2 1.5 1.1 1.5 1.57 YGR189C 1.1 0.9 1.5 3.5 0.7 0.5 0.6 1.0 0.3 0.9 1.5 1.3 1.2 0.9 9.3 0.6 2.3 1.7 1.51 YIL123W 1.0 0.5 1.2 1.5 0.6 0.5 0.5 0.6 0.1 0.2 1.2 0.8 0.4 0.3 4.8 0.7 1.3 1.0 1.67 YIL140W 0.7 1.0 1.5 1.4 0.8 0.5 0.5 0.7 0.7 0.6 0.9 1.0 0.5 0.9 3.3 0.6 0.7 1.0 0.62 YKL096W 1.4 0.6 8.1 1.6 0.6 0.6 0.2 0.5 0.0 0.5 3.5 0.3 0.1 0.5 2.3 0.4 0.5 0.7 2.04 YLR391W 0.7 2.9 0.8 1.2 1.5 0.7 0.7 0.4 0.7 1.4 1.0 0.9 0.5 3.9 1.3 1.4 0.9 1.72 YMR094W 1.0 0.5 1.3 1.7 0.9 0.5 0.8 1.0 −0.1 0.9 1.0 0.9 1.4 2.8 6.6 1.0 1.0 1.0 0.23 YMR104C 1.9 14.3 2.2 2.6 0.7 1.9 1.5 0.9 0.6 3.2 1.1 1.0 1.5 1.1 2.5 2.3 2.8 1.9 0.51 YMR276W 0.6 1.4 1.5 0.7 1.3 0.8 1.1 0.8 1.8 1.7 1.9 1.2 1.9 1.2 3.3 0.9 1.2 0.7 0.47 YOL013C 0.9 1.0 1.0 1.5 0.7 1.1 1.7 1.0 0.8 1.0 1.4 1.1 1.8 0.9 2.7 1.3 1.1 1.4 0.65 YOR355W 0.7 0.6 1.1 0.8 1.0 1.6 1.1 0.8 0.1 0.8 1.2 0.9 1.1 0.6 3.2 0.8 0.8 0.9 0.98 YCR071C 1.1 0.7 0.9 0.8 1.2 2.5 1.4 0.9 0.6 1.2 1.1 1.1 1.3 1.7 1.1 1.5 1.2 1.3 0.96 YDL008W 1.1 1.0 1.0 1.1 1.8 2.7 2.0 1.2 2.3 3.0 0.9 1.2 2.0 2.2 0.7 1.3 1.5 1.6 0.95 YDR115W 1.3 0.9 0.6 1.5 1.4 2.3 1.6 1.3 1.1 1.0 1.2 0.9 1.1 1.5 0.8 2.2 1.2 1.4 1.50 YER130C 0.9 1.6 0.5 0.8 1.7 2.7 1.5 1.2 0.5 1.3 0.9 1.0 1.6 0.8 1.1 0.7 3.0 2.5 1.36 YMR226C 1.1 1.8 1.4 1.6 0.9 2.6 1.8 1.6 2.6 2.2 1.4 1.1 1.6 1.6 2.0 1.7 1.6 2.0 2.03 YOR383C 0.9 4.3 2.6 0.9 0.9 6.8 8.0 1.0 1.2 4.5 1.4 1.1 1.2 0.6 1.1 3.0 1.4 1.1 0.68 YAR010C 0.8 1.2 1.2 0.8 1.0 2.3 1.9 1.3 1.2 1.1 0.9 1.0 1.4 1.0 1.8 0.7 1.5 1.0 4.69 YBL043W 1.2 1.2 1.1 1.3 1.1 26.9 1.5 2.1 0.5 14.7 1.5 0.9 1.8 1.9 1.8 2.3 2.3 1.8 0.47 YCR004C 1.7 1.0 12.0 1.2 1.8 1.4 1.2 4.7 2.1 1.9 0.8 1.3 3.7 0.8 4.9 1.4 3.5 3.02 YCR088W 0.9 1.1 1.2 0.9 1.1 2.0 1.2 0.5 0.8 0.9 1.0 1.3 1.9 0.9 2.8 0.7 1.4 0.9 0.47 YDL238C 0.7 1.0 1.1 1.7 0.9 2.1 1.4 5.8 1.7 2.7 1.1 0.9 2.0 1.2 1.3 1.7 1.1 1.3 0.35 YDR084C 0.9 0.9 1.5 1.1 1.2 2.1 0.9 0.7 0.6 0.6 0.7 0.7 1.0 1.0 3.9 1.0 2.0 1.3 1.12 YDR104C 0.8 1.1 1.2 1.2 1.3 1.7 1.0 1.3 2.8 2.7 1.0 1.1 1.6 1.4 1.4 0.9 0.9 1.0 0.34 YDR315C 1.0 1.4 1.0 1.3 0.9 9.4 1.4 1.4 1.1 1.6 1.1 0.6 1.6 1.4 1.5 1.5 1.2 1.2 0.48 YDR358W 0.7 1.1 0.7 1.1 1.4 2.5 2.8 1.2 2.9 3.2 1.0 1.1 3.2 1.2 0.9 2.2 1.9 1.9 0.50 YEL066W 2.0 2.9 1.5 2.2 0.8 2.2 1.8 1.4 1.3 2.4 1.9 0.8 1.6 1.9 1.0 1.9 1.0 1.1 0.64 YER039C 1.0 1.2 1.0 4.1 1.5 1.6 1.3 0.7 1.2 0.8 1.2 0.9 2.1 1.2 1.2 1.8 1.7 1.1 0.42 YER107C 0.9 0.5 1.0 0.6 1.3 2.5 1.0 0.8 0.4 0.5 0.7 0.7 0.9 1.1 0.7 0.9 1.1 1.2 0.92 YFL028C 1.2 1.1 0.7 1.5 1.7 1.7 2.0 1.5 2.7 1.8 1.3 1.1 1.4 1.6 0.8 1.9 1.2 1.5 1.28 YFL043C 1.0 1.2 0.6 1.2 1.2 1.8 1.8 1.0 2.2 3.8 1.1 0.9 1.5 1.5 1.1 2.0 1.5 1.2 0.38 YGL229C 0.6 0.7 0.9 0.8 1.0 2.2 2.2 0.7 1.8 1.7 1.1 1.1 1.7 1.0 0.2 1.8 1.1 0.9 0.44 YGR257C 0.7 0.8 0.9 1.1 1.3 2.1 2.4 1.0 1.5 1.9 1.2 0.9 2.0 0.9 1.3 1.3 1.1 1.3 0.84 YHR004C 0.9 1.1 0.8 1.1 1.5 2.0 1.5 0.9 1.1 0.6 0.8 0.9 1.1 0.8 1.2 2.4 1.4 1.6 0.84 YHR071W 1.5 1.1 0.6 1.6 1.5 2.0 1.0 1.7 1.0 7.2 1.8 0.8 2.3 1.6 3.0 1.7 2.6 1.0 0.79 YJL089W 1.1 1.5 1.0 0.8 1.1 1.6 1.1 1.1 1.6 3.9 0.6 1.2 1.8 1.8 6.4 1.2 1.2 1.1 0.21 YJL116C 0.9 1.8 1.3 1.9 1.3 3.4 0.8 1.8 2.4 2.6 2.9 1.1 4.3 2.6 1.0 1.3 1.2 0.7 1.01 YJR086W 1.2 1.1 0.8 1.4 1.3 1.9 1.7 1.1 1.4 1.1 1.0 0.8 0.9 2.2 2.0 1.4 1.4 1.6 1.24 YKL008C 1.2 0.6 2.0 0.8 0.9 3.8 1.4 1.2 0.3 0.4 1.5 1.5 1.7 0.8 1.3 2.1 1.4 1.9 2.11 YKL013C 1.4 0.9 1.4 1.1 1.9 1.9 1.8 0.9 1.5 1.4 1.1 0.7 1.3 1.4 1.2 1.5 1.6 1.7 1.55 YKL041W 1.2 0.8 1.1 1.0 1.3 2.2 1.0 1.6 1.6 1.5 1.2 0.8 1.3 1.3 1.0 2.5 1.1 1.3 0.91 YKL139W 0.9 0.7 1.4 0.8 2.8 3.5 2.6 1.2 1.6 1.5 1.4 0.8 1.6 1.0 1.0 1.3 1.9 0.8 0.62 YKR014C 1.1 1.3 0.7 1.1 1.5 2.1 1.7 1.6 2.4 2.0 1.1 1.1 1.5 1.8 1.4 2.4 1.0 1.7 2.05 YLR093C 1.3 0.8 0.7 1.2 1.4 2.9 1.9 1.2 1.5 1.3 1.0 1.0 1.3 1.3 0.9 2.4 1.7 3.2 1.90 YLR118C 1.0 1.1 1.6 1.0 1.0 2.5 1.5 1.0 1.1 1.3 1.2 1.0 1.4 1.5 0.8 3.5 1.3 1.9 1.17 YLR251W 1.8 0.8 4.2 4.6 1.6 2.1 2.6 1.2 2.1 1.3 4.1 0.8 1.7 1.3 0.8 2.5 2.1 3.8 0.78 YMR027W 0.8 2.6 0.7 0.8 1.1 2.1 2.0 0.9 1.1 1.4 1.1 0.9 2.4 0.9 4.0 0.8 1.3 1.2 4.05 YMR262W 1.0 1.3 1.9 1.1 1.2 2.0 1.9 1.0 3.0 1.2 1.3 0.8 1.7 0.9 0.3 1.0 1.0 1.2 0.65 YNL214W 1.2 0.9 1.1 1.1 1.4 2.3 1.3 1.1 1.5 1.5 0.6 0.8 1.2 1.7 0.9 2.0 1.1 1.2 0.47 YOR149C 0.7 0.9 1.0 0.8 1.1 2.3 1.0 0.7 0.4 1.0 1.0 0.9 1.3 0.9 1.3 1.1 1.0 1.2 0.76 YOR165W 0.9 1.5 0.7 0.8 0.8 2.2 0.9 1.1 0.8 1.3 1.3 0.7 0.9 0.8 0.8 1.0 0.9 1.0 1.03 YOR285W 1.4 6.0 3.5 1.9 1.7 2.1 4.0 1.2 4.0 2.9 2.3 0.9 2.1 1.6 2.0 2.9 2.3 3.3 2.62 YOR367W 1.0 0.9 1.7 0.9 1.1 3.3 1.9 1.1 1.1 1.1 1.4 0.5 0.8 1.5 1.1 1.3 1.4 1.4 0.60 YPL018W 1.0 1.4 1.0 0.5 1.8 2.1 0.9 1.1 1.4 1.2 1.3 1.1 2.2 1.3 0.9 0.8 1.3 0.8 0.22 YPL203W 1.3 1.0 2.2 1.0 2.1 1.8 2.1 1.1 1.8 2.1 1.5 0.9 1.5 1.0 0.6 2.3 1.3 1.7 0.79 YPL255W 0.8 0.3 1.1 0.6 0.9 2.0 0.6 0.9 0.1 0.1 0.7 0.6 0.6 0.7 0.6 0.7 0.8 0.7 0.55 YPR073C 1.2 1.9 0.5 1.4 1.8 2.0 2.5 1.5 1.3 2.6 0.9 0.8 1.4 1.5 0.8 1.8 1.4 1.8 1.55 YDR518W 0.8 1.7 1.1 1.2 1.6 1.2 2.7 1.1 0.2 1.2 1.0 1.5 1.8 0.8 2.5 1.7 1.4 1.6 0.93 YOR381W 0.8 2.0 0.8 1.8 1.0 1.0 3.6 0.8 1.2 3.5 2.6 1.1 1.7 0.8 0.6 2.5 0.8 0.9 0.38 YBR109C 1.6 1.3 2.4 1.1 1.0 1.4 2.4 1.7 3.8 3.3 1.5 1.4 2.0 2.0 1.4 1.9 1.4 1.9 2.15 YBR201W 1.2 4.3 1.2 2.4 1.2 1.0 3.4 2.2 0.8 1.0 1.1 1.7 1.9 1.1 1.6 1.5 1.8 1.6 0.75 YDR041W 1.2 1.1 0.6 1.8 2.0 1.6 2.4 1.2 1.3 1.3 1.2 0.8 0.9 1.4 1.0 2.4 1.5 2.5 1.85 YER136W 0.9 1.1 1.1 1.4 1.6 1.3 2.1 1.3 1.4 1.6 1.7 0.9 1.3 0.8 1.2 1.6 1.3 1.7 2.31 YER159C 1.1 0.9 0.2 1.6 2.1 1.3 2.0 1.4 0.2 0.9 1.6 0.9 0.9 1.1 2.2 1.1 1.6 1.9 0.99 YJL030W 1.6 1.4 0.5 1.0 1.3 1.1 1.9 1.6 2.3 1.9 1.4 1.0 1.4 2.1 1.5 1.9 1.3 1.5 0.87 YJR029W 0.8 1.3 0.6 0.8 1.0 2.4 0.9 1.1 1.5 0.6 1.0 2.1 1.1 1.8 0.7 0.8 1.1 5.84 YJR099W 1.4 0.9 1.1 1.3 1.5 2.1 2.0 1.4 1.4 2.4 1.3 0.7 1.5 2.1 0.5 2.0 1.1 1.7 0.94 YJR122W 2.0 1.4 2.5 1.1 1.3 1.4 1.8 1.4 5.3 6.1 2.4 0.9 1.3 1.4 0.8 1.9 1.0 1.1 0.43 YJR125C 1.0 1.0 1.2 1.0 1.2 1.3 1.9 0.9 1.8 1.3 1.1 0.9 1.5 1.1 1.3 2.0 1.2 1.4 0.90 YKL190W 1.1 1.3 0.4 0.9 1.5 2.0 1.1 1.8 1.9 1.5 0.9 1.3 1.7 1.4 1.8 1.3 1.3 1.14 YLL051C 0.8 1.1 1.0 1.5 1.4 1.2 2.0 0.9 0.9 1.8 0.7 1.1 1.3 0.8 1.2 0.8 1.0 1.0 0.81 YLR090W 0.7 1.1 0.8 1.3 1.2 1.3 2.2 0.9 1.8 1.4 1.0 0.8 1.7 1.0 0.8 1.9 0.8 1.0 0.67 YMR051C 0.9 2.8 0.8 1.3 1.7 1.2 2.6 0.9 1.0 1.4 1.1 0.9 1.3 1.2 1.7 1.0 1.8 1.2 3.91 YMR139W 1.0 3.4 2.5 1.5 1.2 1.5 2.2 0.9 2.8 2.4 1.3 0.9 1.6 1.3 0.9 2.3 1.1 2.0 0.89 YNL015W 2.3 6.7 1.8 2.4 1.8 1.7 3.5 2.2 2.1 4.3 2.1 2.8 3.9 1.6 1.4 5.3 3.0 5.2 1.03 YNL079C 1.1 1.0 0.4 1.0 1.7 1.1 1.9 1.6 1.5 1.2 1.3 1.2 1.8 1.0 1.5 1.4 1.0 1.9 3.26 YNL223W 1.1 1.2 0.6 1.7 1.0 1.8 2.2 1.4 3.3 1.9 1.3 1.3 2.0 1.2 1.0 2.1 1.0 1.5 0.34 YNR007C 1.2 1.8 0.7 1.0 1.5 1.3 1.9 1.2 2.5 2.0 0.7 0.9 1.5 1.5 0.6 2.0 1.4 1.6 0.49 YNR035C 0.8 1.2 1.7 1.0 0.8 1.1 2.6 1.1 2.9 1.5 1.5 1.1 1.7 1.0 1.3 1.6 1.4 1.8 1.60 YOL016C 1.3 2.0 0.4 2.0 1.6 0.9 3.0 1.3 1.9 1.6 1.3 1.4 3.0 0.7 0.5 1.6 4.3 3.8 2.10 YOL104C 1.0 1.7 0.2 1.8 1.9 1.4 2.6 1.4 0.2 1.7 1.2 0.8 0.6 2.2 1.3 0.5 1.1 0.9 0.32 YPR107C 1.4 1.0 1.2 1.9 1.5 1.3 2.0 1.3 2.4 2.4 1.2 0.7 1.4 1.7 1.0 1.4 1.2 1.5 0.81 YOL152W 0.2 0.6 1.0 0.8 0.7 1.8 2.4 4.1 0.9 1.2 5.9 0.8 0.5 0.4 0.8 1.2 1.1 1.2 0.91 YAL007C 1.3 0.9 0.9 1.5 0.6 0.7 1.5 1.7 1.1 0.9 2.0 1.3 2.0 1.3 2.5 0.8 1.2 1.5 1.74 YDL043C 1.0 0.8 0.8 1.2 1.1 0.5 0.9 1.3 0.8 0.8 3.9 0.9 0.8 1.2 0.8 1.2 0.8 0.8 0.78 YDL212W 1.0 1.2 1.6 1.2 1.1 0.4 0.7 0.9 0.4 0.6 2.0 0.8 0.5 1.0 1.1 0.9 1.1 1.7 4.27 YDR183W 1.2 0.7 0.9 1.4 1.5 1.4 1.8 1.8 2.5 2.9 1.8 1.1 1.4 1.9 1.4 1.3 0.8 1.0 0.61 YGL089C 0.4 0.7 2.0 1.0 1.5 0.5 0.4 1.0 0.0 1.9 2.3 0.4 0.2 1.4 0.9 0.2 0.3 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1.1 1.2 0.64 YKR102W 0.8 1.6 1.4 0.8 0.9 0.7 2.4 1.4 3.3 0.8 2.7 1.8 1.1 1.5 1.5 0.9 0.19 YLL054C 1.2 0.6 0.5 1.2 1.4 1.9 1.1 1.1 2.4 1.4 0.5 0.7 1.7 1.2 0.9 0.9 1.0 1.0 0.33 YLR200W 1.4 0.9 0.5 1.2 1.7 1.2 1.9 1.4 2.2 2.6 1.1 0.9 1.3 2.3 0.9 1.2 1.1 1.5 1.12 YLR248W 0.9 0.7 1.1 1.4 1.9 1.2 1.2 1.1 2.3 1.1 1.0 0.7 1.2 0.9 1.2 1.7 1.1 1.7 1.58 YLR266C 0.9 1.3 0.7 1.5 0.7 1.0 1.6 1.1 2.2 2.6 1.1 1.0 1.3 1.0 0.8 1.7 0.8 1.4 0.74 YML088W 0.9 1.6 0.3 0.5 1.5 0.7 1.1 1.1 4.0 2.2 0.5 1.0 1.3 1.1 1.4 0.8 0.8 0.8 0.58 YMR091C 1.0 0.7 0.8 1.0 0.7 0.8 0.8 1.3 2.1 1.3 0.9 0.8 0.9 1.5 0.9 1.3 0.9 1.2 1.03 YMR110C 1.0 1.4 1.8 1.9 1.3 2.1 1.9 0.9 2.3 1.6 1.6 0.9 1.8 0.8 0.9 2.7 1.5 2.5 1.63 YMR255W 1.2 1.4 0.7 1.8 1.3 0.9 1.5 1.4 2.8 2.4 1.2 0.9 1.1 1.6 1.0 1.3 1.5 2.0 0.97 YNL039W 0.7 0.8 0.3 0.4 2.1 0.8 1.1 1.2 2.1 1.8 0.4 0.9 0.8 0.8 1.3 1.3 0.9 1.1 0.61 YNL077W 1.5 1.1 2.3 1.2 1.5 0.9 1.2 1.0 4.4 5.1 1.0 0.7 1.5 0.5 0.3 0.6 1.3 1.0 0.78 YNL083W 0.8 1.4 1.3 1.2 0.8 0.7 0.9 1.1 3.1 1.6 0.9 0.9 1.2 0.9 0.8 1.8 0.8 1.1 0.37 YNL147W 1.3 2.4 0.6 0.7 2.0 1.5 1.4 1.8 2.1 2.9 1.2 0.8 1.0 2.0 1.2 1.7 1.0 1.6 1.32 YNR006W 1.1 1.8 0.5 0.9 1.5 0.9 1.5 0.9 2.2 2.3 0.8 0.9 1.6 0.9 1.2 1.1 1.8 1.2 0.40 YNR034W 0.9 1.4 5.3 1.6 1.0 0.9 1.3 1.0 3.0 2.1 1.3 0.9 1.4 0.9 1.1 2.3 0.7 1.1 0.64 YNR047W 0.7 1.0 1.7 0.5 1.1 1.0 1.0 0.8 2.0 1.2 0.6 0.9 1.5 0.9 1.2 1.5 0.9 1.0 0.44 YOR023C 0.7 1.2 1.3 0.8 1.2 1.8 1.1 0.6 3.5 1.3 0.9 1.1 1.9 0.9 1.6 0.8 1.1 0.8 0.37 YOR058C 2.0 1.4 2.0 0.6 0.9 0.9 0.8 1.7 6.4 4.5 1.4 0.7 1.7 1.7 1.1 1.6 0.9 1.0 0.31 YOR069W 0.8 1.6 0.7 1.3 1.0 0.5 1.2 1.1 1.9 1.4 2.8 0.9 1.1 1.3 1.4 1.5 0.8 1.1 0.69 YOR229W 0.9 0.9 1.0 0.8 1.5 1.3 1.1 0.8 2.5 0.8 0.7 0.8 1.3 1.0 1.2 0.9 0.9 1.0 0.58 YOR256C 1.0 0.8 0.9 1.5 1.7 0.9 1.4 1.1 2.7 1.8 1.7 0.7 1.6 1.1 1.1 1.5 1.2 1.5 0.53 YPL020C 1.1 0.7 0.7 1.3 0.8 0.8 1.1 1.1 2.3 1.6 1.1 0.9 1.1 1.1 1.6 1.2 1.3 1.4 0.91 YPL105C 0.6 0.8 0.6 0.7 1.1 1.2 0.7 1.0 3.4 1.4 0.6 0.7 1.0 0.6 1.1 0.5 0.8 0.6 0.80 YPR066W 1.2 2.2 1.1 2.2 1.3 0.7 1.3 0.8 2.3 1.9 0.9 0.8 1.4 1.2 0.7 1.6 1.1 1.2 0.41 YPR081C 0.9 1.0 1.0 1.1 0.8 1.1 1.1 1.0 4.2 2.6 0.9 1.0 1.4 1.1 1.3 1.8 0.9 1.3 0.34 YPR140W 0.9 1.2 0.8 1.8 0.9 3.0 1.9 1.1 2.1 1.3 0.8 0.8 1.3 1.4 1.7 2.4 0.8 1.3 0.47 YPR155C 0.9 2.5 1.5 1.4 0.9 0.9 1.4 1.0 2.0 1.3 0.9 0.9 1.3 1.2 0.5 3.4 0.8 1.6 0.40 YPR185W 0.7 0.9 0.3 0.4 1.1 0.9 1.2 1.0 2.5 1.7 0.9 0.8 1.7 1.0 1.1 1.3 1.3 1.1 0.68 YBR076W 2.3 1.1 1.4 5.0 0.9 0.8 1.0 0.7 0.4 1.8 0.8 0.9 1.9 1.2 1.1 0.5 1.4 1.2 0.36 YDR373W 1.7 0.8 0.5 1.3 1.8 0.9 1.4 1.9 2.5 2.8 1.7 0.5 1.0 2.1 1.6 1.4 1.2 1.6 1.08 YFR014C 2.1 2.4 0.8 2.6 0.7 0.8 1.4 1.3 1.0 1.6 1.8 0.9 1.3 1.0 0.6 2.3 1.2 2.9 0.94 YHR136C 2.4 13.6 1.4 2.1 2.4 1.4 0.5 1.3 0.1 2.0 2.0 1.2 0.3 1.7 0.5 1.3 1.6 2.5 1.33 YIL129C 0.8 5.8 1.0 1.2 0.3 2.1 1.8 1.5 1.9 0.9 1.0 1.0 1.3 0.8 0.25 YMR077C 1.1 3.9 1.1 1.8 1.0 0.5 1.4 1.7 1.9 2.5 1.5 0.9 0.8 1.6 1.7 2.3 0.9 1.3 0.59 YBR264C 1.2 3.7 1.5 1.5 0.7 0.9 1.3 1.2 0.9 1.1 1.0 1.0 0.9 1.6 1.1 1.8 0.9 1.3 0.61 YPL177C 1.2 3.7 0.9 1.3 0.7 0.8 0.8 1.3 0.5 1.0 1.4 0.8 0.8 1.3 0.6 1.9 1.2 1.1 0.75 YGL056C 0.7 3.5 1.3 1.0 0.6 0.4 1.0 0.9 0.4 0.6 0.0 1.1 0.8 1.1 1.2 1.5 0.9 1.1 0.47 YBL101W-A 1.0 5.7 0.7 0.6 1.0 1.4 1.3 1.5 1.2 2.1 1.2 1.1 2.0 1.5 2.1 1.1 1.3 1.2 1.24 YER072W 1.6 2.3 1.6 1.3 1.2 1.5 0.7 1.2 0.5 1.1 1.7 1.1 0.6 1.5 0.9 1.1 1.7 1.7 1.69 YMR112C 1.2 4.2 0.9 1.2 1.0 0.7 1.5 1.6 1.4 1.3 0.9 1.0 0.9 1.8 0.9 1.4 1.1 1.6 0.57 YJR058C 1.3 2.0 1.3 1.5 1.1 1.6 1.3 1.2 1.9 2.6 1.2 0.7 0.8 1.8 0.8 1.2 1.3 1.2 1.00 YML055W 1.7 2.3 0.6 2.0 0.9 1.2 1.7 1.7 1.0 1.4 1.4 1.0 1.7 1.9 0.6 1.4 1.2 1.5 1.08 YDR080W 0.9 1.8 0.5 0.6 1.2 1.5 1.6 1.2 1.7 2.6 1.2 1.0 2.0 1.1 1.2 1.7 1.2 1.3 0.68 YNR030W 0.6 2.1 2.2 0.7 0.8 1.2 1.0 0.6 1.0 1.4 1.2 0.8 1.5 0.6 1.1 0.4 0.9 0.8 1.19 YNL196C 1.1 1.8 1.4 1.3 0.9 1.2 1.0 0.7 0.5 2.2 0.7 1.0 2.2 1.2 0.8 2.1 1.1 1.2 0.50 YOR148C 1.4 1.4 0.5 1.8 0.9 0.9 1.2 1.5 0.8 0.8 1.3 0.9 1.4 1.4 1.0 1.3 1.0 1.3 1.08 YER029C 1.0 1.6 0.4 1.9 1.7 1.2 1.1 1.5 1.4 1.1 0.8 0.9 0.9 1.4 1.1 1.7 0.9 1.3 1.20 YLR360W 0.9 2.0 0.5 0.7 1.9 1.4 1.7 1.3 0.9 1.3 0.9 0.9 0.7 1.1 0.8 2.1 1.2 1.4 0.53 YGR239C 1.3 1.3 0.7 1.3 1.2 2.3 1.2 1.5 0.5 3.8 1.4 1.0 1.0 1.4 1.3 1.1 1.1 1.3 0.49 YDL229W 0.9 1.9 0.4 0.6 1.2 1.0 1.3 1.2 1.4 0.9 1.6 0.9 1.0 1.3 1.2 1.0 1.2 1.1 0.76 YJR027W 0.8 1.9 0.8 0.7 1.5 2.0 1.0 1.2 1.3 1.1 0.8 1.3 1.1 2.3 0.7 0.7 1.1 4.88 YKL198C 1.2 1.4 0.8 0.2 0.9 1.0 1.2 0.6 0.0 0.8 1.4 0.7 1.9 6.6 2.6 0.7 1.0 0.8 0.17 YBR031W 1.1 0.8 4.1 1.4 1.4 0.7 0.5 1.0 0.1 1.0 0.9 1.0 0.3 0.4 0.9 0.7 1.0 0.8 7.58 YBR118W 1.3 0.8 2.9 1.2 1.0 1.3 1.0 1.3 0.5 0.9 1.0 0.8 0.8 0.7 1.6 0.6 1.2 0.9 8.91 YCR106W 0.9 1.1 2.8 1.1 0.8 1.4 0.9 0.8 2.0 1.2 1.2 0.8 1.2 0.8 1.3 1.2 1.1 1.2 0.76 YDR012W 0.9 0.8 3.9 1.2 1.1 0.9 0.5 1.1 0.3 0.7 0.9 1.2 0.2 0.4 0.8 0.7 1.0 0.7 7.07 YDR134C 1.0 0.7 3.9 1.9 0.8 1.1 0.4 0.6 0.1 0.5 1.9 0.6 0.4 0.5 0.8 0.9 0.7 1.1 5.84 YDR276C 1.5 1.6 6.1 1.4 0.7 1.1 1.0 1.1 1.1 2.7 1.4 0.9 1.1 1.3 2.2 3.6 1.3 2.4 2.48 YGR279C 0.9 0.7 3.6 1.0 1.2 1.6 0.8 0.6 0.3 0.7 0.9 0.7 0.3 0.4 1.3 0.8 1.0 0.8 3.77 YJL059W 1.0 1.7 3.1 0.8 0.9 1.6 1.1 0.8 1.7 1.6 1.8 1.0 1.6 1.3 0.9 0.8 1.1 1.0 0.39 YKL056C 1.3 0.7 2.6 1.4 1.7 0.9 0.5 1.0 0.1 0.7 1.1 0.8 0.1 0.7 0.9 0.6 0.8 1.2 6.68 YKL097W-A 1.5 1.3 4.2 1.3 1.2 0.9 0.2 0.7 0.0 0.4 1.6 0.7 0.2 0.6 2.0 0.8 1.1 1.4 4.01 YNL209W 0.9 0.9 2.7 0.9 1.3 0.9 0.5 1.1 0.2 0.8 0.9 0.9 0.5 0.6 0.9 0.3 0.6 0.6 8.06 YNL307C 0.8 0.6 3.1 1.3 1.0 1.9 0.9 0.9 1.0 0.9 1.0 1.0 1.0 0.7 0.6 1.0 1.0 1.3 2.79 YPR028W 1.0 1.1 4.0 1.7 1.0 1.4 0.8 0.7 0.5 0.8 1.4 0.6 1.7 0.8 0.9 1.3 1.2 1.7 4.06 YPR149W 1.0 1.1 5.9 1.7 1.7 1.6 2.1 0.6 1.2 1.8 1.1 0.7 1.4 1.3 1.0 2.2 1.1 1.1 2.65 YAL016W 0.8 1.0 2.8 0.9 0.9 0.9 1.1 1.0 1.2 1.9 0.9 0.8 1.4 0.9 1.1 1.1 0.8 1.3 1.00 YBR283C 0.6 0.7 1.9 1.2 1.4 2.2 0.8 0.8 1.5 1.2 2.0 0.8 0.8 0.6 1.4 0.9 0.9 0.9 2.62 YBR286W 0.7 1.4 3.8 1.2 1.3 1.5 1.3 0.9 1.2 1.6 1.0 1.1 1.8 1.5 1.3 2.6 0.8 1.6 2.98 YCL008C 0.8 1.1 1.8 1.2 1.2 0.9 0.9 0.7 0.9 1.4 0.9 0.9 1.0 0.9 1.4 0.6 0.9 0.9 0.47 YCR069W 1.0 1.2 2.0 0.9 1.1 1.4 1.1 0.7 0.8 0.7 1.3 1.4 1.6 1.0 2.4 1.2 1.2 1.3 0.97 YDL061C 1.4 0.5 2.9 0.9 1.3 1.1 0.5 1.0 0.0 0.5 1.4 1.0 0.1 0.7 1.0 0.6 1.1 1.0 4.40 YDR151C 1.3 1.0 2.3 1.8 0.8 0.7 0.8 1.5 2.6 2.8 2.1 0.9 2.8 1.1 0.6 1.2 0.8 1.1 0.96 YDR382W 1.3 0.5 2.4 1.2 1.1 0.6 0.4 1.2 0.0 0.4 1.2 0.7 0.1 0.7 1.1 0.4 1.0 1.0 6.40 YDR385W 0.6 0.4 3.5 0.9 1.1 0.5 0.4 0.7 0.2 0.5 0.9 0.9 0.3 0.5 0.8 0.3 0.6 0.4 7.27 YDR407C 0.7 1.0 2.0 0.7 0.8 1.2 1.4 0.9 1.5 1.7 1.2 1.0 1.3 0.8 1.3 1.0 0.9 0.9 0.52 YGL206C 0.4 3.5 2.0 0.5 0.6 0.8 0.8 0.5 0.7 0.7 0.9 0.7 1.1 0.8 1.3 0.6 0.8 1.0 1.04 YGR172C 0.6 1.3 2.5 1.3 0.6 0.9 1.0 0.8 0.4 1.1 0.8 0.8 0.7 1.1 1.9 1.0 1.1 1.1 0.94 YIL015W 1.1 1.7 2.0 2.5 0.9 0.4 0.9 0.9 0.3 1.1 0.8 0.9 0.8 5.9 1.1 0.8 0.8 1.0 0.17 YIL018W 1.0 0.4 2.3 1.4 0.9 0.4 0.8 0.0 0.3 1.2 0.6 0.0 0.6 0.6 0.4 0.8 0.8 6.27 YJL138C 1.0 0.7 2.3 1.4 0.9 0.8 0.8 1.2 0.2 0.7 1.2 0.8 0.3 0.7 0.9 0.6 0.9 1.0 7.38 YJL191W 1.0 0.4 2.2 0.7 1.3 1.0 0.8 0.0 0.4 1.1 1.0 0.9 1.1 0.7 2.2 1.0 1.0 1.86 YJR047C 1.1 0.8 2.6 1.1 1.1 1.1 0.4 0.9 0.7 0.5 1.1 0.9 0.9 0.9 0.6 0.8 0.8 0.9 5.29 YJR119C 0.9 1.0 2.0 1.0 0.9 1.4 1.1 1.6 0.5 1.3 1.1 0.9 1.2 1.3 1.5 1.0 0.7 0.9 0.30 YJR123W 1.2 0.6 2.2 1.0 1.3 1.0 0.4 1.2 0.0 0.5 0.9 0.8 0.1 0.6 1.1 0.4 0.8 0.9 7.84 YJR145C 0.8 0.7 2.3 1.3 0.4 0.4 1.0 0.0 0.4 0.8 0.6 0.0 0.6 0.8 0.5 0.8 0.9 4.82 YLR110C 1.4 0.8 2.7 1.2 1.7 0.9 0.4 0.8 0.3 0.8 3.2 0.7 0.5 0.5 1.7 0.8 0.9 1.1 3.99 YLR264W 1.1 0.4 2.2 1.0 1.1 0.7 0.4 1.0 0.0 0.3 0.8 1.1 0.3 1.2 1.2 0.5 1.0 1.1 3.91 YLR340W 0.8 0.4 2.6 1.0 0.6 0.7 0.3 0.9 0.0 0.5 1.4 0.9 0.1 0.5 1.3 0.2 0.9 0.7 6.55 YLR388W 1.6 0.4 1.9 1.0 2.5 0.7 0.5 1.2 0.2 0.7 1.0 0.6 0.1 0.8 0.6 0.5 0.8 1.0 4.48 YMR092C 0.6 1.2 1.9 1.3 0.8 0.9 1.2 0.9 1.5 1.7 1.2 0.9 1.7 0.8 1.1 1.2 0.9 1.3 1.43 YMR101C 1.1 1.8 1.9 2.9 0.9 0.4 0.9 0.8 −4.0 1.6 −0.3 0.7 0.8 1.1 1.0 0.9 0.7 0.8 0.16 YNL069C 1.2 0.3 2.8 2.3 0.7 0.4 0.3 1.0 0.0 0.4 1.0 0.6 0.1 0.9 1.0 0.3 0.8 0.6 4.03 YNL135C 1.1 0.9 2.0 1.4 1.7 0.9 0.8 0.5 0.7 0.5 0.7 0.8 0.9 0.5 1.0 1.4 1.2 1.7 3.05 YOL039W 1.2 0.3 3.9 0.7 1.3 0.4 0.3 1.0 0.0 0.9 1.1 0.7 0.1 0.5 0.8 0.4 0.7 0.7 4.94 YOL120C 1.0 0.3 2.3 0.8 1.5 0.3 0.4 0.8 0.0 0.3 1.0 0.7 0.1 0.6 0.6 0.3 0.6 0.8 4.42 YOR230W 1.2 2.3 3.0 1.0 0.9 1.1 0.6 0.6 0.6 0.7 1.6 1.4 1.5 0.7 0.6 1.6 1.2 1.6 1.76 YOR298W 0.9 0.9 3.2 0.5 1.5 0.9 0.6 0.7 0.6 1.0 0.1 0.7 1.1 2.1 1.2 0.5 1.0 0.8 0.41 YPL048W 0.7 0.7 2.6 1.2 0.7 0.6 0.6 0.8 1.6 0.6 1.7 1.0 0.9 0.6 1.5 1.3 1.2 1.0 2.11 YPL179W 1.0 1.5 2.4 1.0 1.1 1.6 1.2 0.8 1.2 1.1 1.1 1.0 1.3 0.8 1.2 1.4 1.3 1.3 1.38 YPL218W 1.5 0.9 2.5 1.7 1.1 1.5 1.3 1.4 1.1 1.2 1.1 1.2 1.0 1.5 1.1 1.7 1.1 1.8 2.98 YPL220W 1.3 0.9 2.3 1.4 1.1 1.3 0.6 1.2 0.0 0.5 1.3 0.5 0.1 0.6 0.6 0.5 1.1 1.1 8.33 YPR080W 1.3 1.3 2.8 1.2 1.4 1.4 0.9 1.3 0.7 1.1 1.0 1.0 1.3 0.6 1.5 0.6 1.1 1.0 8.03 YPR181C 0.5 0.8 2.3 0.6 1.0 2.0 1.3 0.5 1.0 0.7 1.3 1.0 1.7 2.4 1.5 1.6 1.8 1.6 1.84 YBR290W 1.3 1.4 0.8 3.0 1.0 1.1 1.4 1.5 2.0 1.8 1.2 1.0 1.7 1.4 0.9 1.3 1.2 2.1 1.34 YCR091W 1.3 1.1 0.6 2.2 1.3 1.3 1.3 1.1 0.8 1.2 0.8 1.1 1.3 1.3 0.7 2.7 1.3 1.4 0.22 YFL026W 1.0 0.8 1.2 5.0 1.4 1.0 1.2 1.3 0.6 1.5 1.3 0.8 1.1 1.1 1.0 1.0 1.0 1.0 0.27 YOR003W 0.9 1.1 1.3 3.3 1.6 1.1 1.1 0.9 1.6 1.3 0.7 0.8 1.0 1.2 2.8 1.3 1.0 1.1 0.30 YCR038C 0.9 1.1 0.9 2.5 0.9 0.9 0.9 0.9 0.7 0.7 1.1 0.8 1.0 1.1 0.7 1.0 0.9 1.1 0.31 YDL119C 1.0 0.8 0.6 2.2 0.9 0.6 1.3 1.1 1.3 1.1 1.5 0.9 1.1 1.2 0.5 1.2 1.0 1.0 0.77 YDL220C 0.9 1.3 1.1 1.6 1.2 1.8 1.1 0.8 0.2 1.3 0.8 1.0 1.6 0.9 1.6 0.8 1.1 0.9 0.24 YDR125C 1.1 0.9 1.0 1.7 1.1 0.8 1.0 1.2 0.7 1.9 1.0 0.8 0.9 1.0 0.8 1.7 0.9 1.2 0.35 YDR225W 1.0 0.6 0.6 1.6 1.9 0.5 0.4 0.8 0.3 0.7 2.7 0.4 0.2 0.8 0.1 0.8 1.1 1.8 5.54 YER066W 0.9 0.7 0.9 2.1 1.5 1.3 1.3 0.7 1.7 1.4 1.5 0.7 0.9 1.1 0.5 3.3 1.1 1.1 0.66 YER076C 0.8 0.9 1.2 1.9 1.1 0.6 0.8 0.7 0.2 1.2 0.7 0.7 1.1 0.9 0.8 1.3 1.0 1.0 0.33 YFR006W 0.9 1.8 1.1 3.4 0.7 0.8 1.4 1.0 −1.6 0.7 1.2 1.0 0.9 0.9 0.8 1.2 0.9 1.3 1.54 YGL208W 0.9 1.8 1.1 2.2 0.7 0.6 1.1 0.7 1.4 1.3 1.3 0.8 1.5 0.9 1.8 3.1 0.8 1.3 0.32 YGR023W 1.0 0.9 1.1 4.2 1.0 1.2 1.0 1.2 1.2 3.2 2.4 0.9 1.4 1.3 1.1 0.9 1.2 1.5 0.69 YGR108W 0.9 3.9 0.3 3.6 0.8 0.1 0.3 0.5 0.0 0.1 0.5 0.4 0.3 0.8 0.2 0.4 0.7 1.0 0.93 YHR195W 1.1 1.5 0.6 2.4 1.5 1.0 1.3 1.6 1.8 0.8 1.4 0.9 1.2 1.2 0.7 3.7 1.0 1.5 1.12 YIL050W 1.0 1.3 1.3 2.4 0.9 0.7 1.1 1.2 1.3 1.9 0.9 1.0 1.0 1.3 0.6 2.7 1.0 1.1 0.52 YJR050W 1.0 0.6 0.7 2.1 1.2 1.4 1.1 1.8 2.0 1.3 0.8 0.8 1.9 1.3 0.9 1.5 0.9 1.1 0.85 YKL093W 1.0 1.6 1.4 3.6 0.8 0.8 0.7 0.9 1.5 1.6 0.9 0.9 1.2 1.1 0.8 2.9 0.8 1.0 0.38 YMR053C 1.1 1.0 0.8 2.1 0.9 1.3 0.9 1.0 2.2 1.4 1.3 0.9 1.5 1.3 2.4 2.3 1.1 1.6 0.31 YNL139C 0.8 1.1 0.8 2.0 1.9 1.0 1.0 0.9 0.6 0.7 0.8 0.5 1.2 0.7 1.4 1.1 1.1 1.0 0.47 YOR122C 1.0 0.7 1.8 1.9 1.7 1.3 1.2 1.0 1.1 0.9 1.5 0.8 1.0 1.2 1.6 1.5 1.0 2.2 3.06 YOR312C 1.2 0.4 1.0 1.9 0.7 0.6 0.6 1.2 0.0 0.3 0.8 0.7 0.1 0.7 0.7 0.5 1.2 1.0 5.24 YOR327C 2.3 1.8 0.5 1.9 1.0 1.4 1.4 1.9 1.4 2.2 2.1 1.0 2.1 1.5 0.9 1.5 2.2 2.1 1.46 YPL001W 0.9 0.9 1.0 2.5 1.7 0.7 1.0 1.2 0.7 1.0 1.3 0.7 0.8 1.3 1.3 0.8 0.9 1.2 0.74 YPL230W 1.2 1.7 1.8 4.0 0.8 1.0 1.1 1.0 0.9 2.7 3.1 1.0 2.0 1.3 0.7 2.0 1.0 1.6 0.47 YER025W 0.6 0.7 0.6 0.6 1.5 1.0 1.5 1.1 0.4 0.6 1.2 0.7 0.6 2.1 0.8 2.6 1.8 2.3 1.96 YHR185C 0.9 1.1 1.4 0.7 1.4 1.0 1.3 0.8 −0.6 0.9 0.7 0.8 0.4 1.7 1.3 3.2 1.4 3.0 1.64 YIL076W 1.3 0.6 1.1 1.0 1.8 0.6 0.5 1.3 1.0 1.4 1.1 0.8 0.8 1.4 1.0 0.8 1.2 2.5 3.73 YMR238W 1.9 1.3 1.1 1.3 1.5 1.3 1.2 0.9 1.3 1.4 1.2 1.0 1.5 1.2 2.3 1.4 2.2 2.4 1.36 YBR009C 1.6 0.8 0.4 1.7 1.4 1.0 0.5 1.2 0.6 0.6 0.8 0.5 0.4 1.1 0.2 0.4 1.0 2.4 7.00 YBR010W 1.0 0.8 0.5 2.0 0.8 1.1 0.8 1.3 0.5 0.7 1.0 0.7 0.4 1.0 0.3 0.8 1.1 2.3 7.25 YCL067C 1.2 1.1 0.3 1.7 1.1 1.7 1.3 1.7 1.4 1.9 1.6 1.0 1.4 2.1 2.2 1.7 0.8 2.2 3.15 YCR096C 1.1 0.9 0.4 1.6 2.1 1.2 1.7 1.5 1.2 1.6 1.4 1.0 1.0 2.1 2.1 1.8 1.0 2.1 2.34 YDL137W 1.4 1.1 1.2 1.2 1.8 1.0 2.0 1.1 1.1 1.3 1.5 1.6 1.7 1.4 1.3 2.3 1.3 2.2 4.95 YDL192W 1.4 1.0 0.6 1.2 1.4 1.0 1.7 1.5 0.8 0.6 1.3 1.1 0.9 1.2 1.3 1.3 1.1 2.3 5.57 YDR224C 1.1 0.7 0.8 0.9 1.2 1.0 0.8 1.4 1.1 1.3 1.1 0.7 0.5 1.7 0.3 1.1 1.2 2.2 5.62 YDR378C 1.3 1.3 1.4 1.3 1.0 1.0 1.4 1.5 0.5 1.3 0.8 0.9 0.8 1.4 0.8 1.0 1.7 2.2 2.40 YMR197C 1.3 1.6 1.4 1.9 1.1 1.6 1.5 1.4 1.9 2.5 1.0 1.1 1.5 4.1 1.7 1.9 1.2 2.2 1.20 YOL109W 2.0 2.0 1.5 1.8 1.0 1.3 1.2 1.5 0.1 1.1 1.0 0.8 0.5 1.4 1.0 0.8 1.6 2.2 4.13 YPL010W 1.0 1.1 0.9 1.0 1.4 1.0 1.9 1.5 1.7 1.5 1.3 1.1 1.1 1.3 1.2 1.3 1.3 2.0 3.25 YHR132C 0.8 0.7 1.7 1.4 1.0 0.7 0.8 0.8 0.9 1.1 1.1 0.8 1.2 0.9 1.4 2.3 0.8 1.3 1.52 YJL141C 1.0 0.8 1.0 1.6 1.5 1.1 1.1 0.9 1.2 1.3 1.2 0.8 1.4 0.8 0.8 2.2 1.4 1.6 0.94 YKR098C 1.0 1.1 1.2 1.7 1.1 1.8 1.7 1.3 1.4 2.7 1.9 1.1 1.4 1.4 0.9 3.9 1.1 1.6 0.55 YLR206W 0.7 1.6 1.4 1.1 1.1 0.5 0.7 0.8 1.5 1.0 1.3 0.8 1.4 0.8 2.4 2.3 1.1 1.2 0.72 YAL055W 1.2 1.0 0.9 1.0 1.4 1.3 1.5 1.9 1.0 1.4 1.3 1.2 1.5 1.6 1.1 2.6 1.3 1.3 0.62 YAR062W 1.2 1.8 1.4 0.7 1.0 0.6 1.3 0.9 0.4 0.9 −1.1 0.8 1.2 1.1 1.3 2.4 0.9 1.0 0.32 YBL102W 0.8 1.0 1.4 1.2 0.9 2.5 1.6 0.8 2.3 1.1 1.2 0.9 1.7 1.1 1.1 2.0 2.4 1.5 1.26 YBR161W 1.2 0.8 2.3 0.7 1.1 3.0 0.9 0.4 0.4 1.1 0.6 1.0 0.9 1.5 2.1 1.5 2.2 0.72 YCR039C 1.9 2.1 0.3 0.9 1.9 1.5 1.4 1.6 1.8 2.2 1.2 0.8 1.0 1.7 1.9 2.1 1.0 2.1 1.73 YDL018C 1.3 0.9 0.9 1.1 1.8 1.4 1.2 1.3 1.0 1.0 0.9 0.7 1.0 1.5 1.1 3.1 1.5 1.7 0.84 YDR022C 1.1 1.2 0.8 0.9 1.5 2.2 1.8 1.4 0.9 1.4 0.9 0.7 1.3 2.1 1.0 2.1 1.3 1.2 0.47 YDR181C 1.1 1.2 0.8 1.4 0.9 0.7 1.0 1.2 2.0 0.9 0.8 0.7 0.7 1.3 1.2 2.0 0.8 1.2 0.48 YGR036C 0.9 0.8 0.9 1.1 1.3 1.3 1.0 0.8 0.9 0.9 0.9 1.0 1.3 1.0 0.7 2.0 1.3 1.1 1.12 YGR120C 1.2 1.8 0.5 1.0 1.8 1.5 1.6 1.3 0.3 1.2 1.1 0.7 0.5 1.0 1.2 1.9 1.1 1.2 0.36 YGR131W 0.8 2.1 1.9 1.1 0.9 1.9 1.1 1.1 1.9 5.8 1.1 0.5 1.4 2.0 0.8 2.6 1.3 1.0 0.41 YGR167W 1.1 1.1 0.6 1.5 0.9 1.7 1.4 1.4 1.4 1.9 1.1 1.1 1.6 1.7 1.6 2.8 1.3 1.7 1.79 YHL024W 1.2 0.8 1.6 1.1 1.5 1.2 1.3 0.8 2.1 3.6 1.1 1.6 1.6 2.1 2.9 3.8 1.4 1.4 0.58 YJL113W 1.2 1.9 1.2 1.2 0.7 1.2 1.3 1.3 2.1 1.2 0.7 0.9 1.3 1.7 2.1 0.9 1.5 0.41 YJL146W 1.3 1.9 1.2 2.0 0.8 0.7 1.3 1.0 1.0 1.7 −1.1 1.1 0.8 1.5 1.2 1.8 1.0 1.3 0.30 YJR019C 0.8 1.8 1.9 1.6 1.1 0.8 0.9 0.7 1.1 0.6 2.4 1.1 1.4 0.8 1.1 2.6 1.8 1.4 0.33 YJR049C 1.0 1.2 1.0 1.0 0.7 0.6 1.0 1.2 1.4 1.4 1.6 1.0 2.1 1.2 1.2 1.7 0.9 1.2 0.44 YLR078C 0.9 1.1 0.7 1.4 0.8 1.2 1.1 0.8 1.1 2.9 1.0 0.8 1.2 0.6 2.2 1.2 1.2 1.02 YNR037C 0.9 0.9 0.9 1.7 1.2 0.7 1.7 1.1 1.3 1.7 1.5 0.7 2.0 1.2 0.8 1.9 1.4 1.6 1.34 YOR028C 1.4 0.7 1.1 2.3 1.6 1.0 1.2 1.5 1.2 2.0 1.5 0.6 0.8 1.3 1.1 3.7 0.8 1.7 0.78

The tables show that the expressed mRNA of about 700 of 2400 unknown yeast genes was induced by any one of toxic chemical substances such as heavy metals, agricultural chemicals, surfactants (Table 1), as well as the expressed mRNA of 167 mitochondria-located genes (Table 2), 52 DNA repair genes (Table 3), 161 energy genes (Table 4), 142 transport facilitation genes (Table 5), 90 stress protein genes (Table 6), 142 metabolism genes (Table 7), 60 detoxification genes (Table 8), and 507 genes belonging to other category (Table 9). Here, when the value of the following is 2 or more, then it is considered significant:

The level of expressed mRNA in the presence of chemical substance

The level of expressed mRNA in the absence of chemical substance.

“Intensity” indicated in the rightmost column of Tables 1 to 9 is a value of the level of expressed mRNA of each gene in control cells as divided by the average level of the expressions of the whole genes. When the intensity is low, the error of measurement may be possibly large. The detection is considered more precise when expression magnification (expressed mRNA in the presence of chemical substance/expressed mRNA in the absence of chemical substance) is larger. Yeast gene as used in the processes according to the invention is selected, of which the intensity is preferably 0.3 or more, more preferably 0.5 or more, and of which the expression magnification is preferably 3 or more, more preferably 5 or more. 

1-16. (canceled)
 17. A process for detecting 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile in a test material, which comprises contacting the test sample with a cell comprising a combination of a plurality of yeast genes: YCR107W, YFL056C, YLL057C, YHR139C, YMR004W, YPR167C, YDL218W, YDL243C, YBL075C, YLL056C, YNL277W, YBR008C, YPL280W, YOL165C, YJR155W, YGR142W, YJR010W, YBR241C, YKL107W, YGR154C, YFL030W, YFR030W, YFL055W, YMR322C, YBL065W, YER103W, YBR256C, YGR197C, YLL062C, YDR253C, YJL163C, YLR216C, YNL117W, YLR092W, YBR213W, YPL196W, YHR112C, and YDR374C, and detecting an increase in mRNA.
 18. The process according to claim 17, which comprises: (1) adding a test material to the cell, and incubating them; (2) extracting mRNA from the cell; (3) preparing cDNA from the mRNA via reverse transcription using labeled nucleotides; and (4) hybridizing the cDNA as used as probe with the gene as defined in claim
 17. 19. The process according to claim 17, wherein the mRNA is detected by northern blotting.
 20. The process according to claim 19, which comprises: (1) adding a test material to the cell, and incubating the mixture; (2) extracting mRNA from the cell; and (3) hybridizing the mRNA with the genes as defined in claim
 17. 21. The process according to claim 20, wherein a step (3) is conducted on a microarray containing a combination of genes as defined in claim
 17. 